Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer

Abstract

Caveolin-1 is the principal components of caveolae membranes, implicated in oncogenesis and angiogenesis. Until now, its expression and functional significance in hepatocellular carcinoma (HCC) are still unclear. In the present study, we demonstrated that expression of caveolin-1 was markedly upregulated in HCC patients. In addition, increased caveolin-1 expression correlated positively with the histological differentiation, portal venous invasion, hepatic venous invasion, intrahepatic metastases, and recurrence, suggesting a role for caveolin-1 in the progression of HCC. HepG2 cell line was transfected with pcDNA3.1/caveolin-1 to observe the significance of the change in caveolin-1 expression. We showed that caveolin-1 overexpression could not only protect HepG2 cells from apoptosis but also enhance its migration and invasion by upregulating MMP-2, MMP-9, and VEGF expressions. Collectively, our clinical and in vitro data indicate that the status of caveolin-1 expression may be one of causative factors for the invasion and poor prognosis in HCC.

Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil

“…It has been reported that elevated expression of Cav-1 is associated with the development of resistance in hepatocellular cancer cells to paclitaxel (27). Additionally, Cav-1 participates in cell survival, tumor progression, metastasis and poor prognosis (19)(20)(21)(22). Cav-1 has been found to be correlated with colon cancer growth, metastasis and tumorigenicity (34,35).…”

“…Cav-1, as the principal component of caveolae, plays an important role in material transportation, endothelial infiltration and tumorigenesis (18). Cav-1 acts as a scaffolding protein by interacting with signaling molecules through a caveolin scaffolding domain to modulate gene expression, signal transduction and protein translocation in the cell membrane (18 invasion and metastasis (19)(20)(21)(22). Additionally, it has been shown that Cav-1 is closely associated with the development of drug resistance (23)(24)(25).…”

Downregulation of Tumor Growth and Invasion by Redox-Active Nanoparticles

“…Caveolin-1 (Cav-1) has received the most attention, since its expression has been linked to cancer progression and aggressiveness (58). Cav-1 plays a role not only in cell death and survival, but also in cell migration (38) and invasion (61).…”

Prognostic value of metastatic tumoral caveolin-1 expression in patients with resected gastric cancer.

“…Similarly, Cav-1 protein was dysregulated in several other gastrointestinal cancers. Tumoral Cav-1 expression increased in cancers cells compared to their normal counterparts, whereas stromal Cav-1 expression decreased in cancer tissues compared to adjacent normal tissues, such as pancreatic cancer [9,19], esophageal cancer [20], and hepatocellular carcinomas [21]. Cav-1 expression is known to be regulated mainly by inactivation of oncogenes or inactivation of tumor suppressive genes, TGF-β, and oxidative stress in the tumor microenvironment [22,23].…”