CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum

Shahid, Sohaib; Shi, Yan; Yang, Chun‐Hong; Li, Jiangjie; Ali, Muhammad Yasir; Smagghe, Guy; Liu, Tong‐Xian

doi:10.1016/j.peptides.2021.170596

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…FLAa3/Lgr3 neurons detect dILP8 and influence sugar 13 ingestion (Meissner et al, 2016, Yeom et al, 2021, Yu et al, 2013. CCHa2 and its receptor CCHa2R have been shown to participate in feeding regulation and regulate insulin signaling, although the function of CCHa2R-RA neurons has not been examined (Deng et al, 2019, Ida et al, 2012, Ren et al, 2015, Sano et al, 2014, Shahid et al, 2021. Thus, BiT synapses onto many neuroendocrine neurons, possibly enabling integration of the hunger and thirst signals sensed by ISNs with diverse nutrient state signals.…”

Section: Bit Downstream Partners Include Neuroendocrine Cells That Co...mentioning

confidence: 99%

“…A number of studies indicate that CCHa2 and its receptor CCHa2R promote food intake and appetite in various insects, including blowflies (Ida et al, 2012), aphids (Shahid et al, 2021) and Drosophila (Ren et al, 2015). BiT synapses with CCHa2R-RA neurons, four neurons with cell bodies in the SEZ and arbors in the flange and pars connected to the ISNs.…”

Section: Ccha2r-ra Neurons Regulate Water Ingestion Downstream Of Bitmentioning

confidence: 99%

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Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

González-Segarra

Pontes

Jourjine

et al. 2023

Preprint

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Consumption of food and water is tightly regulated by the nervous system to maintain internal nutrient homeostasis. Although generally considered independently, interactions between hunger and thirst drives are important to coordinate competing needs. InDrosophila, four neurons called the Interoceptive Subesophageal zone Neurons (ISNs) respond to intrinsic hunger and thirst signals to oppositely regulate sucrose and water ingestion. Here, we investigate the neural circuit downstream of the ISNs to examine how ingestion is regulated based on internal needs. Utilizing the recently available fly brain connectome, we find that the ISNs synapse with a novel cell type Bilateral T- shaped neuron (BiT) that projects to neuroendocrine centers.In vivoneural manipulations revealed that BiT oppositely regulates sugar and water ingestion. Neuroendocrine cells downstream of ISNs include several peptide-releasing and peptide-sensing neurons, including insulin producing cells (IPC), crustacean cardioactive peptide (CCAP) neurons, and CCHamide-2 receptor isoform RA (CCHa2R-RA) neurons. These neurons contribute differentially to ingestion of sugar and water, with IPCs and CCAP neurons oppositely regulating sugar and water ingestion, and CCHa2R-RA neurons modulating only water ingestion. Thus, the decision to consume sugar or water occurs via regulation of a broad peptidergic network that integrates internal signals of nutritional state to generate nutrient-specific ingestion.

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Section: Bit Downstream Partners Include Neuroendocrine Cells That Co...mentioning

confidence: 99%

Section: Ccha2r-ra Neurons Regulate Water Ingestion Downstream Of Bitmentioning

confidence: 99%

Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

González-Segarra

Pontes

Jourjine

et al. 2023

Preprint

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“…However, in 2010, the only aphid genomic model available to study aphid genetics and aphid-plant interactions was the pea aphid (Acyrthosiphon pisum) (Harris) (International Aphid Genomics Consortium, 2010). This was a milestone for aphid genomics, and the genome is still used 11 years later in a variety of genomic comparative studies (Biello et al, 2020;Li et al, 2019;Mathers et al, 2020;Shahid et al, 2021). Since the A. pisum genome, there are now 28 published genomes for 12 different aphid species, ranging from draft assemblies to chromosome-level assembly and annotation located on the BioInformatics Platform for Agroecosystem Arthropods (BIPAA) (BIPAA, 2021).…”

Section: Introductionmentioning

confidence: 99%

Genome assembly and transcriptomic analysis to elucidate the ability of Nasonovia ribisnigri to break host plant resistance

Garrett,

Teakle,

Collier

et al. 2024

Insect Molecular Biology

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Aphid genomic resources enable the study of complex life history traits and provide information on vector biology, host adaption and speciation. The currant–lettuce aphid (Nasonovia ribisnigri (Hemiptera: Aphididae) (Mosley)) is a cosmopolitan pest of outdoor lettuce (Lactuca sativa (Asterales: Asteraceae) (Linnaeus)). Until recently, the use of resistant cultivars was an effective method for managing N. ribisnigri. A resistant cultivar containing a single gene (Nr‐locus), introduced in the 1980s, conferred complete resistance to feeding. Overreliance of this Nr‐locus in lettuce resulted in N. ribisnigri's ability to break resistance mechanism, with first reports during 2003. Our work attempts to understand which candidate gene(s) are associated with this resistance‐breaking mechanism. We present two de novo draft assembles for N. ribisnigri genomes, corresponding to both avirulent (Nr‐locus susceptible) and virulent (Nr‐locus resistant) biotypes. Changes in gene expression of the two N. ribisnigri biotypes were investigated using transcriptomic analyses of RNA‐sequencing (RNA‐seq) data to understand the potential mechanisms of resistance to the Nr‐locus in lettuce. The draft genome assemblies were 94.2% and 91.4% complete for the avirulent and virulent biotypes, respectively. Out of the 18,872 differentially expressed genes, a single gene/locus was identified in N. ribisnigri that was shared between two resistant‐breaking biotypes. This locus was further explored and validated in Real‐Time Quantitative Reverse Transcription PCR (qRT‐PCR) experiments and has predicted localisations in both the cytoplasm and nucleus. This is the first study to provide evidence that a single gene/locus is likely responsible for the ability of N. ribisnigri to overcome the Nr‐locus resistance in the lettuce host.

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“…CCHa is enriched in the endocrine cells in the midgut ( Roller et al, 2008 ; Li et al, 2013 ; Veenstra and Ida, 2014 ; Hung et al, 2020 ; Titos and Rogulja, 2020 ; Zhu et al, 2022 ) or periphery adipose tissue ( Sano et al, 2015 ), suggestive of its role as a part of the enteroendocrine system. The CCHa system affects various physiological functions and related behaviors, including feeding, diuresis, reproduction, and metabolism ( Ida et al, 2012 ; Li et al, 2013 ; Veenstra and Ida, 2014 ; Ren et al, 2015 ; Sano et al, 2015 ; Fujiwara et al, 2018 ; Jayakumar et al, 2018 ; Capriotti et al, 2019 ; Jin et al, 2020 ; Titos and Rogulja, 2020 ; Shahid et al, 2021 ; Havula et al, 2022 ; Zhu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory

Yamagata

Imanishi²,

Wu³

et al. 2022

Front. Behav. Neurosci.

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CCHamide-2 (CCHa2) is a protostome excitatory peptide ortholog known for various arthropod species. In fruit flies, CCHa2 plays a crucial role in the endocrine system, allowing peripheral tissue to communicate with the central nervous system to ensure proper development and the maintenance of energy homeostasis. Since the formation of odor-sugar associative long-term memory (LTM) depends on the nutrient status in an animal, CCHa2 may play an essential role in linking memory and metabolic systems. Here we show that CCHa2 signals are important for consolidating appetitive memory by acting on the rewarding dopamine neurons. Genetic disruption of CCHa2 using mutant strains abolished appetitive LTM but not short-term memory (STM). A post-learning thermal suppression of CCHa2 expressing cells impaired LTM. In contrast, a post-learning thermal activation of CCHa2 cells stabilized STM induced by non-nutritious sugar into LTM. The receptor of CCHa2, CCHa2-R, was expressed in a subset of dopamine neurons that mediate reward for LTM. In accordance, the receptor expression in these dopamine neurons was required for LTM specifically. We thus concluded that CCHa2 conveys a sugar nutrient signal to the dopamine neurons for memory consolidation. Our finding establishes a direct interplay between brain reward and the putative endocrine system for long-term energy homeostasis.

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CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum

Cited by 16 publications

References 21 publications

Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

Genome assembly and transcriptomic analysis to elucidate the ability of Nasonovia ribisnigri to break host plant resistance

Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory

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