CCR10 activation stimulates the invasion and migration of breast cancer cells through the ERK1/2/MMP-7 signaling pathway

Lin, Hui‐Yi; Sun, Shuming; Lu, Xiaofeng; Chen, Pingying; Chen, Chunfa; Liang, Weiquan; Peng, Chunyan

doi:10.1016/j.intimp.2017.07.018

Cited by 36 publications

(21 citation statements)

References 19 publications

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“…18 These results are consistent with the fact that some other chemokine receptors, such as CXCR4, CCR7, and CCR10, also are involved in tumor invasion. [22][23][24][25][26] Furthermore, the present findings highlight the pivotal role of CCR4 in tumor progression at a relatively early stage of oral cancer development compared with lymph node metastasis. Cell invasion is the first step of cancer metastasis that has dramatic effects on the survival of patients with cancer.…”

Section: Discussionsupporting

confidence: 55%

CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

Wang

Zhang

Zhu³

et al. 2019

Journal of Oral and Maxillofacial Surgery

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Chemokine receptors are involved in tumor metastasis and can predict poor prognosis; however, the expression and clinicopathologic relevance of chemokine receptors in early-stage cancer remain largely unknown. This study measured the association between chemokine (C-C motif) receptor-4 (CCR4) expression and prognosis in patients with histologically node-negative (pN0) oral tongue cancer. Materials and Methods: A retrospective analysis of CCR4 expression data from a consecutive case series of patients with pN0 oral cancer tongue was conducted. The expression of CCR4 by immunohistochemistry was investigated and the association between CCR4 expression and clinicopathologic variables and overall and disease-free survivals was evaluated using Kaplan-Meier analysis and a Cox regression model. Results: CCR4 expression was examined in 128 human tongue cancerous samples (109 tongue squamous cell carcinomas [TSCCs] and 19 other types) and 10 normal tongue samples and was found to be highly expressed in tumor tissues compared with normal tissues. CCR4 expression was observed in 64.2% of patients with TSCC and showed a significant association with tumor stage (P = .037). Patients with CCR4-positive expression exhibited poorer overall and disease-free survivals compared with those with CCR4-negative expression (P < .001 and P = .001), and CCR4-positive expression was an independent factor of unfavorable overall and disease-free survivals (P = .002 and P = .007). Conclusions: This study identified CCR4 as a potential prognostic biomarker for recurrence and survival of patients with pN0 oral tongue cancer. Thus, CCR4 might be a possible therapeutic target for patients with early-stage cancer.

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Section: Discussionsupporting

confidence: 55%

CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

Wang

Zhang

Zhu³

et al. 2019

Journal of Oral and Maxillofacial Surgery

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“…E ). CCL27 (alias CTACK), which is a positive regulator of breast cancer aggressiveness, was the most expressed cytokine. Among the well‐expressed cytokines, there were some factors known to foster osteoclastogenesis, including IL8, Macrophage Inflammatory Protein (MIP)‐1α (alias CCL3) and MIP‐1β (alias CCL4), and Platelet‐Derived Growth Factor (PDGF)‐BB, whereas, among the angiogenic cytokines, we observed Angiopoietin 2 and VEGF.…”

Section: Resultsmentioning

confidence: 99%

Extracellular Vesicles From Osteotropic Breast Cancer Cells Affect Bone Resident Cells

Loftus

Cappariello

George

et al. 2019

Journal of Bone and Mineral Research

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Extracellular vesicles (EVs) are emerging as mediators of a range of pathological processes, including cancer. However, their role in bone metastases has been poorly explored. We investigated EV-mediated effects of osteotropic breast cancer cells (MDA-MB-231) on bone resident cells and endothelial cells. Pretreatment of osteoblasts with conditioned medium (CM) of MDA-MB-231 (MDA) cells promoted pro-osteoclastogenic and pro-angiogenic effects by osteoblast EVs (OB-EVs), as well as an increase of RANKL-positive OB-EVs. Moreover, when treating osteoblasts with MDA-EVs, we observed a reduction of their number, metabolic activity, and alkaline phosphatase (Alp) activity. MDA-EVs also reduced transcription of Cyclin D1 and of the osteoblast-differentiating genes, while enhancing the expression of the pro-osteoclastogenic factors Rankl, Lcn2, Il1b, and Il6. Interestingly, a cytokine array on CM from osteoblasts treated with MDA-EVs showed an increase of the cytokines CCL3, CXCL2, Reg3G, and VEGF, while OPG and WISP1 were downregulated. MDA-EVs contained mRNAs of genes involved in bone metabolism, as well as cytokines, including PDGF-BB, CCL3, CCL27, VEGF, and Angiopoietin 2. In line with this profile, MDA-EVs increased osteoclastogenesis and in vivo angiogenesis. Finally, intraperitoneal injection of MDA-EVs in mice revealed their ability to reach the bone microenvironment and be integrated by osteoblasts and osteoclasts. In conclusion, we showed a role for osteoblast-derived EVs and tumor cell-derived EVs in the deregulation of bone and endothelial cell physiology, thus fueling the vicious cycle induced by bone tumors.n 396 LOFTUS ET AL. Osteoblast primary culturesCalvariae from 7-day-old WT CD1 mice were explanted, cleaned free of soft tissues, and digested three times with 1 mg/mL Clostridium histolyticum type IV collagenase and 0.25% trypsin, for 20 min at 37 C, with gentle agitation. Cells from the second and third digestions were plated following centrifugation at 200g for 7 min and grown in DMEM plus 10% FBS. At confluence, cells were trypsinized and plated according to the experimental protocol. The purity of the culture was evaluated by the transcriptional expression of the osteoblast markers alkaline phosphatase (Alp), Runt-related transcription factor 2 (Runx2), type I collagen, and osteocalcin and by the cytochemical evaluation of Alp activity. (14) Journal of Bone and Mineral Research BREAST CANCER CELL EVS AFFECT BONE RESIDENT CELLS 397 n Journal of Bone and Mineral Research n 398 LOFTUS ET AL.

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“…In hepatocellular carcinoma, CCL28 increases the migration of these cells [ 327 ]. The same activation of CCR10 by both the ligands causes the migration of breast cancer cells [ 325 , 328 ] and glioblastoma multiforme cells [ 324 ]. After entering the bloodstream, a cancer cell is trapped in organs and tissues, which have a high expression of chemokines for the receptors on the cancer cell.…”

Section: Ccr10 Ccl28 and Ccl27mentioning

confidence: 99%

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

Korbecki

Grochans

Gutowska

et al. 2020

IJMS

240

176

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CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic cells, eosinophils, macrophages, monocytes, and NK cells, as well in neoplasia. In this review, we discuss human CC motif chemokine ligands: CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, and CCL28 (CC motif chemokine receptor CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands). We present their functioning in human physiology and in neoplasia, including their role in the proliferation, apoptosis resistance, drug resistance, migration, and invasion of cancer cells. We discuss the significance of chemokine receptors in organ-specific metastasis, as well as the influence of each chemokine on the recruitment of various cells to the tumor niche, such as cancer-associated fibroblasts (CAF), Kupffer cells, myeloid-derived suppressor cells (MDSC), osteoclasts, tumor-associated macrophages (TAM), tumor-infiltrating lymphocytes (TIL), and regulatory T cells (Treg). Finally, we show how the effect of the chemokines on vascular endothelial cells and lymphatic endothelial cells leads to angiogenesis and lymphangiogenesis.

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CCR10 activation stimulates the invasion and migration of breast cancer cells through the ERK1/2/MMP-7 signaling pathway

Cited by 36 publications

References 19 publications

CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

Extracellular Vesicles From Osteotropic Breast Cancer Cells Affect Bone Resident Cells

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

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