CD14 C(−260)T gene polymorphism, circulating soluble CD14 levels and arteriosclerosis

Amar, Jacques; Ruidavets, Jean‐Bernard; Sollier, Claire Bal dit; Bongard, Vanina; Boccalón, H; Chamontin, B.; Drouet, Ludovic; Ferrières, Jean

doi:10.1097/01.hjh.0000133724.16947.a3

Cited by 27 publications

(22 citation statements)

References 34 publications

(51 reference statements)

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“…Taking into account the anti-inflammatory role of HDL in reducing CD14 expression [29] and the existence of an interplay among HDL, triglycerides and carotid intimamedia thickness [33,34], these findings seem to indicate a pathogenetic role in the interaction between the genetically determined CD14 hyper-expression and pro-atherogenic lipoprotein profile. Indeed, consistent with the findings from other authors [6,8,15,16,35], patients with TT genotypes displayed a series of altered parameters related to the development and progression of atherosclerosis, such as enhanced plasma concentration of sCD14 and lipid serum profile (low HDL and high triglycerides). Since the number of hypercholesterolemic patients was small, further studies in a larger population will be required to confirm the influence of -260 CD14 polymorphism on HDL cholesterol and triglyceride serum concentrations.…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

Giacconi

Caruso

Lio

et al. 2007

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 86%

“…TT genotype was found to be associated with a major production of sCD14 both in [15] and carotid stenosis or peripheral atherosclerosis patients [16].…”

Section: Introductionmentioning

confidence: 99%

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

Giacconi

Caruso

Lio

et al. 2007

International Journal of Cardiology

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“…187 Soluble CD14 has been shown to increase cellular responses to LPS both in vivo and in vitro. 188 Inflammatory atherosclerotic disease has been reported to significantly elevate plasma sCD14 concentration and markers of chronic inflammation compared to normal individuals. [189][190][191] Plasma sCD14 concentration has also been linked to the pathophysiology of other inflammatory disease states.…”

Section: Accessory Proteinsmentioning

confidence: 99%

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

Flynn

McFarlin

Markofski³

2007

American Journal of Lifestyle Medicine

111

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The list of diseases with a known inflammatory etiology is growing. Cardiovascular disease, osteoporosis, diabetes, geriatric cachexia, and Alzheimer's disease have all been shown to be linked to or exacerbated by aberrantly regulated inflammatory processes. Nevertheless, there is mounting evidence that those who are physically active, or who become physically active, have a reduction in biomarkers associated with chronic inflammation. There was strong early consensus that exercise-induced reductions in inflammation were explained by body mass index or body fatness, but recent studies provide support for the contention that exercise has body fatindependent anti-inflammatory effects. With few exceptions, the anti-inflammatory effects of exercise appear to occur regardless of age or the presence of chronic diseases. What remains unclear are the mechanisms by which exercise training induces these anti-inflammatory effects, but there are several intriguing possibilities, including release of endogenous products, such as heat shock proteins; selective reduction of visceral adipose tissue mass or reducing infiltration of adipocytes by macrophages; shift in immune cell phenotype; cross-tolerizing effects; or exerciseinduced shifts in accessory proteins of toll-like receptor signaling. However, future research endeavors are likely to uncover additional potential mechanisms, and it could be some time before functional mechanisms are made clear. In summary, the potential anti-inflammatory influences of exercise training may provide a low-cost, readily available, and effective treatment for low-grade systemic inflammation and could contribute significantly to the positive effects of exercise training on chronic disease. Keywordsanti-inflammatory; exercise training; chronic disease Cardiovascular disease, diabetes, osteoporosis, and several other chronic diseases are now known to be strongly linked to inflammatory processes. [1][2][3][4] Chronic diseases linked to inflammation are known to occur in greater frequency in older and sedentary individuals, 5 but evidence is emerging that exercise has anti-inflammatory effects. [6][7][8][9] For example, there is a substantial reduction in biomarkers of low-grade systemic inflammation in physically active adults or adults who undertake exercise training. [10][11][12][13][14] Address for correspondence: Michael G. Flynn, FACSM, Wastl Human Performance Lab, Department of Health and Kinesiology, Purdue University West Lafayette, IN 47907; mickflyn@purdue.edu. NIH Public Access Author ManuscriptAm J Lifestyle Med. Author manuscript; available in PMC 2014 November 25. NIH-PA Author ManuscriptChronic low-grade inflammation, "persistent but more subtle than the acute phase response," 15 is frequently assessed by measurement of circulating C-reactive protein (CRP) and, somewhat less frequently, serum amyloid A. C-reactive protein concentration is higher in those with high body mass index, 16,17 metabolic syndrome and/or diabetes, 1,18 belownormal high-density lipoprotein choleste...

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“…However, this result might be modified by smoking, as a significant interaction was observed between smoking and CD14 genotype in sCD14 expression. [16] Our study did not show any significant interaction between smoking and CD14 polymorphism. Another study [14] reported that the CC genotype was associated with an increased cardiovascular mortality in dialysis patients in the subgroup of hypertensive and non-smoking subjects.…”

Section: Discussionmentioning

confidence: 58%

Association between Decreased Kidney Function and Endotoxin ReceptorCD14C-159T Polymorphism among Japanese Health Check-up Examinees

Okada¹,

Suzuki²,

Ito³

et al. 2007

Renal Failure

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Background.A recently identified promoter polymorphism of the endotoxin receptor (CD14 C-159T) was shown to be associated with atherosclerotic diseases such as myocardial infarction. This study was conducted to determine whether this polymorphism is associated with decreased kidney function. Methods. A total of 281 male and 522 female health check-up examinees, aged 39-88 years, were genotyped for CD14 C-159T. The glomerular filtration rate (GFR) was estimated by the Modification of Diet in Renal Disease (MDRD) Study equation. Estimated GFR (eGFR) and the proportion of subjects with mildly decreased eGFR (eGFR under 90 mL/min/ 1.73 m 2 ) were compared among the genotypes. Results. Subjects carrying the T allele showed decreased age-and sex-adjusted eGFR compared with those with CC genotype (101±22 vs. 105±23 mL/min/1.73 m 2 ; mean±SD, p=0.012). The proportion of subjects with mildly decreased eGFR was higher in T allele carriers (34.2% for TT+CT and 26.3% for CC genotype, p=0.041), but not statistically significant when adjusted for age and sex (odds ratio [OR] 1.41, 95% CI 0.97-2.05, p=0.076). In subjects under 65 years, T allele carriers had a significantly increased risk for mildly decreased eGFR (27.1% for TT+CT and 18.0% for CC; age-and sex-adjusted OR 1.82, 95% CI 1.06-3.12, p=0.030). Conclusion. CD14-159T allele was associated with decreased eGFR compared with CC genotype, and with a higher prevalence of mildly decreased eGFR in younger subjects under 65.

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CD14 C(−260)T gene polymorphism, circulating soluble CD14 levels and arteriosclerosis

Cited by 27 publications

References 34 publications

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

Association between Decreased Kidney Function and Endotoxin ReceptorCD14C-159T Polymorphism among Japanese Health Check-up Examinees

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