CD117 Expression in Squamous Cell Carcinoma of the Oesophagus

Moreira, Luís Fernando; Maino, Marcelo Marafon; Garbin, Henrique Iahnke; Natividade, Gabriella Richter da; Volkweis, Bernardo Silveira; Kulczynski, Jane

doi:10.21873/anticanres.12678

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…(8)(9)(10)(11) In fact, the amplification and overexpression of p63 has been frequently observed in lung cancers and in head and neck cancers. (11) The expression of DNp63 is reported to be significantly lower in invasive ESCC and to have a negative correlation with poor prognosis (33) whereas the expression of p63 decreases during the progression of lung, breast, and bladder cancer. Moreover, the loss of p63 expression is associated with poor prognosis in some cases.…”

Section: Discussionmentioning

confidence: 99%

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma

Kumakura

Rokudai²,

Iijima

et al. 2017

Cancer Science

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This study aims to explore the expression level of ΔNp63 in esophageal squamous cell carcinoma (ESCC). To investigate the association between ΔNp63 (p40) expression and ESCC biology, we compared the levels of ΔNp63 expression in normal and tumor tissues, with a specific focus on the diagnostic value of ΔNp63 in ESCC. We analyzed 160 consecutive patients with ESCC who underwent surgical resection without neoadjuvant chemotherapy at Gunma University Hospital (Maebashi, Japan) between September 2000 and January 2010. The clinicopathological characteristics and survival of patients were subclassified based on the expression of ΔNp63 as determined by immunohistochemistry, indicating that ΔNp63 was highly expressed in 75.6% (121/160) of ESCC patients. Clinicopathological analysis of ΔNp63 expression showed that ΔNp63‐positive tumors significantly correlated with two important clinical parameters: T factor (P = 0.0316) and venous invasion (P = 0.0195). The 5‐year overall survival rates of advanced ESCC patients with positive and negative expression of ΔNp63 were 35.6% and 71.7%, respectively. Multivariate analysis revealed that the expression of ΔNp63 was identified as an independent prognostic factor (P = 0.0049) in advanced ESCC. In line with this, ΔNp63α‐transduced ESCC cell lines increased tumor growth in a soft agar colony formation assay. We report here for the first time that ΔNp63 expression increases the oncogenic potential of ESCC and is an independent marker for predicting poor outcome in advanced ESCC. Our findings suggest that ΔNp63 could serve as a new diagnostic marker for ESCC and might be a relevant therapeutic target for the treatment of patients with this disease.

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Section: Discussionmentioning

confidence: 99%

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma

Kumakura

Rokudai²,

Iijima

et al. 2017

Cancer Science

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“…Currently, there are few studies investigating the molecular expression of KITLG and c-KIT in veterinary medicine, mostly in canine mast cell tumors [ 38 , 39 , 40 , 41 , 42 ] and gastrointestinal stromal tumors [ 42 , 43 , 44 ], with no descriptions of specific immunolabeling in canine SCC or DSCC. In human medicine, there have been attempts to perform immunohistochemistry for c-KIT on SCC [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. In the literature, there are reports that between 12.5% and 20% [ 45 , 46 , 47 , 50 ] of SCCs have any kind of sparse immunopositivity.…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, there have been attempts to perform immunohistochemistry for c-KIT on SCC [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. In the literature, there are reports that between 12.5% and 20% [ 45 , 46 , 47 , 50 ] of SCCs have any kind of sparse immunopositivity. In a single study, the expression of c-KIT in esophageal SCC was correlated with a worse prognosis, only being expressed in 29.9% of the specimens [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs and Copy Number Variation of KIT Ligand—A Correlation Study

Cerezo-Echevarria

Kehl

Beitzinger

et al. 2023

Veterinary Sciences

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Dark-haired dogs are predisposed to the development of digital squamous cell carcinoma (DSCC). This may potentially suggest an underlying genetic predisposition not yet completely elucidated. Some authors have suggested a potential correlation between the number of copies KIT Ligand (KITLG) and the predisposition of dogs to DSCC, containing a higher number of copies in those affected by the neoplasm. In this study, the aim was to evaluate a potential correlation between the number of copies of the KITLG and the histological grade of malignancy in dogs with DSCC. For this, 72 paraffin-embedded DSCCs with paired whole blood samples of 70 different dogs were included and grouped according to their haircoat color as follow: Group 0/unknown haircoat color (n = 11); Group 1.a/black non-Schnauzers (n = 15); group 1.b/black Schnauzers (n = 33); group 1.c/black and tan dogs (n = 7); group 2/tan animals (n = 4). The DSCCs were histologically graded. Additionally, KITLG Copy Number Variation (CNV) was determined by ddPCR. A significant correlation was observed between KITLG copy number and the histological grade and score value. This finding may suggest a possible factor for the development of canine DSCC, thus potentially having an impact on personalized veterinary oncological strategies and breeding programs.

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“…The potential benefit of targeted therapy with tyrosine kinase inhibitors such as toceranib is a therapeutic modality of growing interest for feline SCC. However, to our knowledge, it has not been evaluated in this location in cats, and the expression of KIT (CD117) was recently found to be infrequent (<15 per cent) in oesophageal SCC in human 19. The poor condition of the cat discouraged any therapeutic trial.…”

Section: Discussionmentioning

confidence: 99%

Primary oesophageal squamous cell carcinoma in a cat with bradycardia and ionised hypercalcaemia

Denoeux¹,

Hugonnard²,

Krafft³

2019

Vet Record Case Reports

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An adult male domestic shorthair cat was presented for vomiting and anorexia, with a three-month history of weight loss. Bradycardia was documented during physical examination and was diagnosed as sinusal by electrocardiography. Blood electrolytes analysis revealed a marked ionised hypercalcaemia. Thoracic radiographs revealed a large soft tissue opacity at the level of the distal oesophagus. Subsequent thoracic ultrasonography and oesophagoscopy confirmed the presence of a tissue mass infiltrating distal oesophagus, oesophagogastric junction and neighbouring tissues. After biopsy and histopathological analysis, a squamous cell carcinoma (SCC) was diagnosed. Sinus bradycardia was assumed to be related to an increased vagal tone due to the close proximity of the vagal nerve with the infiltrative lesion or, less likely, severe hypercalcaemia. This case describes an atypical clinical presentation of an SCC in an uncommon location. Furthermore, to the authors’ knowledge, this is the first report of hypercalcaemia associated with oesophageal SCC in a cat.

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CD117 Expression in Squamous Cell Carcinoma of the Oesophagus

Abstract: Although immunohistochemical expression of CD117 was higher than previously demonstrated, the lack of expression does not warranty further use in targeted therapy of SCCO.

Cited by 9 publications

References 12 publications

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma

Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs and Copy Number Variation of KIT Ligand—A Correlation Study

Primary oesophageal squamous cell carcinoma in a cat with bradycardia and ionised hypercalcaemia

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