CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors

Abstract

This study provides the first evidence for an association between CCR5 promoter polymorphisms and long-term asymptomatic HIV-1 infection, with individuals lacking the CCR5 59029A/CCR5 59353C homozygous genotype likely to progress more slowly towards AIDS and/or death.

Type 1 Chemokine Receptor Expression in Chagas' Disease Correlates with Morbidity in Cardiac Patients

“…It is possible that a smaller number of type 1 cells into the inflamed cardiac tissue, due to a decrease in CCR5 membrane expression, protects against the development of severe chagasic myocardiopathy. Similar data have been previously reported in genetic associations of CCR5 variants and development of AIDS in human immunodeficiency virus type 1-infected individuals (8,21).…”

Human Genetic Factors and Respiratory Syncytial Virus Disease Severity

“…Therefore, variations in CCR5, CCL5, or CCL3 may play a role in the immunopathology of RSV infections. Several promoter region variants of the CCR5 gene that have been described are associated with several diseases such as chagasic cardiomyopathy (16) and reduced progression to AIDS after infection with HIV, although this may not be functionally relevant to RSV since CCR5 is a coreceptor for HIV but is not thought to be a cellular receptor for RSV (20). Case-control and family-based association studies show that a Ϫ2459G variant and a 2554T polymorphism of CCR5 are associated with severe bronchiolitis (61).…”

CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro

“…The common polymorphism of the CCR5 promoter -2459 is also assoociated with delayed progression to AIDS in HIV-1 infected homosexual men [11]; HIV-1-infected persons with the CCR5 -2459 G/G polymorphism had slower progression to AIDS than those who had the A/A promoter variant [11][12][13]. Interestingly, constructs with the G promoter polymorphism had less promoter activity than did constructs with the A-polymorphism when linked to a cholamphenical acetyltransferase (CAT) reporter gene [11].…”