2023
DOI: 10.1097/fbp.0000000000000759
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CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice

Oualid Abboussi,
Zmarak Ahmad Khan,
Hind Ibork
et al.

Abstract: Chronic exposure to cocaine is known to have profound effects on the brain, leading to the dysregulation of inflammatory signalling pathways, the activation of microglia, and the manifestation of cognitive and motivational behavioural impairments. The endocannabinoid system has emerged as a potential mediator of cocaine’s deleterious effects. In this study, we sought to investigate the therapeutic potential of the cannabinoid CB2 receptor agonist, JWH-133, in mitigating cocaine-induced inflammation and associa… Show more

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