Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis

Sun, Guoyang; Wu, Jia‐Zhu; Wu, Jiansheng; Pan, Yuting; Jin, Rong

doi:10.1007/s11670-012-0023-0

Cited by 29 publications

(26 citation statements)

References 22 publications

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“…Though Cav-1 over-expression was documented to associate with Lymph node metastasis and TNM stage (Sun et al, 2012;Nam et al, 2013), here our results suggested that Cav-1 positive expression was not correlated with these clinicopathological features.…”

Section: Discussioncontrasting

confidence: 79%

“…Indeed, even if it may play a role of tumor suppressor by inhibiting the signalling transduction products of some proto-oncogenes (Razani et al, 2001), its tyrosine-14 phosphorylation leads to growth stimulation (Lee et al, 2000), demonstrating that Cav-1 may also make an effect as a pro-tumorigenic factor. In the prognosis of gastric cancer, it has been reported that Cav-1 expression may serve as a promising molecular biomarker recently (Gao et al, 2005;Barresi et al, 2008;He et al, 2012;Sun et al, 2012;Nam et al, 2013;Zhao et al, 2013). However, these results were controversial.…”

Section: Discussionmentioning

confidence: 99%

“…1 record was eliminated data of the repeated data from the same population. Thus, a total of 6 papers met the inclusion criteria for the present meta-analysis (Gao et al, 2005;Barresi et al, 2008;He et al, 2012;Sun et al, 2012;Nam et al, 2013;Zhao et al, 2013) (Figure 1). We …”

Section: Description Of Studiesmentioning

confidence: 99%

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Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

Yang

Miao²,

Lu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The relationship between caveolin-1 (Cav-1) and clinicopathological characteristics of gastric cancer is controversial, although Cav-1 plays an important role in tumor metastasis. To evaluate the clinicopathological and prognostic value of expression in patients with gastric cancer, a meta-analysis was performed to investigate the impact on clinicopathological parameters and prognosis in gastric cancer cases. Studies assessing these parameters for Cav-1 in gastric cancer were identified up to June 2014. Finally, a total of six studies met the inclusion criteria. Our combined results showed that Cav-1 expression was significantly associated with the Lauren classification (pooled OR=0.603, 95% CI: 0.381-0.953, P=0.030). Furthermore, we found that Cav-1 expression predicted a better overall survival in gastric cancer patients (pooled OR=0.590, 95% CI: 0.360-0.970, P=0.038, fixed-effect). In conclusion, the overall data of the present meta analysis showed that Cav-1 expression was not correlated with clinicopathological features except for the Lauren classification. Simultaneously, Cav-1 overexpression predicted a better overall survival in gastric cancer. Cav-1 expression in tumors is a candidate positive prognostic biomarker for gastric cancer patients.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

Yang

Miao²,

Lu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The way we constructed the TMAs and the microarray system instrument were the same with our previous study [24], [25]. As previously studies did not report intratumoral heterogeneity of Cav-1 expression in GC and our feasibility experiment indicated that one core per tumor on TMA and large sections showed a good consistency [26], [27], [28], therefore, in testing experiment, one core was sampled in each case. Briefly, one core with a diameter of 1.5 mm was taken from each sample and inserted into empty “recipient” paraffin blocks; these blocks were cut into sections (4 µm thick) and used for QDs-IHC analysis.…”

Section: Methodsmentioning

confidence: 93%

Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer

Zhao

Gao³

et al. 2013

PLoS ONE

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AimsAltered expression of epithelial or stromal caveolin-1 (Cav-1) is observed in various types of human cancers. However, the clinical significance of Cav-1 expression in gastric cancer (GC) remains largely unknown. The present study aims to explore the clinicopathological significance and prognostic value of both tumor cells and cancer associated fibroblasts (CAFs) Cav-1 in GC.Methods and ResultsQuantum dots immunofluorescence histochemistry was performed to examine the expression of Cav-1 in 20 cases of gastritis without intestinal metaplasia (IM), 20 cases of gastritis with IM and 286 cases of GC. Positive rates of epithelial Cav-1 in gastritis without IM, gastritis with IM and GC showed a decreasing trend (P = 0.012). Low expression of Cav-1 in CAFs but not in tumor cells was an independent predictor of poor prognosis in GC patients (P = 0.034 and 0.005 respectively in disease free survival and overall survival). Cav-1 level in tumor cells and CAFs showed no significant correlation with classic clinicopathological features.ConclusionsLoss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient, suggesting CAFs Cav-1 may be a candidate therapeutic target and a useful prognostic marker of GC.

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“…In a study by Sun et al [26], Cav-1 expression was evaluated in 5 gastric cancer tissues, 40 precancerous gastric tissues (19 intestinal metaplasia and 21 dysplasia), and 42 nonatrophic gastritis tissues. They showed that Cav-1 positivity was significantly lower in the gastric cancer tissues compared to precancerous gastric and non-atrophic gastritis tissues [26]. Moreover, different from our study, low Cav-1 expression was found to be significantly correlated with lymph node metastasis and advanced pTNM stage.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

et al. 2017

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Background: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment.

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Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis

Cited by 29 publications

References 22 publications

Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer

Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

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