CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype
JianFei Wang,
Binle Tian,
Zhilong Wang
et al.
Abstract:Regulatory T cells (Tregs) are main immunosuppressive cells in tumor immune microenvironment (TIME). However, systemic Treg depletion is not favored due to the crucial role of Tregs in the maintenance of immune homeostasis and prevention of autoimmunity. Recently, CCR8 has been identified as a key chemokine receptor expressed on tumor-infiltrating Tregs and targeted blockade exerts anticancer effect in several cancers, but whether this pathway is involved in the progression of hepatocellular carcinoma (HCC) re… Show more
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