Cavernous antioxidant effect of green tea, epigallocatechin-3-gallate with/without sildenafil citrate intake in aged diabetic rats

Mostafa, Taymour; Sabry, Dina; Abdelaal, Amr; Mostafa, Ingi A.; Taymour, Mai

doi:10.1111/and.12005

Cited by 16 publications

(9 citation statements)

References 46 publications

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“…These changes were not visualized in the animals of the green tea groups, suggesting that polyphenols in green tea may also have a positive effect on the ADP, even with induction. Similar results were found in old or diabetic animals, where administration of green tea was seen to reduce oxidation effects, decreasing vascular damage in the penile vasculature [20,38].…”

Section: Discussionsupporting

confidence: 81%

“…Green tea contains five major catechins: catechin, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate (EGCG); the latter comprises more than 40% of the total polyphenolic mixture of green tea catechins. The polyphenols from green tea are capable of altering lipids and cholesterol metabolism and have antioxidant, anti-inflammatory properties [20], cancer, cardiovascular disease prevention [11,21] and anabolic anti-obesity properties [22]. In addition, green tea polyphenols (mainly EGCG) have an anti-androgenic effect, whereby they modulate the metabolism of testosterone [23].…”

Section: Introductionmentioning

confidence: 99%

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Green Tea Consumption Lower Damage and Inflammatory Cytokines in Rat Cardiovascular System Under Androgenic Stimulation

Silva¹,

Boaventura²,

Abboud³

et al. 2019

AJSS

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The abuse of anabolic androgenic steroids by youth and adolescents, athletes and non-athletes, is related to the occurrence of cardiovascular diseases. Contrastingly, green tea prevents and attenuates the cellular damage, improving the biochemical profile and reducing inflammation. This study aims to evaluate the benefits of consuming green tea to attenuate the inflammatory parameters and the cardiovascular damage, which are caused due to supraphysiological doses of testosterone, by analyzing the serological profile and the histoarchitecture of the heart and the arteries of 28 42-day-old male Wistar rats. Silicone pellets containing testosterone were surgically implanted and replaced every four weeks. After 20 weeks, all the male rats were anesthetized and their blood samples collected for serological analysis. Fragments of the aorta, left cardiac ventricle and penis were excised and processed to paraffin. To access morphometrical and stereological parameters, tissue fragments were stained and the images analyzed employing Image J software. The rats consuming green tea exhibited a reduction in aorta wall thickness (22%), luminal area (40%) and wall area (52%), with a lower number of elastic lamella. The dorsal artery of the penis presented with a higher wall area and lower luminal area in induced group compared to the other three groups. Tea consumption also led to a significant reduction in the left ventricle thickness with no increase in volumetric density of collagen fibers. Inflammatory cytokines were also shown to have increased in induced group, indicating cardiovascular risk due to their exposure to testosterone. Except for the endothelial vascular growth factor, this effect was not observed in the groups that consumed tea. It can be concluded that the consumption of green tea has a protective effect on the morphology of cardiovascular tissues and reduces inflammatory indicators, which points out this food as an agent capable of reducing cardiovascular disease risk factors related to high doses of anabolic androgenic steroids.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Green Tea Consumption Lower Damage and Inflammatory Cytokines in Rat Cardiovascular System Under Androgenic Stimulation

Silva¹,

Boaventura²,

Abboud³

et al. 2019

AJSS

View full text Add to dashboard Cite

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“…Roposo et al (2015) reported that EGCG intake (2 g/L in water) could prevent STZ-induced diabetic neuropathic pain via normalizing the increase of 8-hydroxy-2′-deoxyguanosine (8-OHdG) though the neurobiological mechanisms is still unknown. Mostafa et al (2013) demonstrated that a lower concentration of EGCG (7.6 mg/L in water) significantly increased glutathione peroxidase (GPx) and decreased the cavernous MDA compared with diabetic rats. EGCG also showed therapeutic potential on renal damage via suppressing hyperglycemia, proteinuria, and lipid peroxidation in diabetic nephropathy model rats treated with STZ ( Yamabe et al, 2006 ).…”

Section: Protection Of Egcg In Stz-induced Diabetes and Admentioning

confidence: 99%

“… Yamabe et al (2006) found that EGCG had a positive effect on serum glucose and lipid metabolic abnormalities in STZ injection-induced diabetes. EGCG intake from drinking water also showed a glucose-lowering effect in STZ injection-induced diabetes rats ( Mostafa et al, 2013 ). Lipophilic EGCG derivative also showed antidiabetic activities, including reducing the plasma glucose and promoting lipid metabolism, in STZ-induced diabetic rats ( Li et al, 2007 ).…”

Section: Protection Of Egcg In Stz-induced Diabetes and Admentioning

confidence: 99%

Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models

et al. 2017

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Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD.

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“…The antioxidant vitamins are the most important free‐radical scavengers in extracellular fluids, trapping radicals in the aqueous phase and protect biomembranes from peroxidative damage (Sulak et al ., ; Mostafa et al ., , ). However, few studies on the protective effects of antioxidants against the toxic effects of the pyrethroids on human spermatozoa are available.…”

Section: Introductionmentioning

confidence: 99%

In vitrostudy of cypermethrin on human spermatozoa and the possible protective role of vitamins C and E

et al. 2013

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Cypermethrin, a type II synthetic pyrethroid pesticide, is widely used in pest control programmes in agriculture and public health. This study aimed to assess the potential effect of cypermethrin on human spermatozoa and the possible ameliorative effects of vitamins C and E. Semen samples of 20 healthy normozoospermic men were divided into six aliquots at room temperature. The first aliquot served as control not exposed to treatments, and the second was incubated with 20 mm vit. C and 2 mm vit. E where the third one was exposed to 10 μm cypermethrin for 6 h. The other three aliquots were incubated with vit. C, vit. E and both vitamins for 30 min before cypermethrin exposure. Semen aliquots were analysed for sperm motility, sperm viability, hypo-osmotic swelling test and modified alkaline comet assay. The results demonstrated a significant decrease in sperm motion, sperm function and increased sperm DNA damage in the cypermethrin group. Addition of vitamins C and E alone/combined led to significant improvement in sperm motion, sperm function and DNA damage, being maximal with both vitamins together. It is concluded that in vitro cypermethrin can alter sperm function and induce DNA damage in spermatozoa, which is improved after using vitamins C and E.

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Cavernous antioxidant effect of green tea, epigallocatechin-3-gallate with/without sildenafil citrate intake in aged diabetic rats

Cited by 16 publications

References 46 publications

Green Tea Consumption Lower Damage and Inflammatory Cytokines in Rat Cardiovascular System Under Androgenic Stimulation

Green Tea Consumption Lower Damage and Inflammatory Cytokines in Rat Cardiovascular System Under Androgenic Stimulation

Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models

In vitrostudy of cypermethrin on human spermatozoa and the possible protective role of vitamins C and E

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