CD14 and TNFα promoter polymorphisms in patients with acute arthritis

Repo, Heikki; Anttonen, Krista; Kilpinen, Sami; Palotie, Aarno; Salvén, Petri; Orpana, Arto; Leirisalo‐Repo, Marjatta

doi:10.1080/030097402320817086

Cited by 12 publications

(1 citation statement)

References 15 publications

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“…DNA for CD14 2159 determination was isolated using QIAamp DNA blood midi kit (Qiagen, Hilden, Germany), and the polymorphism was analysed by cycle minisequencing. 10 …”

Section: Patientsmentioning

confidence: 99%

Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis

Kuuliala

Orpana

Leirisalo‐Repo

et al. 2006

Annals of the Rheumatic Diseases

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The aim of this study was to determine whether the +896 ARG substitution of the Toll-like receptor 4 (TLR4) gene, causing the Asp299RGly change in the extracellular domain of TLR4, influences treatment response in recent-onset rheumatoid arthritis. 169 patients with rheumatoid arthritis were genotyped from the Finnish Rheumatoid Arthritis Combination Therapy trial, in which they were treated either with only one disease-modifying antirheumatic drug (DMARD) with or without prednisolone (single group), or with three DMARDs and prednisolone (combination group). Patients homozygotic for the wild-type +896A allele were compared with those having the polymorphic G allele in terms of early clinical response (at 6 months) by the 28-joint Disease Activity Score (DAS28). 1 of 20 (5%; (95% (confidence interval (CI) 1 to 5)) patients of the single group with TLR4 +896AG or GG and 29 of 67 (43%; (95% CI 31 to 56)) patients with AA were in remission (p = 0.001). DAS28 of the single group with TLR4 +896AG or GG was higher than with AA (p = 0.019). In the combination group, remission rates and DAS28 values were comparable between the genotypes. The polymorphic TLR4 +896G allele may impair treatment response to single DMARD treatment in recent-onset rheumatoid arthritis.

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“…DNA for CD14 2159 determination was isolated using QIAamp DNA blood midi kit (Qiagen, Hilden, Germany), and the polymorphism was analysed by cycle minisequencing. 10 …”

Section: Patientsmentioning

confidence: 99%