Caveolae and cancer: A new mechanical perspective

Lamaze, Christophe; Torrino, Stéphanie

doi:10.4103/2319-4170.164229

Cited by 42 publications

(38 citation statements)

References 136 publications

(178 reference statements)

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“…Along with being a component of caveolae, Cav-1 is involved in several cellular processes that include cell cycle regulation, cholesterol trafficking and efflux, senescence, signal transduction, angiogenesis, endocytosis, transcytosis, and apoptosis (Table 1) [95,127,128,129,130,131,132]. Multiple lines of evidence indicate that Cav-1 interacts with a variety of signal molecules such as Src tyrosine kinases, glycosylphosphatidylinositol linked receptors, small guanosine triphosphate hydrolyzing enzymes (GTPases, heteromeric G protein, ion channels, endothelial nitric oxide synthase (eNOS), protein kinase A, and mitogen-activated protein kinases [132,133,134]. Cav-1, therefore, acts as a scaffolding molecule and can directly associate and modulate several signal transducing molecules.…”

Section: Caveolin 1 and Its Functionmentioning

confidence: 99%

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The Role of Caveolin 1 in HIV Infection and Pathogenesis

Mergia

2017

Viruses

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Caveolin 1 (Cav-1) is a major component of the caveolae structure and is expressed in a variety of cell types including macrophages, which are susceptible to human immunodeficiency virus (HIV) infection. Caveolae structures are present in abundance in mechanically stressed cells such as endothelial cells and adipocytes. HIV infection induces dysfunction of these cells and promotes pathogenesis. Cav-1 and the caveolae structure are believed to be involved in multiple cellular processes that include signal transduction, lipid regulation, endocytosis, transcytosis, and mechanoprotection. Such a broad biological role of Cav-1/caveolae is bound to have functional cross relationships with several molecular pathways including HIV replication and viral-induced pathogenesis. The current review covers the relationship of Cav-1 and HIV in respect to viral replication, persistence, and the potential role in pathogenesis.

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Section: Caveolin 1 and Its Functionmentioning

confidence: 99%

“…* These functions are reviewed in detail in [94,95,104,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,127,128,129,130,131,132]. …”

Section: Figurementioning

confidence: 99%

The Role of Caveolin 1 in HIV Infection and Pathogenesis

Mergia

2017

Viruses

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“…The persistent suppression of cav-1 promotes the emergence of pathogenic phenotypes, and several studies associate it with advanced stages of breast cancer and prostate cancer metastasis, and a poor prognosis (13) .…”

Section: Caveolinmentioning

confidence: 99%

“…The CAV-1 gene that encodes cav-1 protein is a negative regulator and tumor suppressor gene of the Ras-p42/44 MPak cascade (12) . This protein is responsible for integrin binding with tyrosine kinase prior to the start of the Ras-MAPK pathway to promote cell cycle progression (13) .…”

Section: Caveolinmentioning

confidence: 99%

CAVEOLINA-1 implicaciones fisiológicas y patológicas

Pereira-Prado

Tapia

Bologna‐Molina

2017

Odontoestomatología

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Caveolae are plasma membrane invaginations formed by proteins called caveolins. Of the three caveolin isoforms, the most studied one through years has been caveolin-1 (cav-1), which has an important role in cell signaling, and its gene, CAV-1, is part of the family of tumor suppressor genes. As its role depends on the context, the participation and function of cav-1 in tumors is complex and remains controversial. Cav-1 interacts with a series of receptors and molecules that regulate the initial steps of cellular transformation to malignity. It also participates in the cell cycle, angiogenesis, extracellular matrix remodeling, cell proliferation, among other processes. The study of this molecule is important due to its function as a biomarker associated to the diagnosis, prognosis and therapeutic target in pathological processes.

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“…[1] Cav1 is a key component of small plasma membrane invaginations named caveolae, which can flatten out under mechanical stress to buffer an increase in membrane tension. For years, Cav1 has been described as either a pro-or an anti-tumorigenic agent depending on the stage of tumor development.…”

mentioning

confidence: 99%