We report unique regressive changes in a large, non-gravid uterine leiomyoma of a 32 year old lady who, before 2015, had had seven recurrent spontaneous, alternating with assisted pregnancies, over a 7-year period (2008-1015 AD). In formalinfixed status, cut surface of the leiomyoma showed a sponge-like appearance. Pathogenesis of resultant degenerative changes in respect of repeated hormonal hits is discussed, together with review of the literature. To our knowledge, such extreme multi-cystic change in leiomyoma with spongy appearance has not been previously reported.