CCL11, a novel mediator of inflammatory bone resorption

Kindstedt, Elin; Holm, Cecilia; Sulniute, Rima; Martinez-Carrasco, Irene; Lundmark, Richard; Lundberg, Pernilla

doi:10.1038/s41598-017-05654-w

Cited by 64 publications

(70 citation statements)

References 38 publications

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“…BMP‐2, BMP‐4, EGF, eotaxin, G‐CSF, IL‐1β, IL‐7, IL‐8, IL‐10, MIP‐1β, TNF‐α and TNF‐β were all significantly elevated in DDwoR patients compared to DDwR. These multi‐functional cytokines may stimulate bone and cartilage formation as a result of osteoblast activation, whilst others promote osteoclast activity, block chondrocyte function and contribute to tissue damage 22‐24 . Thus, the observed cytokine variations correspond to the tissue degeneration and/or remodelling discerned between these patient groups.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the observed cytokine variations correspond to the tissue degeneration and/or remodelling discerned between these patient groups. The majority of elevated cytokines were pro‐inflammatory, with chemotactic activity recruiting neutrophils, granulocytes and lymphoid cells to sites of inflammation 22‐28 . In particular, IL‐7, EGF and G‐CSF initiate tissue responses, to recruit and regulate hematopoietic stem cells from bone marrow to differentiate into inflammatory cells 29‐31 .…”

Section: Discussionmentioning

confidence: 99%

“…DDwoR‐SO was shown to have significantly higher concentrations of BMP‐4, eotaxin and IL‐8 compared to DDwoR‐DO. BMP‐4 promotes bone and chondral repair whilst eotaxin is upregulated during bone inflammation increasing osteoclast activity 23,24 . IL‐8, known as a potent chemokine, stimulates phagocytosis and potentially may be the regulator of inflammatory‐driven bone turnover, which requires increased numbers of scavenger cells 28 .…”

Section: Discussionmentioning

confidence: 99%

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Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Ulmner

Sugars

Naimi‐Akbar

et al. 2020

J of Oral Rehabilitation

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Background Symptomatic disc displacement (DD) of the temporomandibular joint (TMJ) may cause pain and limited mouth opening. The aetiopathogenesis is obscure and probably complex, which makes the diagnostic classification crude and mainly based on clinical criteria rather than disease mechanisms, and tissue characteristics. Objectives The study aim was to characterise and quantify synovial tissue in DD, where specific cytokine patterns might serve as potential biomarkers. Methods An observational cohort study was performed harvesting synovial tissue from 63 patients: 44 with DD without reduction (DDwoR) and 19 with DD with reduction (DDwR). DDwoR was subdivided depending on type of onset (sudden, n = 17; delayed, n = 27), and DDwR served as the control group. Proteins were extracted from tissue samples and investigated in a multi‐analytic profiling system. Results DDwoR patients had significantly higher concentrations in 12 out of 28 analysed cytokines compared to DDwR. In the same statistical model, significantly lower concentrations of interferon gamma‐induced protein (IP) 10, osteoprotegerin (OPG) and RANTES were detected in DDwoR patients. Women showed significantly higher concentrations of epidermal growth factor and interleukin (IL) 1ra compared to men. DDwoR with sudden onset had significant higher concentrations of bone morphogenetic protein 4, eotaxin and IL‐8 compared to DDwoR with delayed onset. Conclusions Characterising the biomarker panel for TMJ conditions may serve as suggestible targets for disease classification and novel treatment options. The significantly lower concentrations of IP‐10, OPG and RANTES could be proposed as putative markers for the separation of the studied conditions to other TMJ diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Ulmner

Sugars

Naimi‐Akbar

et al. 2020

J of Oral Rehabilitation

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“…Lower secretory levels of eotaxin-1 in Group III and IV compared to the control indicates that MSCs possess anti-inflammatory property. Increased secretion of eotaxin-1 is reported in chronic inflammatory lesions of the bone, including rheumatoid arthritis (Kokkonen et al, 2010), and is associated with osteoclast migration and bone resorption (Kindstedt et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an ex vivo Osteochondral Culture System

Jafri

Gauthaman

Abbas

et al. 2020

Front. Cell Dev. Biol.

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Osteoarthritis (OA) is a chronic degenerative joint disorder associated with degradation and decreased production of the extracellular matrix, eventually leading to cartilage destruction. Limited chondrocyte turnover, structural damage, and prevailing inflammatory milieu prevent efficient cartilage repair and restoration of joint function. In the present study, we evaluated the role of secreted cytokines, chemokines, and growth factors present in the culture supernatant obtained from an ex vivo osteochondral model of cartilage differentiation using cartilage pellets (CP), bone marrow stem cells (BM-MSCs), and/or BM-MSCs + CP. Multiplex cytokine analysis showed differential secretion of growth factors (G-CSF, GM-CSF, HGF, EGF, VEGF); chemokines (MCP-1, MIP1α, MIP1β, RANTES, Eotaxin, IP-10), pro-inflammatory cytokines (IL-1β, IL-2, IL-5, IL-6, IL-8, TNFα, IL-12, IL-15, IL-17) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) in the experimental groups compared to the control. In silico analyses of the role of stem cells and CP in relation to the expression of various molecules, canonical pathways and hierarchical cluster patterns were deduced using the Ingenuity Pathway Analysis (IPA) software (Qiagen, United States). The interactions of the cytokines, chemokines, and growth factors that are involved in the cartilage differentiation showed that stem cells, when used together with CP, bring about a favorable cell signaling that supports

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“…The other chemokines ligand CCL8 is known to recruits further neutrophils to the infarct to release MMPs and soluble IL-6 [25]. CCL11 bind CCR3 to stimulates the migration of immune cells like neutrophils [26] and was shown to recruit such cells to the heart and contribute to myocardial brosis [27].…”

Section: Discussionmentioning

confidence: 99%

C-C chemokine receptor type 5 links COVID-19, Rheumatoid arthritis, and Hydroxychloroquine: In silico analysis 

Hachim

Naeem³

et al. 2020

Preprint

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Patients with rheumatoid arthritis (RA) represent one of the fragile patient groups that might be susceptible to the critical form of the coronavirus disease -19 (COVID-19) . On the other side, RA patients have been found not to have an increased risk of COVID-19 infection. Moreover, some of the Disease-Modifying Anti-Rheumatic Drugs (DMARDS) commonly used to treat rheumatic diseases like Hydroxychloroquine (HCQ) were proposed as a potential therapy for COVID-19 with a lack of full understanding of their molecular mechanisms. This highlights the need for the discovery of common pathways that may link both diseases at the molecular side. In this research, we used the in silico approach to investigate the transcriptomic profile of RA synovium to identify shared molecular pathways with that of severe acute respiratory syndrome-corona virus-2 (SARS-COV-2) infected lung tissue. Our results showed upregulation of chemotactic factors, including CCL4, CCL8, and CCL11, that all shared CCR5 as their receptor, as a common derangement observed in both diseases; RA and COVID-19. Moreover, our results also highlighted a possible mechanism through which HCQ, which can be used as a monotherapy in mild RA or as one of the triple-DMARDs therapy (tDMARDs; methotrexate, sulphasalazine, and HCQ), might interfere with the COVID-19 infection. This might be achieved through the ability of HCQ to upregulate specific immune cell populations like activated natural killer (NK) cells, which were found to be significantly reduced in COVID-19 infection. In addition to its ability to block CCR5 rich immune cell recruitment that also was upregulated in the SARS-COV-2 infected lungs. This might explain some of the reports that showed beneficial effects.

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CCL11, a novel mediator of inflammatory bone resorption

Cited by 64 publications

References 38 publications

Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an ex vivo Osteochondral Culture System

C-C chemokine receptor type 5 links COVID-19, Rheumatoid arthritis, and Hydroxychloroquine: In silico analysis

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CCL11, a novel mediator of inflammatory bone resorption

Cited by 64 publications

References 38 publications

Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Synovial tissue cytokine profile in disc displacement of the temporomandibular joint

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an ex vivo Osteochondral Culture System

C-C chemokine receptor type 5 links COVID-19, Rheumatoid arthritis, and Hydroxychloroquine: In silico analysis&nbsp;

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C-C chemokine receptor type 5 links COVID-19, Rheumatoid arthritis, and Hydroxychloroquine: In silico analysis