Cavitation Induced Damage in Soft Biomaterials

Hasan, Fuad; Mahmud, K.A.H. Al; Khan, Ishak; Patil, Sandeep; Dennis, Brian H.; Adnan, Ashfaq

doi:10.1007/s42493-021-00060-x

Cited by 24 publications

(12 citation statements)

References 60 publications

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“…26,44 In addition, both κ s and κ b show the same trend, that is, their values decrease as the ratio of oxidized lipids (OxDOPC) increases. This variation in modulus indicates that the membrane with 100% peroxidation degree has a lower resistance to shock and damaging energy threshold 45 (the corresponding energy threshold I c = 123.63 MJ. For calculation details of I c , please refer to the Supporting Information).…”

Section: ■ Discussionmentioning

confidence: 98%

Impact of Shock-Induced Cavitation Bubble Collapse on the Damage of Cell Membranes with Different Lipid Peroxidation Levels

Wei

Zhou

et al. 2021

J. Phys. Chem. B

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Although the interaction mechanism between shock waves and cells is critical for advancing the medical applications of shock waves, we still have little understanding about it. This work aims to study the response of diseased cells subjected to lipid peroxidation to the nanojet from shock wave-induced bubble collapse by using the coarse-grained molecular dynamics simulation. Factors considered in the simulations include the shock velocity (u p), movement time of piston (τp), bubble size (R), and peroxidation level of membranes. Here, we mainly focus on the role of peroxidation levels, that is, the degree (%) and the distribution of oxidized lipids in membranes. The results indicate that the shock damage threshold (u p at which the pore in membranes is formed) of peroxidation membranes is less than that of normal membranes and decreases with the peroxidation degree. Importantly, the distribution of oxidized lipids has more effect on the damage threshold than the peroxidation degree. The threshold of membrane with 33% localized oxidized lipids is lower than that of membrane with 50% average oxidized lipids. The results can be explained by the stretching modulus (κs) and bending modulus (κb) of cell membranes. For example, the κb value (4.3 × 10–20 J) of 100% peroxidation membrane is about half of that (8.4 × 10–20 J) of a membrane without peroxidation. A lower modulus means high deformation under the same impact. Further analysis shows that peroxidation introduces a polar hydrophobic group to the tail of phospholipids that increases the hydrophilicity of tails and warps the tail of phospholipids toward the membrane–water interface, resulting in looser accumulation. This can be confirmed by the increased average phospholipid area with peroxidation levels. Indeed, most of the pores formed during the shock can heal. However, the permeation of water molecules across the healing membrane still increased. All these membrane-level information obtained from this study will be useful for improving the biomedical applications of shock waves.

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Section: ■ Discussionmentioning

confidence: 98%

Impact of Shock-Induced Cavitation Bubble Collapse on the Damage of Cell Membranes with Different Lipid Peroxidation Levels

Wei

Zhou

et al. 2021

J. Phys. Chem. B

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“…3 e and 4e). According to the Rayleigh-Plesset equation, cavitation activity in a liquid strongly depends on other properties of the liquid, such as viscosity, surface tension and density [45] , [46] , [47] , [48] . The growth of transient nano-sized bubbles is greatly affected by the viscosity of the liquid [45] .…”

Section: Resultsmentioning

confidence: 99%

Ultrasonic cavitation in CO2-expanded N, N-dimethylformamide (DMF)

Gao

Pei

Dong

et al. 2021

Ultrasonics Sonochemistry

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Highlights Ultrasonic cavitation is recorded by high-speed camera and hydrophone in a gas-expanded liquid system. Content of CO 2 has an important influence on evolution of bubble cloud. Cavitation intensity depends on ultrasonic power and gas content. The combination of ultrasound and gas-expanded liquid system greatly promotes mass transfer.

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“…In short, current literature lacks insight in mechanical behavior of axonal actin, spectrin, and actinspectrin interaction. However, recent studies on axonal cytoskeletal components have focused on applicable strain rate on soft biomaterials [147][148][149] relevant to brain and different cytoskeletal components such as microtubules, tau proteins, and neurofilaments [150][151][152][153]. Such extreme high strain rate scenarios can be captured by undertaking atomistic computational approaches which can be extended to other axonal cytoskeletal components to provide novel insights regarding the specific mechanical behavior of them at extreme strain rate.…”

Section: Periodic Actin-spectrin Skeleton: Role In Axon and Strain Ra...mentioning

confidence: 99%

Mechanical Behavior of Axonal Actin, Spectrin, and Their Periodic Structure: A Brief Review

Khan

Ferdous

Adnan

2021

Multiscale Sci. Eng.

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Actin and spectrin are important constituents of axonal cytoskeleton. Periodic actin-spectrin structures are found in dendrites, initial segment of axon, and main axon. Actin-spectrin periodicity has been hypothesized to be manipulating the axon stability and mechanical behavior. Several experimental and computational studies have been performed focusing on the mechanical behavior of actin, spectrin, and actin-spectrin network. However, most of the actin studies focus on typical long F-actin and do not provide quantitative comparison between the mechanical behavior of short and long actin filaments. Also, most of the spectrin studies focus on erythrocytic spectrin and do not shed light on the behavior of structurally different axonal spectrin. Only a few studies have highlighted forced unfolding of axonal spectrin which are relevant to brain injury scenario. A comprehensive, strain rate dependent mechanical study is still absent in the literature. Moreover, the current opinions regarding periodic actin-spectrin network structure in axon are disputed due to conflicting results on actin ring organizationas argued by recent super-resolution microscopy studies. This review summarizes the ongoing limitations in this regard and provides insights on possible approaches to address them. This study will invoke further investigation into relevant high strain rate response of actin, spectrin, and actin-spectrin networkshedding light into brain pathology scenario such as traumatic brain injury (TBI).

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Cavitation Induced Damage in Soft Biomaterials

Cited by 24 publications

References 60 publications

Impact of Shock-Induced Cavitation Bubble Collapse on the Damage of Cell Membranes with Different Lipid Peroxidation Levels

Impact of Shock-Induced Cavitation Bubble Collapse on the Damage of Cell Membranes with Different Lipid Peroxidation Levels

Ultrasonic cavitation in CO2-expanded N, N-dimethylformamide (DMF)

Mechanical Behavior of Axonal Actin, Spectrin, and Their Periodic Structure: A Brief Review

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