CD14 and development of atopic disease at 2 years of age in children with atopic or non‐atopic mothers

Holmlund, Ulrika; Höglind, Ankie; Larsson, Anna‐Karin; Nilsson, Caroline; Sverremark-Ekström, Eva

doi:10.1046/j.1365-2222.2003.01629.x

Cited by 19 publications

(24 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, sCD14 has been associated with inhibition of immunoglobulin E production (15,32). However, in keeping with our results, no association between serum sCD14 and allergic disease status of the child has been observed (8,31), but higher cord blood sCD14 levels in children with transient atopy during a 5-y follow-up (8) and lower sCD14 levels in atopic children have been reported (33).…”

Section: Serum and Milk Immunomodulatory Factorssupporting

confidence: 83%

“…According to experimental studies, the availability of sCD14 appears to be rate limiting for the amount of lipid passing out from cell membranes to media (9). Considering our results on higher sCD14 in breast milk received by infants with atopic eczema and also the previous observation of a higher serum sCD14 concentration in atopic mothers compared with those without (31), it may be that the patients with allergic disease have a reduced capacity to exploit sCD14. Alternatively, breast milk sCD14 levels may play a role in mediating responses to beneficial bacteria (7), and the resultant reduced availability of sCD14 via breast milk would increase the risk of infant's eczema, as previously reported (8).…”

Section: Serum and Milk Immunomodulatory Factorssupporting

confidence: 58%

See 1 more Smart Citation

Breast Milk Fatty Acids May Link Innate and Adaptive Immune Regulation: Analysis of Soluble CD14, Prostaglandin E2, and Fatty Acids

et al. 2006

View full text Add to dashboard Cite

In addition to its role in sensing intraluminal microbial antigens, soluble (s)CD14 may regulate immune responses by its lesser known function as a lipid carrier with possible influences in the production of fatty acid-derived eicosanoids. We investigated the interrelations of fatty acids, prostaglandin E 2 (PGE 2 ), and sCD14 and their role in infant atopic eczema during the first year of life. Serum and breast milk samples from mothers and serum samples from their infants were collected at infant's age 3 mo and analyzed for sCD14 and PGE 2 concentrations and for fatty acid compositions. The main correlation of sCD14 was with arachidonic acid (20:4n-6) (AA). Dihomo-␥-linolenic acid (20:3n-6) (DHGLA) and the ratio of n-6 to n-3 fatty acids correlated positively and docosahexaenoic acid (22:6n-3) (DHA) and sum of n-3 fatty acid negatively with PGE 2 in mother's serum and linoleic acid (LA) negatively with PGE 2 in breast milk. Soluble CD14 tended to be higher and LA, total polyunsaturated fatty acid (PUFA), and sum of n-6 fatty acids were lower in breast milk received by infants with atopic eczema compared with those without. These results suggest that fatty acids contribute to the regulation of innate and adaptive immune responses and link intraluminal exposures, mother's diet, and microbes. C haracteristic dietary habits in Western societies have constantly been linked to chronic diseases such as diabetes, cardiovascular diseases, and more recently allergic diseases. The accumulating data point to the early fetal period and infancy as the critical phase (1). Specific dietary compounds, including fatty acids and probiotics, have been exploited in the development of prophylactic and therapeutic interventions, the effects ensuing through their immunomodulatory properties (2). For the infant, the effects are drawn together by outstanding breast milk composition, providing not only nourishment but also signals for the maturation of the adaptive immune responses considered imperative with regard to the risk of diseases (3).Although the major function described for soluble (s)CD14, a pattern recognition receptor, is binding of lipopolysaccharides and thus antimicrobial host defense (4), its binding specificity is not restricted to bacteria. It also binds phospholipids, thus providing a lipid transfer system (5). This innovative function of sCD14 may prove significant, with a potential to modify immune events through phospholipid polyunsaturated fatty acids (PUFAs). Both dietary and cellular fatty acids are evidently important immune regulators via their derivative eicosanoids, particularly PGE 2 and consequent cytokine responses, as suggested in allergic disease (6). The concentration of sCD14 in breast milk has been shown to be up to 20-fold higher than in serum (7), thus providing infants with an external source of sCD14 with potential health benefits as previously observed in allergic disease (8). Experimental studies have linked sCD14 to phospholipid transport in blood (5,9) and a positive correlation be...

show abstract

Section: Serum and Milk Immunomodulatory Factorssupporting

confidence: 83%

Section: Serum and Milk Immunomodulatory Factorssupporting

confidence: 58%

Breast Milk Fatty Acids May Link Innate and Adaptive Immune Regulation: Analysis of Soluble CD14, Prostaglandin E2, and Fatty Acids

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The cord blood provides a unique opportunity to investigate the immunity of newborns prior to disease onset as well as representing a bond between mother and child. Only in atopic mothers have sCD14 levels at the time of delivery been found to be related to the cord blood sCD14 of their children [41] . In our birth cohort, one limitation was that maternal sCD14 levels were not checked at the time of delivery.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood Soluble CD14 Predicts Wheeze and Prolonged Cough in Young Children: The PATCH Study

Tu²,

Chiu³

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

cord blood sCD14, older maternal age and more siblings. In the multivariate logistic regression analysis, cord blood sCD14 was the only independent predictive biomarker for wheeze and prolonged cough by 1 year of age. Every 100-ng/ml increase in cord blood sCD14 resulted in a 1.56-fold higher risk of developing wheeze and a 1.62-fold higher risk of prolonged cough in children by 1 year of age. Conclusions: Cord blood sCD14 may be a useful biomarker for predicting infant wheeze and prolonged cough by 1 year of age.

show abstract

“…Soluble CD14 can modulate the activity of LPS and additional TLR ligands (13,25) and has been reported to be expressed at lower levels at birth (26), raising the possibility that differences in the sCD14 content of newborn and adult plasma may contribute to the plasma modulating effects observed (i.e., Fig. 8).…”

Section: Figure 5 Phosphorylation Of Monocyte P38mentioning

confidence: 99%

Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF-α Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

Levy

Zarember²,

Roy

et al. 2004

The Journal of Immunology

341

330

View full text Add to dashboard Cite

Newborns are at increased risk of overwhelming infection, yet the mechanisms underlying this susceptibility are incompletely defined. In this study we report a striking 1- to 3-log decrease in sensitivity of monocytes in human neonatal cord blood, compared with monocytes in adult peripheral blood, to the TNF-α-inducing effect of multiple TLR ligands, including bacterial lipopeptides (BLPs), LPS, and the imidazoquinoline compound, imiquimod. In marked contrast, TNF-α release in response to R-848, a TLR ligand that is a congener of imiquimod, was equivalent in newborn and adult blood. Differences in ligand-induced TNF-α release correlated with divergent ligand-induced changes in monocyte TNF-α mRNA levels. Newborn and adult monocytes did not differ in basal mRNA or protein expression of TLRs or mRNA expression of functionally related molecules. Newborn monocytes demonstrated diminished LPS-induced, but equivalent R-848-induced, phosphorylation of p38 mitogen-activated protein kinase and altered BLP- and LPS-induced acute modulation of cognate receptors, suggesting that the mechanism accounting for the observed differences may be localized proximal to ligand recognition by surface TLRs. Remarkably, newborn plasma conferred substantially reduced BLP-, LPS-, and imiquimod-induced TNF-α release on adult monocytes without any effect on R-848-induced TNF-α release, reflecting differences in a plasma factor(s) distinct from soluble CD14. Impaired response to multiple TLR ligands may significantly contribute to immature neonatal immunity. Conversely, relative preservation of responses to R-848 may present unique opportunities for augmenting innate and acquired immunity in the human newborn.

show abstract

CD14 and development of atopic disease at 2 years of age in children with atopic or non‐atopic mothers

Abstract: Based on our findings, we suggest that CD14 could be involved in the regulation of IgE production, but that it might also be important for the maturation and development of the neonatal immune system.

Cited by 19 publications

References 42 publications

Breast Milk Fatty Acids May Link Innate and Adaptive Immune Regulation: Analysis of Soluble CD14, Prostaglandin E2, and Fatty Acids

Breast Milk Fatty Acids May Link Innate and Adaptive Immune Regulation: Analysis of Soluble CD14, Prostaglandin E2, and Fatty Acids

Cord Blood Soluble CD14 Predicts Wheeze and Prolonged Cough in Young Children: The PATCH Study

Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF-α Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

Contact Info

Product

Resources

About