Abstract:Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. Here, we report that chemo-resistant gastric cancer cells heavily rely on endocytosis, facilitated by caveolin-1, for survival. caveolin-1 was highly up-regulated in the most malignant SEM (stem-like, EMT, and mesenchymal)-type gastric cancer cells, allowing caveolin-1-mediat… Show more
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