CCL2/MCP-1 serum chemokine level in patients with odontogenic infectious and inflammatory diseases of the soft tissues of the maxillofacial area and mediastinum

Abstract

Aim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients' plasma CCL2/MCP-1 level was determined using a kit for specific ELISA. Results. The findings of the studies showed a statistically significant increase in the concentration of plasma CCL2/MCP-1 in patients of all study groups. Our study shows a significant increase in plasma CCL2/MCP-1 level in patients with odontogenic phlegmonas, abscesses and mediastinitis, compared to the group of healthy subjects. Conclusion. CCL2/MCP-1 may play an important role in the pathogenesis of odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum, which requires a careful follow-up study.

Retrospective Sensitivity Analysis of Kocuria Spp. To Antibiotics

“…Одонтогенні інфекційно-запальні захворювання становлять майже чверть випадків у структурі хірургічної патології [1,2]. При чому, доведено ключову роль у їх розвитку мікробного чинника [3].…”

“…Останні літературні дані вказують на зміни якісного складу мікробіоти вогнищ запалення при одонтогенних процесах зі зменшенням ролі представників роду Staphylococcus [3]. Це повʼязано як зі змінами у популяційному імунітеті останнім часом, так і диверсифікацією самих мікроорганізмів.…”

“…Cultivation for the final identification of microorganisms was carried out according to the standard method. Determining the sensitivity of selected representatives of genus Kocuria to antibiotics was conducted using the disk diffusion method (Kirby-Bauer) according to EUCAST recommendations (v.12.0;2022). In order to determine the groups of antibiotics to which Kocuria spp.…”