Cavitary melanoma of the ciliary body A study of eight cases

Lois, Noemi; Shields, Carol L.; Shields, Jerry A.; Eagle, Ralph C.; Potter, Patrick De

doi:10.1016/s0161-6420(98)96013-4

Cited by 39 publications

(39 citation statements)

References 14 publications

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“…The favoured hypothesis for the development of cavitary changes in malignant melanomas is tumour necrosis and haemorrhage [2, 6, 7]. It is postulated that an imbalance between blood supply and tumour growth could lead to necrosis and tissue reabsorption [2]. Some authors speculate the accumulation of muco-proteinaceous substances or serous exudation may play a role [6-9].…”

Section: Discussionmentioning

confidence: 99%

“…Although advancement in imaging modalities allows more detailed analysis of intraocular lesions, they can occasionally present with atypical features causing diagnostic dilemma. Cavitation is known to occur in less than 1% of intraocular melanomas and is most common in the ciliary body [1, 2]. The ultrasound findings can be difficult to differentiate from those of a benign epithelial cyst.…”

Section: Novel Insightsmentioning

confidence: 99%

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A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

et al. 2018

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Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Excisional biopsy confirmed cavitary melanoma of the iris. This is the first reported case of cavitation in a primary iris melanoma. The patient has not had any further adjuvant treatment and remains metastasis free at 5 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Novel Insightsmentioning

confidence: 99%

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

et al. 2018

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“…One of our cases (14%) had a cavitary appearance. Cavitation has been reported to occur in ciliary body melanoma [10, 11]. In some cases, cavitary spaces may develop after necrosis of the tumor as a result of the imbalance between blood supply and tumor growth.…”

Section: Discussionmentioning

confidence: 99%

“…In some cases, cavitary spaces may develop after necrosis of the tumor as a result of the imbalance between blood supply and tumor growth. In other cases, cavitary spaces are filled with serous fluid, erythrocytes or pigment-laden macrophages [11]. The presence of thick-walled cysts in a predominantly solid ciliary body lesion on UBM should be considered as a suspicious sign for malignancy.…”

Section: Discussionmentioning

confidence: 99%

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The Use of Ultrasound Biomicroscopy in the Evaluation of Anterior Segment Tumors and Simulating Conditions

et al. 2007

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Purpose: To report the ultrasound biomicroscopy (UBM) findings of anterior segment tumors and simulating conditions. Methods: Thirty-five patients underwent UBM. Of those, 16 had histopathologically or cytopathologically diagnosed tumors, and 19 had clinically diagnosed lesions. Results: The study material comprised 13 iris pigment epithelial (IPE) cysts, 7 ciliary body melanomas, 4 iris melanomas, 4 iris nevi, 3 intraocular invasions of conjunctival squamous cell carcinoma, 2 ring melanomas of the anterior chamber angle, 1 medulloepithelioma and 1 pars plana cyst. On UBM, all IPE cysts presented as cystic lesions with a thin cyst wall and no solid components. All ciliary body melanomas showed low to medium reflectivity, with cavitation in one case and extraocular extension in another. Iris melanomas presented as anterior (stromal) iris lesions with medium to high internal reflectivity. There was irregularity and convex bowing of the posterior iris plane in iris melanomas, a feature not seen in iris nevi. Intraocular invasion of conjunctival squamous cell carcinoma was evidenced as areas of medium to high reflectivity in the ciliary body and iris, loss of the acute angle shape and highly reflective spots in the anterior chamber. Conclusions: UBM was particularly useful in the diagnosis of IPE cysts, in the visualization of small ciliary body melanomas, in the differentiation of iris melanomas from iris nevi and in the demonstration of intraocular invasion from conjunctival squamous cell carcinoma.

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Cavitary Melanoma of Ciliary Body Simulating a Cyst

Zhang¹

2005

Arch Ophthalmol

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Cavitary melanoma of the ciliary body A study of eight cases

Cited by 39 publications

References 14 publications

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation

The Use of Ultrasound Biomicroscopy in the Evaluation of Anterior Segment Tumors and Simulating Conditions

Cavitary Melanoma of Ciliary Body Simulating a Cyst

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