CD-30(Ki-1)–Positive Anaplastic Large Cell Lymphoma in a Pleural Effusion

Das, Dilip K.; Chowdhury, Veena; Kishore, Bimal; Chachra, Krishanlal; Bhatt, Naveen C.; Kakar, Atul

doi:10.1159/000331109

Cited by 19 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other subtypes of HLNs reported in literature include: Anaplastic large-cell lymphoma, with intermediate to large cells with irregular nuclei, RS-like cells, and cells with wreath-like arrangement of nuclei. [ 13 ] Marginal zone lymphoma (MZL) shows small- to intermediate-sized cells with round nuclei. Plasmacytoid differentiation and emperipolesis are peculiar features described in MZL.…”

Section: Discussionmentioning

confidence: 99%

Hematolymphoid neoplasms in effusion cytology

2018

View full text Add to dashboard Cite

Background:Hematolymphoid neoplasms (HLNs) presenting as body cavity effusions are not a common finding. They may be the first manifestation of the disease. A diagnosis on effusion cytology may provide an early breakthrough for effective clinical management.Aims:Study the cytomorphology of HLNs in effusion cytology, determine common types, sites involved and uncover useful cytomorphologic clues to subclassify them.Materials and Methods:Twenty-four biopsy-proven HLN cases with malignant body cavity effusions and 8 cases suspicious for HLN on cytology but negative on biopsy are included in this study. Effusion cytology smears were reviewed for cytomorphological features: cellularity, cell size, nuclear features, accompanying cells, karyorrhexis, and mitoses.Results:Diffuse large B-cell lymphoma (37%) was the most common lymphoma type presenting as effusion followed by peripheral T-cell lymphoma (25%). Pleural effusion (75%) was most frequent presentation followed by peritoneal effusion (20.8%). Pericardial effusion was rare (4.1%). The common cytologic features of HLNs in effusions: high cellularity, lymphoid looking cells with nuclear enlargement, dyscohesive nature, and accompanying small lymphocytes. Mitosis and karyorrhexis were higher in high-grade HLNs when compared to low-grade HLNs. Myelomatous effusion showed plasmacytoid cells. Very large, blastoid looking cells with folded nuclei, high N: C ratio, and prominent nucleoli were seen in leukemic effusion.Conclusion:HLNs have characteristic cytomorphology and an attempt to subclassify them should be made on effusion cytology. Reactive lymphocyte-rich effusions cannot be distinguished from low-grade lymphomas based on cytomorphology alone. Ancillary tests such as immunocytochemistry, flow cytometry, and/or molecular techniques may prove more useful in this regard.

show abstract

Section: Discussionmentioning

confidence: 99%

Hematolymphoid neoplasms in effusion cytology

2018

View full text Add to dashboard Cite

show abstract

Pleural fluid cytology of Hodgkin's disease: Cytomorphologic features and the value of immunohistochemical studies

Olson¹,

Silverman²,

Powers³

2000

Diagn. Cytopathol.

View full text Add to dashboard Cite

Two cases in which Hodgkin's disease (HD) was cytologically diagnosed in pleural effusions are presented. The presence of Reed‐Sternberg (R‐S) cells was confirmed by positive staining for both CD15 and CD30, and negative staining for leukocyte common antigen. In addition, the differential diagnosis of HD in effusion cytology is presented, including look‐alikes of R‐S cells that can potentially lead to an incorrect diagnosis. To the best of our knowledge, we believe this is only the second cytologic report of HD diagnosed in a pleural effusion using immunohistochemistry to confirm the diagnosis. Diagn. Cytopathol. 2000;22:21–24. © 2000 Wiley‐Liss, Inc.

show abstract

Lymph nodes

2017

Cytopathology of the Head and Neck

View full text Add to dashboard Cite

CD-30(Ki-1)–Positive Anaplastic Large Cell Lymphoma in a Pleural Effusion

Cited by 19 publications

References 15 publications

Hematolymphoid neoplasms in effusion cytology

Hematolymphoid neoplasms in effusion cytology

Pleural fluid cytology of Hodgkin's disease: Cytomorphologic features and the value of immunohistochemical studies

Lymph nodes

Contact Info

Product

Resources

About