Cavernomas of the central nervous system: Clinical syndromes, CT scan diagnosis, and prognosis after surgical treatment in 25 cases

Vaquero, Jesús; Salazar, J; Martínez, R.; Martinez, P.; Bravo, G.

doi:10.1007/bf01402366

Cited by 130 publications

(31 citation statements)

References 14 publications

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“…11,39,51,52 In most series, however, an equal distribution between the sexes 13,24,26,31,40,43,48,53 has been reported, and this was also the case in ours. Some authors have suggested a higher propensity for bleeding episodes in female patients, 16,48 often during pregnancy.…”

Section: Age and Sex Of The Patientssupporting

confidence: 74%

“…23,46 Perilesional hypodensity can be found, and it may represent edema, hemosiderin, or even atrophy. 23,52 The CMs can be present as a cystic lesion that is isodense or hypodense on CT scans, with or without a wall nodule, and consequently, differentiation from posterior fossa gliomas is very difficult based on CT findings alone. 7,23,25 All patients in our series underwent CT scanning.…”

Section: Neuroimaging Findingsmentioning

confidence: 99%

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Neurosurgical management of cerebellar cavernous malformations

Oliveira

Rassi-Neto²,

Ferraz³

et al. 2006

FOC

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Object The aim of this study was to analyze cerebellar cavernous malformations (CMs) with respect to epide-miological, clinical, radiological, and therapeutic aspects. Methods Between 1984 and 2004, 100 patients were surgically treated for intracranial CMs at the Division of Neurosurgery of Federal University of São Paulo. The authors reviewed the records of 10 patients whose lesions were located in the cerebellum. There were four male and six female patients (ratio 1:1.5) whose ages ranged from 14 to 45 years (mean age 33 years). Clinical presentation was sudden or acute in all cases, and neuroimaging examinations performed in all patients demonstrated signs of bleeding. The mean size of the malformations was 4.6 cm, and in all but one patient the lesions were totally removed without complications. After a mean follow-up period of 70 months, all patients were considered to be in good or excellent clinical condition. Conclusions Cerebellar CMs should be analyzed separately from other posterior fossa CMs. These lesions can reach large sizes and cause massive hemorrhages, resulting in acute or sudden presentation. Surgery is a safe and effective option that provides a curative treatment when a complete removal is achieved.

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Section: Age and Sex Of The Patientssupporting

confidence: 74%

Section: Neuroimaging Findingsmentioning

confidence: 99%

Neurosurgical management of cerebellar cavernous malformations

Oliveira

Rassi-Neto²,

Ferraz³

et al. 2006

FOC

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“…Kanama olmuş ise hiperdens gö-rünüm ile birlikte çevresel ödem ve kitle etkisi tespit edilir. Kontrastlı çalışmalarda zayıf bir kontrast tutulumu görülebilir (10,13). Klinik olgularımızın 4'ününde de kompüterize tomografilerinde kanamaya bağlı hiperdens görünüm elde edilmiştir.…”

Section: Discussionunclassified

“…Cerrahi eksizyonun amacı; kanama sonucu gelişen hematoma bağlı gör-me keskinliğinin giderilmesi, lezyonun histopatolojik natürünün tespit edilmesi ve yeniden kanamayı önlemeye yöneliktir (1,2,4,8,10,11,12,13,14,15). Orbital kavernöz anjiomlarda gelişen görme kaybının giderilmesi için cerrahi girişim geciktirilmemelidir.…”

Section: Discussionunclassified

İntraorbi̇tal Kavernöz Anji̇omlar

Haluk;YÜCEER¹

1995

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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“…Patients frequently are asymptomatic (40,70%) (3, 11, 12); symptomatic subjects typically present between ages 20 and 40, although symptoms can begin at any age (6,7,13). Patients commonly present with seizures (7, 14), brain hemorrhage (3,6,11,(13)(14)(15)(16)(17), focal neurological deficits (6, 11-13, 15), or headaches. Risk of bleeding from these lesions is in part dependent on age and the prior occurrence of hemorrhage from the same lesion (15,18).…”

mentioning

confidence: 99%

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.

Günel

Awad

Anson

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

180

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Cerebral cavernous malformation is a common disease of the brain vasculature of unknown cause characterized by dilated thin-walled sinusoidal vessels (caverns); these lesions cause varying clinical presentations which include headache, seizure, and hemorrhagic stroke. This disorder is frequently familial, with autosomal dominant inheritance. Using a general linkage approach in two extended cavernous malformation kindreds, we have identified linkage of this trait to chromosome 7qI1.2-q21. Multipoint linkage analysis yields a peak logarithm of odds (lod) score of 6.88 with zero recombination with locus D7S669 and localizes the gene to a 7-cM region in the interval between loci ELN and D7S802.Vascular malformations are a heterogeneous group of disorders that affect an estimated 0.1-4% of the population (1, 2). Cerebral cavernous malformation (CCM) (also known as angiomas, cavernous angiomas, cavernous hemangiomas, cavernous angiomatomas, or cavernomas) accounts for 10-20% of all vascular malformations (1, 3). These lesions are characterized by collections of large, abnormal vascular spaces without intervening brain parenchyma (2). These thin-walled vascular channels or caverns are lined by endothelium and vary widely in size (Fig. 1). There are no identifiable mature vessel-wall elements within lesions, and there is almost always evidence of prior hemorrhage characterized by hemosiderin accumulation. Although solitary lesions are most commonly found, multiple lesions have been reported in 33% of the sporadic cases and in 50-73% of the familial cases (3-6). The size of these lesions varies from millimeters to centimeters, with a mean size at diagnosis of about 2 cm (1, 7). Cavernous malformation lesions are dynamic in time; subjects have been shown to acquire new lesions, and lesions have also been shown to undergo spontaneous involution. The variable behavior of these lesions is believed to account for the variable clinical course of affected subjects (6,(8)(9)(10).Clinical sequelae of these lesions are variable. Patients frequently are asymptomatic (40,70%) (3, 11, 12); symptomatic subjects typically present between ages 20 and 40, although symptoms can begin at any age (6,7,13). Patients commonly present with seizures (7, 14), brain hemorrhage (3,6,11,(13)(14)(15)(16)(17), focal neurological deficits (6, 11-13, 15), or headaches. Risk of bleeding from these lesions is in part dependent on age and the prior occurrence of hemorrhage from the same lesion (15,18). Diagnosis is usually made by MRI of the brain, which reveals a characteristic image of heterogeneous signal intensity surrounded by a dark ring attributable to hemosiderin deposition ( Fig. 1) (8, 19). Treatment options range from observation in asymptomatic subjects, to pharmacologic therapy inThe publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. subjects with seizures, and surgical excision of ...

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Cavernomas of the central nervous system: Clinical syndromes, CT scan diagnosis, and prognosis after surgical treatment in 25 cases

Cited by 130 publications

References 14 publications

Neurosurgical management of cerebellar cavernous malformations

Neurosurgical management of cerebellar cavernous malformations

İntraorbi̇tal Kavernöz Anji̇omlar

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.

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