CCXXVII.—The interaction of iodine and thiocarbamide. The properties of formamidine disulphide and its salts

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

“…Therefore, while the studies above showed clearly the OH scavenging activity of DMTU when OH was generated directly (without O2 or H202 precursors) from radiation, it is important to consider the possibility that, in the PMN, 'OH production could also be decreased by scavenging of H202 by DMTU. Earlier reports of reaction of thiourea with H202 supported this possibility (34).…”

Oxidation of thiourea and substituted thioureas: a review

“…Thiourea, which is the simplest and one of the most reactive sulfur compounds, can be oxidized by a wide variety of oxidizing agents (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). The reaction pathways and the final products of the oxidation reaction depend on the reagents used and condition of the reaction mixtures.…”

“…However, under acidic conditions, with excess of sodium peroxydisulfate or hydrogen peroxide, the oxidation of thiourea led to the formation of NH + 4 , sulfur, SO 2− 4 , and CO 2 (31). But in excess thiourea, the formamidine disulfide was formed at low pH, and thiourea dioxide was produced under neutral conditions (1,31,32 Some aroylthioureas exhibited abnormal oxidative behavior during their reactions with 2,3-diphenylcyclopropenone resulting in (E/Z)-3-(aroylthioureido)-2-phenylcinnamic acids (43). The unusual reaction was due to the nucleophilic addition of N followed by hydrolysis, ring opening, and oxidation processes (Scheme 4 Sahu et al (44) reported the formation of aryl isocyanide from the oxidation of arylthiourea by cetyltrimethylammonium dichromate (CTADC) in organic solvent leading to arylurea and isonitrile in different reaction conditions.…”

Differentiation of the Antithyroid Action of Thiouracil, Thiourea and Paba From Sulfonamides by Iodide Administration

“…Many investigators (Baumann, Metzger, and Marine, 1944;Keston, 19^4;Campbell, Landgrebe, and Morgan, 1944;Miller, Roblin, and Astwood, 1945;Calvo and Goemine, 1946) have associated the well known reduction of iodine to iodide by sulfhydryl compounds, shown specifically for thiourea by Werner (1912), and for thiouracil by Miller, Roblin, and Astwood (1945), with antithyroid activity. According to Li (1942) and Harrington (1944) iodide must be oxidized to effect the iodination of tyrosine.…”

“…Thiourea is a strong reducing agent, a resonating sulfhydryl compound, and consequently it readily reduces iodine to iodide, a reaction studied in detail by Werner (1912). It seemed possible therefore that the antithyroid action of thiourea might be due to the prevention of the formation of appreciable amounts of iodine in the thyroid gland.…”