1994
DOI: 10.1016/1074-7613(94)90093-0
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CD14 Is a pattern recognition receptor

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Cited by 651 publications
(477 citation statements)
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“…6B), and the increased production was strongly inhibited by Tm-Gp. These cells have also been shown to express membrane CD14 [35]. Doublestranded viral RNA and bacterial CpG DNA were recently demonstrated to induce cell activation through TLR3 and TLR9, respectively [36,37].…”
Section: Inhibitory Effect Of Tm-gp On Cell Activation Induced By Varmentioning
confidence: 99%
“…6B), and the increased production was strongly inhibited by Tm-Gp. These cells have also been shown to express membrane CD14 [35]. Doublestranded viral RNA and bacterial CpG DNA were recently demonstrated to induce cell activation through TLR3 and TLR9, respectively [36,37].…”
Section: Inhibitory Effect Of Tm-gp On Cell Activation Induced By Varmentioning
confidence: 99%
“…Although the exact mechanisms of immune activation in pneumococcal meningitis are unknown, recent in vitro experiments provide a clue. The first step in immune activation is thought to be the binding of the pathogen associated molecular pattern (6) peptidoglycan and/or lipoteichoic acid to the pattern recognition receptor membrane CD14 (mCD14) (7)(8)(9). However, mCD14 by itself cannot transmit the activating signal into the cell due to the lack of a transmembrane domain connecting the extracellular domain to the cytoplasm (10).…”
Section: B Acterial Meningitis Caused By Streptococcus Pneumoniaementioning
confidence: 99%
“…To date, several studies have confirmed interactions of CD14 with a variety of microbial ligands such as lipopolysaccaride (LPS) from gram-negative bacteria, lipoteichoic acid (LTA) and peptidoglycan (PGN) from gram-positive bacteria, lipoproteins, lipoarabinomannan, polymannuronic acids and even with synthetic molecules [1,[5][6][7][8][9]. The ability of CD14 to interact with such structurally diverse endotoxins has led to the hypothesis that CD14 functions as a pattern recognition receptor by recognizing and binding to different pathogen-associated molecular patterns [7].…”
mentioning
confidence: 99%
“…The ability of CD14 to interact with such structurally diverse endotoxins has led to the hypothesis that CD14 functions as a pattern recognition receptor by recognizing and binding to different pathogen-associated molecular patterns [7]. It is believed that this pattern recognition may be important for high selectivity of CD14-mediated cellular activation and distinctiveness of the signaling pathway in response to specific ligands [10].…”
mentioning
confidence: 99%