CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

Abstract

The authors note that on page 13064, right column, first full paragraph, lines 4-7, "Some of the climatic events linked to such concerns are the severe droughts experienced by the Amazon basin in 2005 and 2010, which reportedly reduced tropical forest NPP by 1.6 to 2.2 PgC/y and increased tree mortality (50, 51)" should instead appear as "Some of the climatic events linked to such concerns are the severe droughts experienced by the Amazon basin in 2005 and 2010, which reportedly reduced tropical forest NPP and increased tree mortality by a total biomass carbon loss of 1.6 to 2.2 PgC (50, 51)."On page 13064, right column, first full paragraph, lines 12-17, "Assuming that the large reductions of tropical NPP reported previously (50, 51) are realistic, the absence of marked variations of the global CO 2 growth rate after the 2005 and 2010 Amazon droughts may imply that the drought conditions also coincidently reduced tropical Rh along with NPP, resulting in (relatively) small NEE anomalies" should instead appear as "Assuming that the large reductions of tropical forest biomass reported previously (50, 51) are realistic, the absence of marked variations of the global CO 2 growth rate after the 2005 and 2010 Amazon droughts may imply that the drought conditions also coincidently reduced tropical Rh along with NPP, resulting in (relatively) small NEE anomalies."These changes do not affect the conclusions of the article.

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

“…Pictures of collagen staining were taken to cover the entirety of all sections. Colour intensity of stained areas was analysed semi-quantitatively with ImageJ and expressed as percentage of the surface area essentially as described before 24 25. For details, see the online supplementary method section.…”

Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis

“…This corroborates other studies that showed an increase of PAFR in the onset of different diseases, like systemic infection, necrotizing enterocolitis, graft-vs-host disease and peripheral nerve injury. [23][24][25][26] As expected, initially, the infiltrating immune cells must be responsible for PAFR expression upregulation, and at later time points the renal cells are also responsible for the maintenance of higher PAFR expression. PAF and a wide range of oxidatively modified phospholipids are recognized by PAFR that is constitutively expressed by cells participating in innate immunity.…”

Dabigatran Potentiates Gemcitabine-Induced Growth Inhibition of Pancreatic Cancer in Mice

“…(immuno)histochemistry Histological examination was performed essentially as previously described (29,30). Briefly, the excised tumor was fixed in formalin, embedded in paraffin and 4 μm thick slides were subsequently deparaffinized, rehydrated and washed in deionized water.…”