2019
DOI: 10.7150/thno.29617
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CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages

Abstract: Rationale: Bone is one of the most common metastatic sites of breast cancer. CD137 (4-1BB), a member of the tumor necrosis factor (TNF) receptor superfamily, is mainly expressed in activated leukocytes. Previous study demonstrates the effect of CD137-CD137L bidirectional signaling pathway on RANKL-mediated osteoclastogenesis. However, the role of CD137 in bone metastasis of breast cancer needs further study. Methods: Stable monocyte/macrophage cell lines with Cd13… Show more

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Cited by 69 publications
(48 citation statements)
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“…Although TAMs are an ontogenetically heterogeneous population, they exhibit many similar characteristics to M2 macrophages, including an anti-inflammatory phenotype and the state of activation and localization 20 . TAMs exert immunosuppressive effects on tumor-infiltrating lymphocytes and secrete anti-inflammatory cytokines and chemokines, such as CCL18 or Arg1, which directly enhance tumor progression 7 , 30 . In breast cancer, CCL18 produced by TAMs has been reported to promote cancer metastasis via PITPNM3-dependent calcium signaling activation 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Although TAMs are an ontogenetically heterogeneous population, they exhibit many similar characteristics to M2 macrophages, including an anti-inflammatory phenotype and the state of activation and localization 20 . TAMs exert immunosuppressive effects on tumor-infiltrating lymphocytes and secrete anti-inflammatory cytokines and chemokines, such as CCL18 or Arg1, which directly enhance tumor progression 7 , 30 . In breast cancer, CCL18 produced by TAMs has been reported to promote cancer metastasis via PITPNM3-dependent calcium signaling activation 24 .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, abnormal adhesion of tumor cells is associated with tumor progression and metastasis ( 65 ). In addition to the above, DEGs were also related to pathways such as osteoclast differentiation, which is involved in the bone metastasis of breast cancer ( 66 , 67 ), TNF signaling pathway, and Wnt signaling pathway, which are related to the progression and metastasis of melanoma ( 68 , 69 ).…”
Section: Discussionmentioning
confidence: 99%
“…Several TNFSF members are also involved in the RANKL-independent osteoclast differentiation program. Of them, CD137 promotes osteoclast migration and differentiation in breast cancer-induced bone metastasis [7]. Mice deficient in TNFSF14 show increased bone mass together with suppressed osteoclastic resorption [8].…”
Section: Introductionmentioning
confidence: 99%