Cavitary choroidal melanoma

Becerra, Emiliano M.; Saornil, María A.; Blanco, Gonzalo; Méndez, María; Muiños, Y; Esteban, María R.

doi:10.1016/s0008-4182(05)80057-2

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Ultrasonographically, cavitations present as single or multiple, hollow, cystic-like cavities surrounded by a thick reflective wall [4, 5]. Uncommonly, they may be solid lesions with single or multiple acoustically hollow areas.…”

Section: Discussionmentioning

confidence: 99%

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

et al. 2018

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Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Excisional biopsy confirmed cavitary melanoma of the iris. This is the first reported case of cavitation in a primary iris melanoma. The patient has not had any further adjuvant treatment and remains metastasis free at 5 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

et al. 2018

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“…In contrast to retinal detachment, necrosis and inflammation are better depicted on T2weighted imaging, as is illustrated in Figure 3 [22,56]. Using the aforementioned features, The signal intensity characteristics of UM on these types of MR-images have been described extensively [10,11,26,28,34,36,37,45,56,[59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76]. As almost all intraocular lesions, including UM, are hyperintense on T1-and hypointense on T2-weighted imaging compared to the vitreous, Ferreira [28] proposed to use the choroid and nearby extraocular muscle as reference on T1-and on T2-weighted imaging, respectively.…”

Section: Anatomical Evaluationmentioning

confidence: 99%

Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective

Jaarsma-Coes

Klaassen

Marinković

et al. 2023

Cancers

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Conversely to most tumour types, magnetic resonance imaging (MRI) was rarely used for eye tumours. As recent technical advances have increased ocular MRI’s diagnostic value, various clinical applications have been proposed. This systematic review provides an overview of the current status of MRI in the clinical care of uveal melanoma (UM) patients, the most common eye tumour in adults. In total, 158 articles were included. Two- and three-dimensional anatomical scans and functional scans, which assess the tumour micro-biology, can be obtained in routine clinical setting. The radiological characteristics of the most common intra-ocular masses have been described extensively, enabling MRI to contribute to diagnoses. Additionally, MRI’s ability to non-invasively probe the tissue’s biological properties enables early detection of therapy response and potentially differentiates between high- and low-risk UM. MRI-based tumour dimensions are generally in agreement with conventional ultrasound (median absolute difference 0.5 mm), but MRI is considered more accurate in a subgroup of anteriorly located tumours. Although multiple studies propose that MRI’s 3D tumour visualisation can improve therapy planning, an evaluation of its clinical benefit is lacking. In conclusion, MRI is a complementary imaging modality for UM of which the clinical benefit has been shown by multiple studies.

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“…Cavitary melanomas are characterized by single (unilocular) or multiple (multilocular) cystlike cavities with typically thick walls. At histopathology the cavities may contain serous fluid, pigment-laden macrophages or erythrocytes, but do not represent areas of necrosis [55][56][57]. At MRI the cystic spaces are isointense with the vitreous body and therefore appear hypointense on T1-weighted images and hyperintense on T2-weighted images; the thick septa are isointense with the surrounding neoplastic tissue [56].…”

Section: Mr Imaging With Pathologic Correlationmentioning

confidence: 99%

“…At MRI the cystic spaces are isointense with the vitreous body and therefore appear hypointense on T1-weighted images and hyperintense on T2-weighted images; the thick septa are isointense with the surrounding neoplastic tissue [56]. Cavitary melanomas should not be confused with benign uveal cavitary lesions, such as ciliary body cysts (the latter generally smaller than cavitary melanomas and bounded by thin walls) in order to avoid delayed adequate treatment [21,[55][56][57].…”

Section: Mr Imaging With Pathologic Correlationmentioning

confidence: 99%

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations

Foti¹,

Travali²,

Farina³

et al. 2021

Insights Imaging

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Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas.

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Cavitary choroidal melanoma

Cited by 9 publications

References 6 publications

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations

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