CD105/Ki67 Coexpression Correlates With Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer

Liu, Ping; Sun, Yu-Lei; Du, Jie; Hou, Xiao-Sai; Meng, Hua

doi:10.1097/igc.0b013e31823c36b8

Cited by 35 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ziebarth et al demonstrated that forced ENG inhibition resulted in decreased cell viability, increased apoptosis, induced double-stranded DNA damage, and increased cisplatin sensitivity in ovarian cancer cell lines (50). In our study, ENG was upregulated in the wt TP53 cell lines and was a surprising finding given the association between increased ENG staining in MCV or tumor-associated endothelial cells and advanced stage disease, suboptimal cytoreduction (51), and increased disease progression (52, 53). There are conflicting results regarding the association between ENG and survival (51, 54, 55).…”

Section: Discussionmentioning

confidence: 55%

“…There are conflicting results regarding the association between ENG and survival (51, 54, 55). High ENG expression in combination with high transforming growth factor B levels prior to chemotherapy have been associated with improved overall survival (55) while others have reported either decrease survival for those with the highest levels of ENG expression (51, 53) or no relationship at all (54). Previously, we used ENG staining to determine MVD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines

et al. 2014

View full text Add to dashboard Cite

Objectives: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to study the interaction between TP53 mutational status and hypoxia on angiogenic gene expression.Methods: Affymetrix U133A arrays were analyzed for angiogenic gene expression in 19 ovarian cancer cell lines stratified both by TP53 mutation status and A2780 wild-type (wt) TP53 vs. mutated (m) TP53 cell lines after treatment under hypoxic conditions or with ionizing radiation.Results: Twenty-eight differentially expressed angiogenic genes were identified in the mTP53 cell lines compared to wtTP53 lines. Five genes were upregulated in mTP53 cells: 40% involved in extracellular matrix (ECM) degradation [matrix metalloproteinase 10 (MMP10)/15] and 60% in angiogenesis (fibroblast growth factor receptor 3/VEGFA/ephrin receptor-B4). Twenty-three genes were upregulated in wtTP53: nearly 22% were ECM constituents or involved in ECM degradation; over 40% were growth factors or mediators of angiogenesis. Five genes were upregulated in the A2780mTP53 cells: 40% involved in ECM remodeling (MMP10, ADAMTS1), 40% with pro-angiogenic activity (EFNB2, factor 2 receptor), and 20% with anti-angiogenic properties (ADAMTS1). Three genes were upregulated in hypoxia treated cells compared to controls: one with anti-angiogenic activity (angiopoietin-like 4) and two with pro-angiogenic activity (VEGFA, EFNA3). No significant gene fold changes were noted after exposure to radiation. Four genes continued to demonstrate significant differential expression (p ≤ 0.05) after adjusting for multiple comparisons. These genes included endoglin upregulation in wt lines (pro-angiogenesis) and upregulation of FGF20 (growth factor), ADAMTS1 (anti-angiogenesis) and MMP10 (ECM degradation) in mTP53 cell lines.Conclusion: Our exploratory findings indicate that non-overlapping angiogenic pathways may be altered by TP53 mutations and hypoxic conditions in the tumor microenvironment. Further evaluation is needed for confirmation.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Ki-67 is essential for cell proliferation (Liu et al, 2012). Ki-67 is required for the synthesis of ribosomes during the cell cycle.…”

Section: Discussionmentioning

confidence: 99%

“…In various studies the relationship between MVD (by using CD105 marker) and factors such as metastasis, Stage of tumor, proliferation rate of tumor cells and survival has been investigated (Liu et al, 2012), but in salivary gland tumors, the association between this factor and tumor cell proliferation rate has not been studied, therefore this study was based on investigating the relationship between these two factors.…”

Section: Introductionmentioning

confidence: 99%

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61±3.1) as compared to PA (0.46±0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7±10.8 respectively) compared to PA (50% and 0.78±0.2) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

show abstract

“…Recently, Ki67 was identified as an important prognostic factor for many tumor entities with respect to chemosensitivity and disease recurrence/death (Falato et al 2014;Li et al 2016;Rowe et al 2016). Its prognostic value in ovarian carcinoma remains controversial (Liu et al 2012;Masoumi-Moghaddam et al 2015;Feng et al 2016;Green et al 2016) and its correlation with VASH1 is not well known. The present study demonstrated that the high Ki67 expression group had a good prognosis but that there were no significant differences.…”

Section: Discussionmentioning

confidence: 99%

Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma

Sano

Kanomata

Suzuki

et al. 2017

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Vasohibin-1 (VASH1) is an identified negative feedback inhibitor of angiogenesis induced by vascular endothelial growth factor (VEGF) in vascular endothelial cells (ECs). Expression of VASH1 has been reported not only in ECs of normal tissue, but also in ECs surrounding malignant tumors. In malignant tumors, VASH1 is also gaining attention as a prognosis prediction marker. The aim of this study is to investigate the correlation between VASH1 expression and vascular-related factors and various clinicopathological outcomes in clinical cases of ovarian carcinoma. We retrospectively analyzed clinical records of 58 patients with ovarian carcinoma. The expression patterns of VASH1 and other vascularrelated factors (CD31 as markers of microvessel density (MVD), VEGF receptor type 2 (VEGFR2), D2-40 as markers of lymphovessel density), and Ki67 (as proliferation markers of cancer cells) were examined immunohistochemically. We studied the correlation between immunohistochemical expression and overall survival. VASH1 expression pattern significantly differed between Federation of Obstetrics and Gynecology (FIGO) Stages. Numbers of VASH1-positive vessels had a significant positive correlation with MVD (Speaman's correlation coefficient (ρ) was 0.51, p < 0.001), VEGFR2-positive vessels (ρ = 0.61, p < 0.001), and percentage of Ki67 (ρ = 0.28, p = 0.034). The Cox univariable analyses revealed that the group of high VASH1 expression (> 14.6 vessels per mm 2 ) at Stages I-III is a prognostic factor (HR = 3.3, 95%CI = 0.4-8.4; p = 0.013). Our results indicate that VASH1 expression in ovarian carcinoma is significantly associated with vascular-related factors and Ki67 expression. We propose that VASH1 is a prognostic marker in ovarian carcinoma.

show abstract

CD105/Ki67 Coexpression Correlates With Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer

Abstract: Our results suggest that the CD105 and Ki67 expressions might be involved in the progression of EOC and patient prognosis. A combined detection of CD105/Ki67 coexpression may benefit us in predicting the prognosis in EOC.

Cited by 35 publications

References 26 publications

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma

Contact Info

Product

Resources

About