CD10 AND CD34 EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA IN MOROCCO: Clinical Relevance and Outcome

Abstract

CD10 and CD34 expression in 86 Moroccan children with acute lymphoblastic leukemias (ALL) and the relevance to prognosis, diagnosis, and outcome during a 5-year follow-up were examined. At diagnosis, 57% of patients had CD10(+) blasts, while 35% had CD34(+) blasts. The CD10(+) blast frequency was much higher (80%) in B-ALL than in T-ALL (20%). The frequency of CD34(+) blasts was higher in B-ALL (48%) compared to T-ALL (16%). The 5-year survival curves showed that children with CD10(+) B-ALL had a significantly longer survival rate than those with CD10(-), as observed for T-ALL. The survival rate of B-ALL expressing CD34 was higher than that of CD34(-). Thus, CD34 and CD10 expression may have prognostic value and is associated with a better clinical outcome.

Detection of CD10, CD34 and their combined expression on Childhood Acute Lymphoblastic Leukemia and the association with clinical outcome in Indonesia

“…A study conducted by Dakka et al, found that the five years survival rate for the CD10 − CD34 − group was only 22% [10]. In our study, lack of both CD10 and CD34 expression was also related to worse prognosis; OS was 61% in the combination CD10 + and/or CD34 + group vs. 31% in the double negative group, p<0.001 ( Figure 1C).…”

“…Studies on the expression of CD10 and CD34, alone or in combination, as a prognostic factor, found discrepancies [6,7,10,10,22,23]. These discrepancies may be dependent upon sensitivity of the immunophenotyping, upon patient variables, or upon differences in treatment protocols.…”

“…Dakka, et al 2009, found that in B-lineage ALL, a combination of CD10 + CD34 + coexpression was found in 44% of cases, while CD10 + CD34 -was found in 34%. In T-lineage ALL, CD10 -CD34 -was found in the majority (76%) and was associated with worse prognosis with a 5 years survival rate of 22% [10].…”

“…Dakka, et al 2009, found that in B-lineage ALL, a combination of CD10 + CD34 + coexpression was found in 44% of cases, while CD10 + CD34 -was found in 34%. In T-lineage ALL, CD10 -CD34 -was found in the majority (76%) and was associated with worse prognosis with a 5 years survival rate of 22% [10]. To elucidate the relevance of the combined CD10 and CD34 expression as independent prognostic factor in children with ALL in Yogyakarta we related the expression of CD10, CD34 and the combination of both markers to clinical characteristics as well as to outcome.…”

“…[1][2][3][4][5] CD10 and CD34 are surface markers that have been reported to have prognostic relevance in childhood acute lymphoblastic leukemia (ALL), but the results were conflicting [6][7][8][9][10].…”