CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction

Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination

“…One common variant in CCR2, Val64Ile (rs1799864), has been associated with coronary artery calcium with the rarer 64Ile allele associated with decreased coronary artery calcium independent of sex and other traditional risk factors. 19 This allele has also been associated with early-onset MI 20,21 and heart failure but not coronary atherosclerosis suggesting a less stable plaque morphology due to lack of calcification that may explain increased risk of MI observed in carriers of 64Ile. 20 However, the Val64Ile allele was not associated with MI in a retrospective study of patients in Iceland who survived an MI at 37-69 years of age.…”

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

“…The authors found that CCR2 VI/II genotypes were significantly associated with MI in patients younger than 65 years 53 . Similarly, the relationship of VI genotype with an early onset of MI in females was reported 54 . In both studies, age limitation is in agreement with the recent hypothesis that genetic factors may have impact on MI patients with onset only before the age of 65 years 53,54 .…”

“…Similarly, the relationship of VI genotype with an early onset of MI in females was reported 54 . In both studies, age limitation is in agreement with the recent hypothesis that genetic factors may have impact on MI patients with onset only before the age of 65 years 53,54 . In contrast, no association of this SNP with MI was found in Spanish or Icelandic cohorts 18,55 .…”

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

“…Gene polymorphisms of chemokine MCP-1/CCL2, a molecule that plays an important role in atherosclerosis, and its receptor CCR2 belong to most studied one (Arakelyan et al, 2005;Bucova et al, 2008a;Petrkova et al 2003). MCP-1/CCL2 is a potent chemoattractant for monocytes, T cells and NK cells.…”

“…In addition to several negative roles in the process of atherosclerosis, thrombotic occlusion of a coronary artery and in the process of reperfusion, this chemokine protects myocytes from hypoxia-induced cell death and has also positive effect in myocardial infarct healing (Dewald et al, 2005;Tarzami et al, 2002Tarzami et al, , 2005. Polymorphism of MCP-1 and its receptor CCR2 have been implicated as susceptibility factor for chronic stable angina pectoris, ischemic heart disease and myocardial infarction by several independent investigators (Petrkova et al, 2003;Ortlepp et al, 2003), even in hypertensive ischemic heart disease assymptomatic patients (Penz et al, 2010). An association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease was also found (Cha SH et al, 2007).…”