CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis

Shen, Wenzhi; Zhang, Xiaoyuan; Tang, Jiaping; Zhang, Zhixin; Du, Renle; Luo, Dehong; Liu, Xiaoran; Xia, Yong; Li, Yanping; Wang, Shanshan; Yan, Siyuan; Yang, Wancai; Xiang, Rong; Luo, Na; Luo, Yunping; Li, Jianjun

doi:10.7150/thno.51000

Cited by 32 publications

(26 citation statements)

References 27 publications

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“…The promoter region of the CCL13 gene also has consensus sequences for the transcription factors NF-kB, AP-2 and glucocorticoid receptors (115). Furthermore, IL-10 treatment promotes expression of STAT3 phosphorylation, mediates STAT3 activation, which then binds to the CCL16 promoter gene and enhances its expression (50). There is no report about transcriptional regulation on PSMP, and further study is needed.…”

Section: Discussionmentioning

confidence: 99%

“…CCL16 is constitutively expressed by liver parenchymal cells and could also be expressed by monocytes treated with IL-10, IFN-g, and LPS (117,118). Shen et al demonstrated that IL-10 mediates STAT3 activation, which then binds to the CCL16 promoter gene and enhances its expression, thereby increasing cancer cell stemness (50). Mature human CCL16 protein contains 120 amino acids and shows 25%-31% identity to other human CC chemokines (CCL2, CCL7, CCL8, CCL13) (117,118) (Table 2).…”

Section: Ccl16 In Liver Diseasementioning

confidence: 99%

“…CCL16 can also trigger the angiogenic program in vascular endothelial cells through CCR1, which may play a role in tumorigenesis (122,123). CCL16 was upregulated in breast tumors and closely correlated with tumor progression (50,124). In addition, reports have shown that CCL16 can also mediate antitumor immunity by enhancing the effector and antigen-presenting cell (APC) function of macrophages and can augment T cell lytic activity by inducing the overexpression of TNF-a and Fas ligand (FasL) (125).…”

Section: Ccl16 In Liver Diseasementioning

confidence: 99%

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Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

et al. 2022

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Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.

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Section: Discussionmentioning

confidence: 99%

Section: Ccl16 In Liver Diseasementioning

confidence: 99%

Section: Ccl16 In Liver Diseasementioning

confidence: 99%

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Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

et al. 2022

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“…In our article 1 , there were misplaced images in Figure 7 E and Figure 8 D, respectively. The corrected version is provided here:…”

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confidence: 64%

CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis: Erratum

Shen¹,

Zhang²,

Tang³

et al. 2021

Theranostics

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“…According to the number and location of the highly conserved N‐terminal cysteines, chemokines are grouped into four different subfamilies: CC, CXC, CX3C, XC, and the nomenclature of the receptors is essentially similar to that of corresponding chemokines, that is, CC chemokine (CCL) binds to CC chemokine receptor (CCR) and CX3C ligand binds to CX3C receptor (CX3CR) (Table 1 ). 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 Depending on their functions in the body, chemokines are also categorized into proinflammatory c...…”

Section: Chemokine Systemsmentioning

confidence: 99%

Role of chemokine systems in cancer and inflammatory diseases

Zhao

2022

MedComm

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Chemokines are a large family of small secreted proteins that have fundamental roles in organ development, normal physiology, and immune responses upon binding to their corresponding receptors. The primary functions of chemokines are to coordinate and recruit immune cells to and from tissues and to participate in regulating interactions between immune cells. In addition to the generally recognized antimicrobial immunity, the chemokine/chemokine receptor axis also exerts a tumorigenic function in many different cancer models and is involved in the formation of immunosuppressive and protective tumor microenvironment (TME), making them potential prognostic markers for various hematologic and solid tumors. In fact, apart from its vital role in tumors, almost all inflammatory diseases involve chemokines and their receptors in one way or another. Modulating the expression of chemokines and/or their corresponding receptors on tumor cells or immune cells provides the basis for the exploitation of new drugs for clinical evaluation in the treatment of related diseases. Here, we summarize recent advances of chemokine systems in protumor and antitumor immune responses and discuss the prevailing understanding of how the chemokine system operates in inflammatory diseases. In this review, we also emphatically highlight the complexity of the chemokine system and explore its potential to guide the treatment of cancer and inflammatory diseases.

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CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis

Cited by 32 publications

References 27 publications

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis: Erratum

Role of chemokine systems in cancer and inflammatory diseases

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