CCCH-type zinc finger antiviral protein is specifically overexpressed in spleen in response to subgroup J avian leukosis virus infection in chicken

Zhu, Mingjun; Zhou, Jing; Ma, Xiaoqian; Li, Gen; He, Shuhai; Tang, Jing; Yao, Yongxiu; Cheng, Ziqiang

doi:10.1016/j.rvsc.2018.12.017

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…ZAP expression in DF-1 was readily inducible by IFN-β ( Fig. 4 ) and by infection of DF-1 cells and of a wide range of other chicken cell types in vivo ( Zhu et al 2019 ).…”

Section: Discussionmentioning

confidence: 98%

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions

Odon

Fiddaman

Smith

et al. 2022

RNA

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The ability of zinc finger antiviral protein (ZAP) to recognize and respond to RNA virus sequences with elevated frequencies of CpG dinucleotides has been proposed as a functional part of the vertebrate innate immune antiviral response. It has been further proposed that ZAP activity shapes compositions of cytoplasmic mRNA sequences to avoid self-recognition, particularly mRNAs for interferons (IFNs) and IFN-stimulated genes (ISGs) expressed during the antiviral state. We investigated whether restriction of the replication of mutants of influenza A virus (IAV) and the echovirus 7 (E7) replicon with high CpG and UpA frequencies varied in different species of mammals and birds. Cell lines from different bird orders showed substantial variability in restriction of CpG-high mutants of IAV and E7 replicons, whereas none restricted UpA-high mutants, in marked contrast to universal restriction of both mutants in mammalian cells. Dinucleotide representation in ISGs and IFN genes was compared with those of cellular transcriptomes to determine whether potential differences in inferred ZAP activity between species shaped dinucleotide compositions of highly expressed genes during the antiviral state. While mammalian type 1 IFN genes typically showed often profound suppression of CpG and UpA frequencies, there was no oversuppression of either in ISGs in any species, irrespective of their ability to restrict CpG- or UpA-high mutants. Similarly, genome sequences of mammalian and avian RNA viruses were compositionally equivalent, as were IAV strains recovered from ducks, chickens and humans. Overall, we found no evidence for host variability in inferred ZAP function shaping host or viral transcriptome compositions.

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“…ZAP expression in DF-1 was readily inducible by IFN-β ( Fig. 4 ) and by infection of DF-1 cells and of a wide range of other chicken cell types in vivo ( Zhu et al 2019 ).…”

Section: Discussionmentioning

confidence: 98%

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions

Odon

Fiddaman

Smith

et al. 2022

RNA

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“…During MLV infection, ZAP localizes to RNA granules with characteristics of both stress granules and processing bodies (23). ZAP also inhibits the deltaretrovirus human T-lymphotropic virus type-1 (HTLV-1) and the alpharetrovirus avian leukosis virus (35)(36)(37)(38). For both viruses, ZAP appears to target viral RNA transcripts for degradation.…”

Section: Zap Inhibits a Diverse Range Of Virusesmentioning

confidence: 99%

Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System

2021

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The zinc finger antiviral protein (ZAP) restricts the replication of a broad range of RNA and DNA viruses. ZAP directly binds viral RNA, targeting it for degradation and inhibiting its translation. While the full scope of RNA determinants involved in mediating selective ZAP activity are unclear, ZAP binds CpG dinucleotides, dictating at least part of its target specificity. ZAP interacts with many cellular proteins, although only a few have been demonstrated to be essential for its antiviral activity, including the 3′–5′ exoribonuclease exosome complex, TRIM25, and KHNYN. In addition to inhibiting viral gene expression, ZAP also directly and indirectly targets a subset of cellular messenger RNAs to regulate the innate immune response. Overall, ZAP protects a cell from viral infection by restricting viral replication and regulating cellular gene expression. Further understanding of the ZAP antiviral system may allow for novel viral vaccine and anticancer therapy development. Expected final online publication date for the Annual Review of Virology, Volume 8 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…In addition to the well-known ISGs described above, there are many other ISGs like double-stranded RNA-dependent protein kinase (PKR) and zinc finger CCCH-type antiviral protein induced expression changes by DTMUV infection investigated by many some transcriptomic and proteomic studies [ 82 , 102 ], and they all have strong antiviral ability [ 135 , 136 ]. However, whether these ISGs are capable of impairing DTMUV infection is not clear.…”

Section: Dtmuv Infection Triggers Host Innate Immune Responsesmentioning

confidence: 99%

Innate immune responses to duck Tembusu virus infection

Zhao

Yang

et al. 2020

Vet Res

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The disease caused by duck Tembusu virus (DTMUV) is characterized by severe egg-drop in laying ducks. Currently, the disease has spread to most duck-raising areas in China, leading to great economic losses in the duck industry. In the recent years, DTMUV has raised some concerns, because of its expanding host range and increasing pathogenicity, as well as the potential threat to public health. Innate immunity is crucial for defending against invading pathogens in the early stages of infection. Recently, studies on the interaction between DTMUV and host innate immune response have made great progress. In the review, we provide an overview of DTMUV and summarize current advances in our understanding of the interaction between DTMUV and innate immunity, including the host innate immune responses to DTMUV infection through pattern recognition receptors (PRRs), signaling transducer molecules, interferon-stimulated genes (ISGs), and the immune evasion strategies employed by DTMUV. The aim of the review is to gain an in-depth understanding of DTMUV pathogenesis to facilitate future studies.

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CCCH-type zinc finger antiviral protein is specifically overexpressed in spleen in response to subgroup J avian leukosis virus infection in chicken

Cited by 11 publications

References 27 publications

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions

Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System

Innate immune responses to duck Tembusu virus infection

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