CCL23 in Balancing the Act of Endoplasmic Reticulum Stress and Antitumor Immunity in Hepatocellular Carcinoma

Karan, Dev

doi:10.3389/fonc.2021.727583

Cited by 10 publications

(10 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CCL24 which exhibits a high expression level in several types of cancer, this study found that it is underexpressed in breast cancer with no significant relation with OS. Again previous works have shown that a reduction in the chemokine CCL23 in hepatic tumours is linked to a poor prognosis for HCC patients and may be a strategy used by the tumour cells to avoid the immune system [37]. The current study also confirms these results evident from the expression profile and Survival analysis.…”

Section: Discussionsupporting

confidence: 89%

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer

Guha

2024

Preprint

View full text Add to dashboard Cite

Background: Cancer is a genetic disease, where gene alterations play a significant role in the disease onset and pathogenesis. Analysis of the underlying gene interaction pathways could reveal new biomarkers and could also potentially help in the development of targeted drugs for therapeutics. Microarray techniques have emerged as powerful tools capable of simultaneously measuring the expression levels of thousands of genes, making them invaluable in cancer biology research. However, the processing of the resultant datasets poses significant challenges due to their high dimensionality. Also, feature extraction becomes essential to discern the crucial features within these extensive datasets. To mitigate these difficulties advanced computational techniques like Machine Learning (ML) could be instrumental. LASSO- regression-based classification is an advanced ML technique that can help in feature selection by evaluating individual parameters like genes. Methods: This study focuses on uncovering key prognostic genes for breast cancer using a combination of LASSO regression-based classifier and statistical bioinformatics models. Differentially expressed genes (DEGs) were identified using the "Limma" package in R, and significant genes were further filtered using the LASSO-based classifier significance coefficient. Genes common to both methods were considered as the focus of this study. Additionally, Protein-Protein Interaction (PPI) networks of these key genes were constructed using STRING, and hub genes, significant modules, and associated genes were identified using Cytoscape. Results: This study identified CCR8, CXCL11, CCL23, CCL24, CCL28, and CCL21 as signature prognostic genes for breast cancer, revealing a strong association between chemokines and breast cancer pathogenesis. Extensive literature searches were conducted to validate and confirm their prognostic significance in the disease. Conclusion: These findings are pivotal for enhancing our comprehension of the pathways involved in breast cancer. Additionally, they hold promise as novel biomarkers for diagnostic purposes and may also reveal significant therapeutic targets for the management of breast cancer.

show abstract

Section: Discussionsupporting

confidence: 89%

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer

Guha

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Previously, we hypothesized that CCL23 might be a stress-related chemokine and an elevated CCL23 may help promote antitumor immunity. 36 Indeed, overexpression of CCL23 is associated with liver cancer suppression, 37 and an elevated serum level of CCL23 was linked with reduced risk factors in gastric cancer. 38 However, CCL23 is a relatively lesser characterized chemokine whose role in cancer suppression remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…CCL23, also known as macrophage inflammatory protein‐3, was the only observed chemokine showing race‐ and cancer‐specific differences with significantly high serum levels of CCL23 in CA men than AA, whereas CCL23 was significantly low in cases with respective races. Previously, we hypothesized that CCL23 might be a stress‐related chemokine and an elevated CCL23 may help promote antitumor immunity 36 . Indeed, overexpression of CCL23 is associated with liver cancer suppression, 37 and an elevated serum level of CCL23 was linked with reduced risk factors in gastric cancer 38 .…”

Section: Discussionmentioning

confidence: 99%

Racial differences in serum chemokines in prostate cancer patients

Karan,

Wick,

Dubey

et al. 2023

Cancer

Self Cite

View full text Add to dashboard Cite

BackgroundThis study aimed to understand the differential levels of inflammatory chemokines in association with higher prostate cancer incidence and mortality in African American (AA) men than in Caucasians (CA).MethodsThe authors used a chemokine assay to simultaneously measure 40 chemokines and cytokines levels in the serum of preoperative prostate cancer patients and healthy controls of AA and CA races. Selected chemokines (CXCL2, CXCL5, and CCL23) serum level was validated in 211 serum samples from prostate cancer patients and healthy controls. Differential expression of CXCL5 and CCL23 was analyzed using immunohistochemistry in a representative cohort of prostate tumor tissues of AA and CA races.ResultsRace‐specific comparisons from 211 serum samples showed significantly higher levels of CXCL2 (control: 3104.0 pg/mL vs. cancer: 2451.0 pg/mL) and CXCL5 (control: 5189.0 pg/mL vs. cancer: 5459.0 pg/mL) in AA men than in CAs (CXCL2; control: 1155.0 pg/mL vs. cancer: 889.3 pg/mL, and CXCL5; control: 1183.0 pg/mL vs. cancer: 977.5 pg/mL). CCL23 differed significantly within and between the races with a lower level in AA cancer cases (454.5 vs. 966.6 pg/mL) than healthy controls (740.5 vs. 1263.0 pg/mL). Patient age, prostate‐specific antigen, or Gleason scores were not significantly associated with these chemokines. Immunostaining for CXCL5 and CCL23 in a representative cohort of archival prostate tissues displayed significantly higher CXCL5 in prostate tumors than in adjacent benign tissues, whereas CCL23 was nondetectable in most of the analyzed tumor tissues.ConclusionLower levels of CCL23 in AA prostate cancer patient sera and tumor tissues and high CXCL2 and CXCL5 may contribute to aggressive prostate cancer, as often seen in AA men. The disproportionate levels of serum chemokines associated with race warrant further exploration to improve equitability in precision oncology to benefit prostate cancer patients.

show abstract

“…To find the association between the CSF proteins and autistic traits in twins diagnosed with ASD and other neurodevelopmental disorders, a study measured 203 proteins in cerebrospinal fluid (n=86, ASD=19, neurotypical=41). The autistic traits correlated significantly with four CSF proteins (Smedler et al, 2021): C-C motif chemokine ligand 23 (CCL23) – a chemokine active on immune cells like T lymphocytes and monocytes (Karan, 2021). Agouti-related protein (AGRP) – synthesized in hypothalamic neurons that are involved in energy metabolism and appetite. Chitinase-3-like protein 1 (CHI3L1) – protein marker of inflammation. Lipopolysaccharide-induced TNF-α factor (LITAF). CCL23, AGRP, CHI3L1 correlated negatively, and LITAF correlated positively with autistic traits.…”

Section: Methodsmentioning

confidence: 99%

“…1. C-C motif chemokine ligand 23 (CCL23) -a chemokine active on immune cells like T lymphocytes and monocytes (Karan, 2021).…”

Section: Presence Of Neuroinflammation Markers In Csfmentioning

confidence: 99%

Characteristics of Cerebrospinal Fluid in Autism Spectrum Disorder - A Systematic Review

Srivastava,

O’Reilly

2024

Preprint

View full text Add to dashboard Cite

Autism Spectrum Disorder (ASD) is a range of neurodevelopmental conditions characterized by impaired social interaction, learning, and restricted or repetitive behaviors. The underlying causes of ASD are still debated, but researchers have found many physiological traits to help understand the etiology of ASD.Some of the features that characterize people with ASD are immune markers (e.g. increased lymphocytes, cytokine levels), decreased neuropeptides like oxytocin and arginine vasopressin, folate deficiency, change in brain anatomy and physiology, and increased extra axial cerebrospinal fluid (CSF). CSF has a critical role in maintaining the homeostasis of the neuronal environment and has, therefore, been analyzed in multiple conditions that impact the central nervous system. The study of CSF is critical in understanding neurological disorders as its composition changes with the disorders, and these changes may indicate various disorder-related physiological mechanisms. For this systematic review, we searched the PubMed database for studies published between 1977 and 2023. We found 54 studies from 276 eligible for this review after manual screening. We took stock of the evidence supporting the hypothesis that ASD alters the properties and composition of CSF. We systematically report on the different attributes of CSF in the ASD population that could 1) be potential biomarkers, 2) assist in understanding the origins and progression of ASD, and 3) shed light on the aspects of the relationship between ASD and the immune system.

show abstract

CCL23 in Balancing the Act of Endoplasmic Reticulum Stress and Antitumor Immunity in Hepatocellular Carcinoma

Cited by 10 publications

References 75 publications

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer

Racial differences in serum chemokines in prostate cancer patients

Characteristics of Cerebrospinal Fluid in Autism Spectrum Disorder - A Systematic Review

Contact Info

Product

Resources

About