Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients.

Requeña, Ignacio; Arias, M; López-Ibor, L.; Pereiró, I; Barba, Anne; Alonso, Antonio López; Montón, E

doi:10.1136/jnnp.54.7.590

Cited by 136 publications

(68 citation statements)

References 31 publications

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“…Seizures seem to happen precociously when CMs are located in the frontal or temporal lobes 25 , and apparently their risk of development varies from 1.5 to 4.8% per year 4,21 . Focal deficits and intracranial hypertension may be caused not only by acute macro-hemorrhage, but also due to progressive growing secondary to recurrent micro-hemorrhage 24 .…”

Section: Managementmentioning

confidence: 99%

Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases

Amato¹,

Madureira²,

Oliveira³

2013

Arq. Neuro-Psiquiatr.

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Objectives: To determine the clinical presentation and treatment outcome of pediatric intracranial cavernous malformation (CM) in a single-centered institution. Methods: Clinical data review of 30 patients under 18 years-old who had undergone surgery for cavernous malformation from January 1993 to December 2011. Results: The Study Group included 18 males and 12 females (mean age: 8.7 years-old). Symptoms at presentation were seizures (16/30, 53.3%), headache (15/30, 50.0%), and focal neurological deficits (11/30, 36.6%). Multiple cavernous malformations were found in 5/30 (16.6%). According to location, patients were classified in groups: (G1) brain-steam in 5/30 (16.6%), (G2) cerebellum in 2/30 (6.6%), (G3) supratentorial associated with seizures in 16/30 (53.3%), and (G4) supratentorial without seizures in 7/30 (23.3%). Surgical resection was performed in 26 out of 30 (86.6%) patients. The mean follow-up period was 4.1 years. Of 15 children followed-up with preoperative seizures, all were rendered seizure-free after surgery. Conclusions: For symptomatic solitary cavernous malformation, the treatment of choice is complete microsurgical excision preceded by careful anatomical and functional evaluation. For multiple cavernous malformation or asymptomatic patients, the treatment modalities must be cautiously considered.

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Section: Managementmentioning

confidence: 99%

Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases

Amato¹,

Madureira²,

Oliveira³

2013

Arq. Neuro-Psiquiatr.

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“…Cefaléia e crise convulsiva são manifestações clíni-cas bastante freqüentes em fenômenos vasculares [5][6] .…”

Section: Discussionunclassified

Distonia segmentar como manifestação de angioma cavernoso: relato de caso

Azevedo

Souza

Leite

et al. 2001

Arq. Neuro-Psiquiatr.

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Rodrigues 4RESUMO -A distonia é uma síndrome neurológica cuja etiologia costuma não ser bem definida. Relatamos caso de uma paciente que apresentou aos 16 anos de idade dificuldade para tocar piano, havendo um comprometimento progressivo da mão, antebraço e braço esquerdo que posteriormente evoluiu com crises de ausência e cefaléia. Realizou exames de imagem que evidenciaram angioma cavernoso na região temporal profunda direita (ínsula). É rara a associação entre essas duas enfermidades, não havendo na literatura relato de distonia segmentar associada a crises de pseudoausência e cefaléia com características migranosas secundária ao angioma cavernoso. Vinte e cinco por cento das distonias são secundárias, o que nos faz sugerir uma investigação mínima em neuroimagem.PALAVRAS-CHAVE: distonia segmentar, angioma cavernoso, mal formação arteriovenosa.Segmental dystonia as manifestation of cavernous angioma: case report ABSTRACT -Dystonia is a neurologic syndrome whose ethiology is not well recognized. We report a sixteen year old patient with difficulty in playing piano, with disability of the left hand, forearm and arm. Short after, she underwent absence crises and headache. Neuroradiological exams showed a deep temporal lobe cavernous angioma. It is a rare association between both diseases and there are no reports about segmental dystonia associated to pseudoabsence epilepsy and sporadic migrane secondary to cavernous angioma. Twenty five per cent of dystonias have a secondary cause and we suggest a neuroradiologic investigation. A distonia é uma síndrome neurológica caracterizada por contrações involuntárias, sustentadas, padronizadas e em sua maioria, repetitivas, com antagonismo muscular causando torção, movimentos esporádicos ou posturas anormais. Pode ser classificada de acordo com a intensidade, características clínicas, distribuição, idade de início e etiologia. Quanto à classificação por distribuição, existem as distonias focal, segmentar, multifocal, generalizada e hemidistonia. Em setenta e cinco por cento dos casos não possui um substrato anatomopatológico e etiológico bem definidos. Por conta disso, é considerada muitas vezes como manifestação primária do sistema nervoso central. Inúmeras causas têm sido atribuídas às distonias, entre elas: lesão perinatal, lesões cerebrais focais (tumor, vascular, infecciosa), processos neurodegenerativos, distúrbios metabóli-cos, drogas e outros agentes químicos 1-2 . Considerando-se as causas vasculares, existem poucos trabalhos sobre a mal-formação arteriovenosa e os distúrbios do movimento. Não há relato na literatura da associação entre distonia segmentar e angioma cavernoso como aqui descrevemos. CASOPaciente feminina, 27 anos, negra, natural do Estado do Rio de Janeiro, professora. Trata-se de paciente destra que referia dificuldade para tocar partituras de piano. O quadro foi de instalação progressiva, iniciado aos 16 anos de idade, tendo acometido a mão e posteriormente antebraço e braço esquerdo. Aos 24 anos iniciou crises de ausência além de episódios de cef...

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“…10,22 Although they are most commonly congenital, they may also develop de novo. 21,26 The most common presenting feature, seizures, is thought to be caused by the presence of hemosiderin product from remote hemorrhagic events.…”

Section: Discussionmentioning

confidence: 99%

Association between trauma and acute hemorrhage of cavernous malformations in children: report of 3 cases

Fanous

Jowdy

Lipinski

et al. 2016

PED

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OBJECTIVE Cavernous hemangiomas are benign congenital vascular abnormalities. Intracerebral cavernous hemangiomas have an appreciable risk of spontaneous hemorrhage. Little is known as to whether head trauma increases the risk of bleeding for these lesions. In this study, the authors present a case series of 3 patients with posttraumatic nonspontaneous hemorrhage of intracerebral cavernous malformations (CMs). For the first time, to the authors' knowledge, they propose that trauma might constitute a risk factor for acute hemorrhage in intracerebral cavernomas. METHODS The authors reviewed the charts of all patients with a new diagnosis of intracerebral cavernoma at their pediatric hospital between 2010 and 2014. Patients with a history of head trauma prior to presentation were subsequently studied to identify features common to these posttraumatic, hemorrhage-prone lesions. RESULTS A history of head trauma was identified in 3 of 19 cases. These 3 patients presented with seizures and/or headaches and were found to have acute hemorrhage within a cavernous hemangioma. None of these patients had any history of abnormal neurological symptoms. All 3 abnormal vascular lesions had associated developmental venous anomalies (DVAs). The 3 patients underwent resection of their respective vascular abnormalities, and the diagnosis of cavernous hemangioma was confirmed with postsurgical tissue pathology. All 3 patients had complete resolution of symptoms following complete excision of their lesions. CONCLUSIONS Trauma may represent a risk factor for acute hemorrhage in patients with CMs. The presence of associated DVAs may represent a risk factor for posttraumatic hemorrhage of cavernomas. Excision should be considered in such cases, if feasible.

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Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients.

Cited by 136 publications

References 31 publications

Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases

Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases

Distonia segmentar como manifestação de angioma cavernoso: relato de caso

Association between trauma and acute hemorrhage of cavernous malformations in children: report of 3 cases

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