Caveolin-1 and Tight Junction Expression in Human Intestine as a Susceptibility Marker of Necrotizing Enterocolitis

Leiva, Tyler D; Chen, Xue; Liebe, Heather; Golubkova, Alena; Schlegel, Camille; Hunter, Catherine J.

doi:10.1097/01.xcs.0000894324.93579.20

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“…Additionally, claudins are transmembrane proteins that also function as tight junctions. Claudin-2 is known to be a pore-forming protein that allows for the passage of extracellular contents in paracellular transport in the intestinal barrier [71][72][73][74]. Ares et al found that claudin-2 is overexpressed in the setting of inflammatory stressors and that there is increased binding with Cav1 [71].…”

Section: Caveolin-1 and The Intestinal Barriermentioning

confidence: 99%

“…Claudin-2 is known to be a pore-forming protein that allows for the passage of extracellular contents in paracellular transport in the intestinal barrier [71][72][73][74]. Ares et al found that claudin-2 is overexpressed in the setting of inflammatory stressors and that there is increased binding with Cav1 [71]. The relationship between Cav1 and claudin-2 as well as occludin is evident.…”

Section: Caveolin-1 and The Intestinal Barriermentioning

confidence: 99%

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Caveolin-1: A Review of Intracellular Functions, Tissue-Specific Roles, and Epithelial Tight Junction Regulation

Dalton,

Schlegel,

Hunter

2023

Biology

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Caveolin-1 (Cav1) is a vital protein for many cellular processes and is involved in both the positive and negative regulation of these processes. Cav1 exists in multiple cellular compartments depending on its role. Of particular interest is its contribution to the formation of plasma membrane invaginations called caveolae and its involvement in cytoskeletal interactions, endocytosis, and cholesterol trafficking. Cav1 participates in stem cell differentiation as well as proliferation and cell death pathways, which is implicated in tumor growth and metastasis. Additionally, Cav1 has tissue-specific functions that are adapted to the requirements of the cells within those tissues. Its role has been described in adipose, lung, pancreatic, and vascular tissue and in epithelial barrier maintenance. In both the intestinal and the blood brain barriers, Cav1 has significant interactions with junctional complexes that manage barrier integrity. Tight junctions have a close relationship with Cav1 and this relationship affects both their level of expression and their location within the cell. The ubiquitous nature of Cav1 both within the cell and within specific tissues is what makes the protein important for ongoing research as it can assist in further understanding pathophysiologic processes and can potentially be a target for therapies.

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