2021
DOI: 10.1016/j.jpba.2021.114344
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CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up

Abstract: Quality control of CBD oils on the Belgium market showed that the CBD content not always corresponds to the label claim. There is a pressing need to develop new analytical methods specifically developed to the assay of such oily samples. Analytical issues are, however, encountered for routine analyses due to the matrix complexity, high cost of cannabinoid standards and low Δ9-THC concentrations. An oily matrix could cause technical damages to analytical instruments and reduce the lifetime of the chromatographi… Show more

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Cited by 13 publications
(18 citation statements)
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“…CBD oil is divided according to 9-THC concentration [69]. Some claim that hemp oil should not contain cannabinoids because it is produced for mass consumption, yet testing for 9-THC is not routinely performed [30].…”
Section: Source Of Cannabinoidsmentioning
confidence: 99%
See 1 more Smart Citation
“…CBD oil is divided according to 9-THC concentration [69]. Some claim that hemp oil should not contain cannabinoids because it is produced for mass consumption, yet testing for 9-THC is not routinely performed [30].…”
Section: Source Of Cannabinoidsmentioning
confidence: 99%
“…One should appreciate a yin and yang approach to cannabinoids, considering the many different aspects of their narrative. Cannabinoids often exhibit opposite actions depending on the exact compound studied, their enantiomers, species used to study the compound, or overall health status [26][27][28][29][30]. Their social acceptance and legal approval vary greatly [25,31,32].…”
Section: Introductionmentioning
confidence: 99%
“…7,8,10,11,13,[15][16][17][18][19] Methods with QuEChERS clean-up are already established. 18,20 To clarify whether hemp products contain THC or other cannabinoids relevant for doping control, a GC-MS-based detection method for various cannabinoids in food and nutritional supplements was developed and validated. A total of 23 different commercially available hemp products (oils, teas, beer, sweets, spread, and seeds) were tested for the presence or absence of the selected cannabinoids or metabolites (Table 1).…”
Section: Introductionmentioning
confidence: 99%
“…Since THC concentration in hemp products is the main criterion for marketability, the focus of most publications is THC and CBD concentration, 8,9,12,13,19 generally based on liquid chromatography analyses 7,8,10,11,13,15–19 . Methods with QuEChERS clean‐up are already established 18,20 …”
Section: Introductionmentioning
confidence: 99%
“…Additionally, linear quadrupoles were the first to be commercialized; they are relatively affordable compared to other instrumentation, easily connected with various ion sources, and offer high transmission in single ion monitoring (SIM) mode and scan speeds. For those reasons, triple quadrupole mass analyzers are the gold standards for routine MS analytical laboratories and monitoring specific analytes with defined m/z values and fragmentation patterns (179)(180)(181)(182)(183)(184).…”
Section: Low Resolution -Triple Quadrupole Mass Analyzermentioning
confidence: 99%