CD138 promotes the accumulation and activation of autoreactive T cells in autoimmune MRL/lpr mice

Xie, Tianhong; Liu, Xin; Li, Ping

doi:10.3892/etm.2023.12267

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…However, CD138 expression could significantly increase FasL expression in DN T cells. 41 CD138 expression will significantly prevent the apoptosis of CD3+ T cells and significantly contribute to the accumulation of DN T cells in MRL/lpr mice. 41 Celastrol significantly prevented DN T cell accumulation in MRL/lpr mice and strikingly reduced CD138+ cell accumulation in DN T cells.…”

Section: Discussionmentioning

confidence: 99%

“… 41 CD138 expression will significantly prevent the apoptosis of CD3+ T cells and significantly contribute to the accumulation of DN T cells in MRL/lpr mice. 41 Celastrol significantly prevented DN T cell accumulation in MRL/lpr mice and strikingly reduced CD138+ cell accumulation in DN T cells. Our study demonstrated that celastrol could prevent the autoimmune response by reducing CD138+ cell frequency in DN T cells and subsequently decrease DN T cell accumulation to avoid tissue injury and self-antigen exposure induced by overexpressed FasL in DN T cells.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…CD138 expression in CD3+ T cells significantly promotes the activation of CD3+ T cells in MRL/lpr mice, accelerating the autoimmune response in MRL/lpr mice. 41 Recent studies have found that CD138+ T cells could strikingly contribute to the formation of plasma cells from B cells of MRL/lpr mice. 33 34 In the present study, we observed significantly reduced production of ANA and anti-dsDNA antibodies in the serum of celastrol-treated MRL/lpr mice.…”

Section: Discussionmentioning

confidence: 99%

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Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice

Xie,

Rui,

Liu

et al. 2024

Lupus Sci Med

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ObjectiveCelastrol is a bioactive constituent extracted fromTripterygium wilfordii(thunder god vine). It has been demonstrated to have a therapeutic effect on experimental disease models for chronic inflammatory and immune disorders. In the present study, we investigated whether and how celastrol exerts a regulatory effect on the autoimmune response in MRL/lpr mice.MethodsWe performed an in vivo study to determine the therapeutic effects of celastrol in MRL/lpr mice and then further investigated the underlying mechanism of celastrol in the regulation of the autoimmune response in MRL/lpr mice.ResultsCelastrol showed a therapeutic effect in MRL/lpr mice by preventing the enlargement of the spleen and lymph nodes, alleviating renal injury, and reducing the levels of ANA and anti-double-stranded DNA antibodies. Furthermore, celastrol suppressed the in vivo inflammatory response in MRL/lpr mice by reducing the serum levels of multiple cytokines, including interleukin (IL)-6, tumour necrosis factor (TNF) and interferon (IFN)-γ, and the production of multiple antibody subsets, including total IgG, IgG1and IgG2b. In vitro, celastrol reduced anti-CD3 antibody stimulation-induced T helper 1 and TNF-producing cells in CD4+ T cells of MRL/lpr mice. In addition, celastrol significantly affected B cell differentiation and prevented the generation of plasma cells from B cells in MRL/lpr mice by reducing the frequency of activated and germinal centre B cells. Celastrol treatment also affected T cell differentiation and significantly reduced central memory T cell frequencies in MRL/lpr mice. Importantly, celastrol treatment specifically promoted apoptosis of CD138+ but not CD138− T cells to suppress autoimmune T cell accumulation in MRL/lpr mice.ConclusionsCelastrol exerted therapeutic effects on lupus by specifically promoting apoptosis of autoimmune T cells and preventing the progression of autoimmune response.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice

Xie,

Rui,

Liu

et al. 2024

Lupus Sci Med

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QCMAM: Quantitative Clustering Method for Machine Learning integrating Attention Mechanism

Chai,

Xiao,

Jiang

et al. 2024

2024 IEEE 9th International Conference on Computational Intelligence and Applications (ICCIA)

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Syndecans in hematopoietic cells and their niches

Hagen,

Setiawan,

Woodruff

et al. 2024

American Journal of Physiology-Cell Physiology

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Heparan sulfate proteoglycans are a family of glycoproteins that modulate cell signaling by binding growth factors and changing their bioavailability. Syndecans are a specific family of transmembrane heparan sulfate proteoglycans that regulate cell adhesion, migration, and signaling. In this review, we will summarize emerging evidence for the functions of Syndecans in the normal and malignant blood systems and their microenvironments. More specifically, we detail the known functions of Syndecans within normal hematopoietic stem cells. Further, we discuss the functions of Syndeans in hematological malignancies, including myeloid malignancies, lymphomas, and bleeding disorders. As normal and malignant hematopoietic cells require cues from their microenvironments to function, we also summarize the roles of Syndecans in cells of the stroma, endothelia, and osteolineage compartments. Syndecan biology is a rapidly evolving field; a comprehensive understanding of these molecules and their place in the hematopoietic system promises to improve our grasp on disease processes and better predict the efficacies of growth factor-targeting therapies.

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CD138 promotes the accumulation and activation of autoreactive T cells in autoimmune MRL/lpr mice

Cited by 4 publications

References 38 publications

Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice

Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice

QCMAM: Quantitative Clustering Method for Machine Learning integrating Attention Mechanism

Syndecans in hematopoietic cells and their niches

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