CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics

Abstract

A sparingly water-soluble gold(iii) complex was encapsulated in micelles functionalized with the CCK8-targeting moiety for the selective delivery of an anticancer drug.

Gold(III) Complexes in the Oncological Preclinical Arena: From Aminoderivatives to Peptidomimetics

“…7H) and targeted micelles ( Fig. 7G), respectively [55]. In fact, upon self-assembling, the second type of drug carrier is characterized by the presence of the octapeptide CCK8 (amino acid sequence: Asp 26 -Tyr 27 -Met 28 -Gly 29 -Trp 30 -Met 31 -Asp 32 -Phe 33amide whose properties are described below) bound to the external hydrophilic corona of the resulting micelles ( Fig.…”

“…7B) and Pluronic ® F127 (PF127, Fig. 7C) [54][55]. In both cases, the gold(III)dithiocarbamato complex AuL12 was selected as a model compound to be encapsulated due to its good antiproliferative rates recorded both in vitro and in vivo.…”

Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework

“…For the submission to Journal of Inorganic Biochemistry 5 supramolecular polymer [39] and lipophilic core of micelles produced from surfactant Pluronic® 127 [40]. In the recent decade some bioactive organic compounds incorporated in metal-organic frameworks (MOFs) have been reported [41][42][43], and we previously have reported the synergism of MOFs on the anti-cancer activity of a dinuclear gold(I) complex [44].…”

Therapeutic potential of dithiocarbamate supported gold compounds

“…Similarly, AuL12 was formulated with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N [amino(polyethylene glycol)-2000] (DSPEPEG2000) and Pluronic® F127 (PF127) micelles and both micelle systems were found to be suitable vehicles for AuL12. 45,46 Further addition of a bombesin peptide analogue or the octapeptide CCK8 to the micelle surface also gave the AuL12 nanomedicines cancer targeting properties, which lead to enhanced in vitro selective antiproliferative activity. 45,46 Recently, Massai and colleagues investigated this same dibromo [ethyl-N-(dithiocarboxy-kS,kS 0 )-N-methylglycinate] gold(III) (AuL12) as cysteine protease inhibitors.…”

“…45,46 Further addition of a bombesin peptide analogue or the octapeptide CCK8 to the micelle surface also gave the AuL12 nanomedicines cancer targeting properties, which lead to enhanced in vitro selective antiproliferative activity. 45,46 Recently, Massai and colleagues investigated this same dibromo [ethyl-N-(dithiocarboxy-kS,kS 0 )-N-methylglycinate] gold(III) (AuL12) as cysteine protease inhibitors. 47 The authors asserted that gold(III) dithiocarbamate (AuL12) triggered a dramatic inhibition of human cathepsins (B and L) and of L. mexicana cysteine protease CPB2.8DCTE at 20 mM.…”