CD13 (human aminopeptidase N) mediates human cytomegalovirus infection

Söderberg, Cecilia; Giugni, Terrence D.; Zaia, John A.; Larsson, Susanne; Wahlberg, J M; Möller, Erna

doi:10.1128/jvi.67.11.6576-6585.1993

Cited by 123 publications

(92 citation statements)

References 38 publications

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“…In biological systems, their primary peptide substrates include a wide variety of neuropeptides and hormones [14,15]. It has been established as a myelomonocytic marker in leukemia typing [16], as a receptor for human coronavirus 229E and cytomegalovirus [17,18], as a mediator of both inflammation and cell invasion [16], as a regulator of blood pressure and the pathogenesis of hypertension [19], and as a regulator of analgesia via metabolism of endorphins and enkephalins [20]. Furthermore, it also regulates IL-8 bioavailability in the endometrium and therefore may contribute to the process of angiogenesis [21].…”

Section: Classification Of Metallo-aminopeptidasesmentioning

confidence: 99%

Metallo-aminopeptidase inhibitors

et al. 2010

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Aminopeptidases are enzymes that selectively hydrolyze an amino acid residue from the N-terminus of proteins and peptides. They are important for the proper functioning of prokaryotic and eukaryotic cells, but very often are central players in the devastating human diseases like cancer, malaria and diabetes. The largest aminopeptidase group include enzymes containing metal ion(s) in their active centers, which often determines the type of inhibitors that are the most suitable for them. Effective ligands mostly bind in a non-covalent mode by forming complexes with the metal ion(s). Here, we present several approaches for the design of inhibitors for metallo-aminopeptidases. The optimized structures should be considered as potential leads in the drug discovery process against endogenous and infectious diseases.

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Section: Classification Of Metallo-aminopeptidasesmentioning

confidence: 99%

Metallo-aminopeptidase inhibitors

et al. 2010

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“…Viral targeting of APN and its subsequent down-regulation is definitely a known phenomenon, as this cellular peptidase possibly is implicated in infection with human cytomegalovirus (CMV) also. [85][86][87] Notwithstanding the fact that human APN is most likely not the primary receptor of the virus, 88 CMV induces abrogation of APN expression. 85,86 The phenomenon of entry receptor suppression has been reported for several additional viruses, including HIV, measles virus (MV), influenza virus, and human herpes virus (HHV) type 6.…”

Section: Cellular Receptor Modulation: a Pathway To Human Coronavirusmentioning

confidence: 99%

Recently Discovered Human Coronaviruses

Wevers¹,

Hoek

2009

Clinics in Laboratory Medicine

101

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In marked contrast to their historical classification as relatively harmless, common cold-causing, respiratory pathogens, human coronaviruses (HCoVs) are associated with more severe clinical complications, as emphasized by the discovery of severe acute respiratory syndrome-associated CoV (SARS-CoV) in 2003. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified strains HCoV-NL63 and HCoV-HKU1, and definite proof for their etiology remains a major challenge. This article focuses on the characteristics of the five HCoVs that are known, and summarizes current knowledge of their pathogenic potential in people, with an emphasis on the interactions between these viruses and their cognate receptors on susceptible target cells.

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“…16,17 APN has also been shown to mediate human cytomegalovirus (HCMV) infection. 18 The inhibition or neutralization of HCMV infection by soluble APN implicates the possibility of using soluble APN as an antiviral agent.…”

Section: Introductionmentioning

confidence: 99%