CB2 cannabinoid receptor mediation of antinociception

Ibrahim, Mohab; Rude, Megan L.; Stagg, Nicola J.; Mata, Heriberto P.; Lai, Josephine; Vanderah, T. W.; Porreca, F; Buckley, Nancy E.; Makriyannis, A.; Malan, T. Phillip

doi:10.1016/j.acpain.2006.08.026

Cited by 25 publications

(37 citation statements)

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“…The anti-nociceptive action of CB2 agonists and inverse agonists has been previously demonstrated [2,36,81]. Our present molecular data highlight the role of CB2, as suggested by its overexpression following CCI, observed here.…”

Section: Discussionsupporting

confidence: 72%

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

Małek

Kostrzewa

Makuch

et al. 2016

Pharmacological Research

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Section: Discussionsupporting

confidence: 72%

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

Małek

Kostrzewa

Makuch

et al. 2016

Pharmacological Research

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“…Malan et al [42] demonstrated that the CB 2 receptor selective agonist AM1241 increased hind-paw thermal withdrawal latency; an effect which was blocked by the CB 2 receptor selective antagonist AM630, but not by the CB 1 receptor selective antagonist AM251, indicating mediation by CB 2 receptors. This was further confirmed in a later study, which demonstrated that the anti-nociceptive effects of AM1241 were absent in CB 2 receptor-null mice [49]. Importantly, Malan and coworkers have demonstrated that AM1241-mediated anti-nociception was devoid of CNS side effects, as indicated by the lack of effects on immobility/catalepsy, locomotor activity and hypothermia [42].…”

Section: Antinociceptive Effects Of Cb 2 Receptor Agonists In Models mentioning

confidence: 87%

Cannabinoid CB2 Receptor-Mediated Anti-nociception in Models of Acute and Chronic Pain

et al. 2007

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The endocannabinoid system consists of cannabinoid CB(1) and CB(2) receptors, endogenous ligands and their synthesising/metabolising enzymes. Cannabinoid receptors are present at key sites involved in the relay and modulation of nociceptive information. The analgesic effects of cannabinoids have been well documented. The usefulness of nonselective cannabinoid agonists can, however, be limited by psychoactive side effects associated with activation of CB(1) receptors. Following the recent evidence for CB(2) receptors existing in the nervous system and reports of their up-regulation in chronic pain states and neurodegenerative diseases, much research is now aimed at shedding light on the role of the CB(2) receptor in human disease. Recent studies have demonstrated anti-nociceptive effects of selective CB(2) receptor agonists in animal models of pain in the absence of CNS side effects. This review focuses on the analgesic potential of CB(2) receptor agonists for inflammatory, post-operative and neuropathic pain states and discusses their possible sites and mechanisms of action.

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“…However, they show deficiency in some B-and T-cell subsets and lack immunomodulation by cannabinoids [7,8]. CB 2 R knockout mice are more susceptible to liver fibrosis, pain and neuroinflammation and they show more age-related bone loss [9][10][11][12].…”

Section: Introductionmentioning

confidence: 98%

Non-Invasive Imaging of the Type 2 Cannabinoid Receptor, Focus on Positron Emission Tomography

Evens¹,

Bormans²

2010

CTMC

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The type 2 cannabinoid receptor (CB 2 R) is a relatively new target for drug development, as the receptor was only discovered in 1993. The CB 2 R is mainly expressed in tissues and organs related to the immune system. However, in pathological conditions, mostly inflammatory, a strong upregulation has been observed. Because of its expression in activated microglia, the type 2 cannabinoid receptor might play an important role in pathologies with a neuroinflammatory component. Positron emission tomography provides a sensitive non-invasive imaging technique to study and quantify receptor expression. In this review, the importance of CB 2 R imaging, the current status and the future possibilities for the development of CB 2 R PET radioligands are discussed.

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CB2 cannabinoid receptor mediation of antinociception

Cited by 25 publications

References 0 publications

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

Cannabinoid CB2 Receptor-Mediated Anti-nociception in Models of Acute and Chronic Pain

Non-Invasive Imaging of the Type 2 Cannabinoid Receptor, Focus on Positron Emission Tomography

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