CCCXCIV.—Halogenation of anisole derivatives

Metabolic Pathways of 2, 4-Dichloro-1-nitrobenzene in <i>Mucor javanicus</i>

“…Almost all of expected metabolic intermediates from 1 to 5 were thus identified, and timedependent changes of the metabolites hitherto confirmed were followed by the measurement of radioactivity in the metabolic experiment using a 14C-2, 4-DCNB glutathione conjugate (14C-2) and resting cells of M. javanicus. Together with the previous evidence that the glutathione conjugate (2) was identified as an enzymatic reaction product from GSH and 2, 4-DCNB (1) in the cell-free system of the fungus, the results of the present study showed the whole aspect of fungal metabolism of 1 to methylthio-containing products (5,6) and their oxidation products (8)(9)(10)(11).…”

“…The fate of methylsulfinyl-or methylsulf onylsubstituted metabolites (8)(9)(10)(11) in nature remains to be clarified. The fungal metabolism of 2, 4-DCNB (and 2, 3-DCNB) into these compounds, however, may be significant from the view points of an increase in polarity and a decrease in number of chlorine atoms when compared with the substrate.…”

The metabolism of 2:4-, 2:5- and 3:4-dichloronitrobenzene in the rabbit

“…480, by the method of Hodgson & Wignall (1927) from 3:5dichloroaniline prepared accordingto Holleman (1904); 3:6dichloro-2-nitrophenol, m.p. 67-68°, by the method of Hodgson & Kershaw (1929) from 2:5-dichlorophenol prepared as described by Noelting & Kopp (1905); 2:5-dichloro-4-nitrophenol, m.p. 1150, from 2:5-dichloro-4-qitroaniline (Holleman & Haeften, 1921) by decomposition of the diazo compound according to Noelting & Kopp (1905).…”

The metabolism of γ-2,3,4,5,6-pentachlorocyclohex-1-ene and γ-hexachlorocyclohexane in rats

“…Silk of the Jealots Hill Research Station of Imperial Chemical Industries Ltd., Bracknell, Berks. 2,3,5-Trichlorophenol was prepared from 2,4-dichloroaniline as described by Hodgson & Kershaw (1929). 2,3,5-Trichlorophenyl benzoate was obtained as needles from light petroleum (b.p.…”