CD10 expression in gastric carcinoma is correlated with tumor grade and survival

Jafarian, Amir Hossein; Forooshani, Melika Kooshki; Takallou, Leila; Roshan, Nema Mohamadian

doi:10.18051/univmed.2019.v38.41-47

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…In a similar study by Forooshani MK et al a statistically significant correlation was detected between tumor stage and CD10 expression. 11 This suggests that CD10 expression by stromal cells may play an important role in the pathogenesis of gastric cancer and also that the proliferation of CD10-positive stromal cells is part of the mechanism of invasion in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

CD10 expression in gastric adenocarcinoma and its correlation with histopathological features and lymph node metastasis

Mohan

Krishnan

2021

Asian J Med Sci

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Background: Gastric cancer is one of the most common cancers worldwide. Invasion and metastasis are known prognostic factors. Previous studies have suggested CD10 expression in the epithelium and stroma of various carcinomas is associated with more aggressive behavior of the tumor. Aims and Objective: To study the immunohistochemical expression of CD10 in stromal cells of gastric adenocarcinoma and to correlate the expression with various clinicopathological features and lymph node metastasis. Materials and Methods: A cross sectional study of CD10 expression in 40 cases of gastric carcinoma in gastrectomy specimens was done. CD10 expression was correlated with age, gender, tumor site, tumor grade, histologic sub type, depth of invasion and lymph node status. Results: Out of 40 cases, 72.5% were males and 27.5% were females. Majority of cases were seen in 6th and 7th decades. Antrum was the most common location (70%) and intestinal morphology was the commonest histologic subtype (47.5%). Tumor size ranged from 2.5 to 11cms. 40% tumors were well differentiated. Majority (62.5%) of the tumors were in T3 stage. 25 (62.5%) cases showed a positive CD10 expression in stromal cells. Stromal CD10 expression in gastric carcinoma did not correlate with the age and gender of the cases as well as the location and size of the tumor, histologic subtype and lymph node involvement but correlated with depth of invasion (T stage) (p <0.05). Conclusion: CD10 expression in gastric adenocarcinoma shows a significant correlation with depth of invasion. CD10 may be used as an immunohistochemical surrogate of tumor behavior.

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Section: Discussionmentioning

confidence: 99%

CD10 expression in gastric adenocarcinoma and its correlation with histopathological features and lymph node metastasis

Mohan

Krishnan

2021

Asian J Med Sci

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“…Esophageal cancer is rarely observed in people under the age of 30, and the mean age of patients when the disease appears is 60 years. The condition is 2-4 times more frequent in males than in females (3).…”

Section: Introductionmentioning

confidence: 93%

“…Therefore, surgical success depends on the early diagnose of this cancer. The patients having the most prolonged survival are those who can be operated (3). It is also important to determine the tumor grade accurately for the treatment plan and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Analysis of Complications and Causes of Mortality in Patients Undergoing Esophagectomy for Esophageal Cancer

Ağca

Topal

Parsak

et al. 2021

ircmj

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Background: Esophageal cancer is the eighth most common cancer and the sixth most common cause of death from cancer. Esophagectomy is still the essential treatment for esophageal cancer despite its high morbidity rate. The prediction of complications that are likely to appear after surgery can be the most critical factor in reducing morbidity. Objective: The present study aimed to examine the postoperative complications and causes of mortality in patients undergoing esophagectomy for esophageal cancer. Material and Methods: Data from 34 patients with esophageal adenocarcinoma or squamous cell carcinoma undergoing esophagectomy in the general surgery clinic of Çukurova University Medical School Hospital were collected and analyzed retrospectively between January 1, 2011, and January 1, 2020. Postoperative complications were identified according to the Clavien-Dindo classification (CD). The patients were assigned into two groups (Group 1 and Group 2). Group 1 and Group 2 included patients with CD grade <3 and CD grade , respectively. Results: The mean±SD age of patients (n=34) undergoing resection for esophageal cancer was obtained at 56.38±11.00 years. The ratio of female to male patients was equal. The most common accompanying disease was diabetes mellitus. The number of patients with the American Society of Anesthesiologists score 3 was higher in Group 2 (P=0.034). The tumor was most frequently located in the lower thoracic esophagus of patients in Group 1 and Group 2, and the rate of cervical anastomosis was higher in Group 2. The rate of manual anastomosis was higher in both groups. Respiratory complications were the most frequent complication in both groups; however, a higher rate of respiratory complications was observed in Group 2 (P=0.038). The postoperative 30-days mortality and the reoperation rate were higher in Group 2. Conclusion: Radical surgery for esophageal cancer results in a high rate of complications and death due to the location of the tumor and diagnosis at the advanced stage. Complications and mortality may result from patient-related factors and the surgical technique. The diagnosis and treatment of the correctable causes before surgery can enhance the chance of survival and the quality of life in patients.

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“…Colorectal cancer (CRC) is one of the most common causes of malignant tumor-related deaths in the world (1), and it is the most common malignancy of the digestive system. There are more than 1.2 million new cases and no less than 600,000 deaths of CRC every year, and they both show increasing trends year by year (2).…”

Section: Introductionmentioning

confidence: 99%

Research on Associations of MiR-149 with Nutritional Risk Assessment and Postoperative Complications of Patients with Colorectal Cancer

2021

ircmj

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Background: MiRNAs play an important role in the development of colorectal cancer, however, there’s few evidence of miRNAs in the screening of nutritional risks of patients with colorectal cancer. Objectives: To explore the role of preoperative miR-149 in nutritional screening of patients with CRC, and its associations with clinicopathological characteristics and postoperative complications of patients with CRC. Methods: The associations of serum miR-149 with clinicopathological characteristics and postoperative complications of patients were analyzed. The ROC curves were plotted with miR-149 as the test variable, and the grouping results of patients with nutritional risks [total NRS2002 score ≥3 points] and no nutritional risks (total NRS2002 score <3 points) based on the preoperative NRS2002 score as the state variables. The consistency of miR-149 and NRS2002 in nutritional screening of CRC was analyzed using Kappa test. Results: MiR-149 was low in patients with CRC. There was a statistically significant difference in the miR-149 expression among patients with different tumor diameters and TNM stages in the two groups. The preoperative total NRS2002 score of CRC patients was <3 points (without nutritional risks) in 271 cases, and ≥3 points (with nutritional risks) in 129 cases. The sensitivity and specificity of miR-149 in the diagnosis of nutritional risks were 76.74% and 84.50%. The Kappa value was 0.622 with miR-149 =3.095 as the critical value. Conclusions: MiR-149 can reflect the perioperative nutritional status of patients with CRC, and miR-149 =3.095 can be used as the cut-off point for nutritional risk screening of patients with CRC, which is an important index for assessing the nutritional risk in the perioperative period. The expression of miR-149 has a certain association with postoperative complications.

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CD10 expression in gastric carcinoma is correlated with tumor grade and survival

Cited by 4 publications

References 19 publications

CD10 expression in gastric adenocarcinoma and its correlation with histopathological features and lymph node metastasis

CD10 expression in gastric adenocarcinoma and its correlation with histopathological features and lymph node metastasis

Retrospective Analysis of Complications and Causes of Mortality in Patients Undergoing Esophagectomy for Esophageal Cancer

Research on Associations of MiR-149 with Nutritional Risk Assessment and Postoperative Complications of Patients with Colorectal Cancer

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