CAY-I, a novel antifungal compound from cayenne pepper

Renault, Samantha; Lucca, Anthony J. De; Boué, Stephen M.; Bland, J. M.; Vigo, C. B.; Selitrennikoff, Claude P.

doi:10.1080/mmy.41.1.75.82

Cited by 33 publications

(18 citation statements)

References 20 publications

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“…Earlier studies 9 presented data showing that EDTA enhanced the activity of some antifungal compounds. EDTA enhances lactoferrin and amphotericin B activity against Escherichia coli O157 : H7 and Aspergillus species respectively 9–21 . Some of the goals of the present study were to determine whether EDTA would (a) significantly reduce the viability of the test fungi under the stated in vitro test conditions and (b) enhance the in vitro fungicidal activity of CAY‐1 employed at sub‐lethal concentrations against the six Aspergillus and Fusarium species.…”

Section: Discussionmentioning

confidence: 98%

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Silver enhances the in vitro antifungal activity of the saponin, CAY-1

Lucca

Boué

Sien

et al. 2009

Mycoses

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The fungicidal properties of purified CAY-1, dissolved silver ion and ethylenediamine tetraacetic acid (EDTA) separately were studied in vitro as were the abilities of silver and EDTA to enhance CAY-1 fungicidal properties. Non-germinated and germinating conidia of Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Fusarium verticillioides (Fusarium moniliforme), Fusarium oxysporum and Fusarium solani were incubated separately with CAY-1 (0-24.8 μg ml(-1)), silver (0-111.1 μg ml(-1)), and EDTA (0-2400 μg ml(-1)). Controls consisted of non-germinated or germinated conidia in test medium. To assess combined activity, compounds, based on the sub-lethal doses of each as defined in the initial experiments, were combined and tested in bioassays. Controls for the mixed sets consisted of non-germinated or germinated conidia only or with the sub-lethal CAY-1 test concentrations. The minimum inhibitory concentrations (MICs) for CAY-1 and silver, both separate and combined, were determined. Viability assays showed CAY-1 activity only against the germinating conidia of A. flavus, A. niger and F. solani. Silver was active against the germinating conidia of all fungi and the non-germinated conidia of F. oxysporum and F. solani. Combined silver and CAY-1 produced significant viability loss at concentrations not effective separately. EDTA was not fungicidal separately and did not enhance CAY-1 fungicidal properties. MIC data showed that CAY-1 plus silver had an additive effect. Results indicate that dissolved silver was fungicidal in vitro and enhanced the fungicidal properties of CAY-1 at concentrations ineffective when tested separately.

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Section: Discussionmentioning

confidence: 98%

“…In vitro , it is active against several Aspergillus and Candida species as well as Cryptococcus neoformans and Pneumocystis carinii. 10,11 The antimicrobial properties of saponins are based upon their ability to interact with cell walls and membranes resulting in cell lysis 12 …”

Section: Introductionmentioning

confidence: 99%

Silver enhances the in vitro antifungal activity of the saponin, CAY-1

Lucca

Boué

Sien

et al. 2009

Mycoses

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“…The active ingredient in cayenne is capsaicin, although carotenoids, flavonoids and vitamins A and C have also been reported to play active roles in its use as a medicine (Ahuja et al 2006). Cayenne pepper has reportedly been used in ethnomedicinal practices of postnatal care, as nutrition therapy, in pain management, to treat erectile dysfunction, as a circulatory tonic, as a remedy for rheumatic and arthritic pains, in the reduction of blood sugar levels, for the excretion of cholesterol, as well as for its analgesic, antimicrobial, anti-inflammatory and immunological effects (Renault et al 2003;Ahuja et al 2006;Nwose 2009;Jolayemi & Ojewole 2013).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of combined spices ofAllium sativum,Zingiber officinaleandCapsicum frutescensin alloxan-induced diabetic rats

Otunola

Afolayan

2015

Frontiers in Life Science

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Allium sativum (garlic), Zingiber officinale (ginger) and Capsicum frutescens (cayenne pepper) are common dietary spices also traditionally used in the treatment of various diseases including diabetes mellitus. The antidiabetic activity of each individual spice is well documented, but their effect when combined is unknown. Polyherbalism is of current interest because polyherbal formulations enhance therapeutic action and reduce the concentrations of single herbs, thereby reducing adverse events. This study evaluated the hypoglycaemic activity of aqueous extract of combined garlic, ginger and cayenne pepper (GGCP) at different doses in alloxan-induced diabetic rats. Diabetic rats were treated with GGCP at 200 mg and 500 mg/kg body weight/day, or glibenclamide (5 mg/kg body weight/day) for 7 days. GGCP extract significantly (p < 0.05) lowered the elevated fasting blood glucose, lipid and haematological indices. The mixture markedly attenuated cellular toxicity, and reduced tubular degeneration and necrosis in the kidney, fatty degeneration and necrosis in the liver and pancreatic hyperplasia in diabetic rats. These effects were more pronounced at 500 mg/kg and equipotent with glibenclamide, suggesting that in addition to its hypoglycaemic activity, GGCP protects the blood, kidney, liver and pancreas against diabetic injury. This is the first pilot study to evaluate a possible role for this spice mixture in the treatment of diabetes.

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“…CAY-1, a novel triterpene saponin from the Capsicum frutescens L. (Solanaceae) plant commercially known as cayenne pepper, was investigated to determine its in vitro antifungal activity. 110 CAY-1 was active against sixteen different fungal strains, including Candida spp. and…”

Section: Saponinsmentioning

confidence: 99%

Active antifungal substances from natural sources

Abad¹,

Ansuategui²,

Bermejo³

2006

Arkivoc

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The spread of multidrug-resistant strains of fungus and the reduced number of drugs available, makes it necessary to discover new classes of antifungals and compounds that inhibit these resistant mechanisms. This has led to a search for therapeutic alternatives, particularly among medicinal plants and compounds isolated from them used for their empirically antifungal properties. In these natural sources, a series of molecules with antifungal activity against different strains of fungus have been found, which are of great importance to humans and plants. In this article, we review the main sources of molecules with antimycotic activity obtained from the natural environment.

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CAY-I, a novel antifungal compound from cayenne pepper

Cited by 33 publications

References 20 publications

Silver enhances the in vitro antifungal activity of the saponin, CAY-1

Silver enhances the in vitro antifungal activity of the saponin, CAY-1

Antidiabetic effect of combined spices ofAllium sativum,Zingiber officinaleandCapsicum frutescensin alloxan-induced diabetic rats

Active antifungal substances from natural sources

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