CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice

Xu, Cheng; Liu, Xiaowei; Yu, Lei; Fang, Xiaoxin; Yao, Lei; Lau, HuiChong; Vyas, Punit; Pryke, Luke; Xu, Baohui; Tang, Lijiang; Jiang, Jianjun; Chen, Xiaofeng

doi:10.1016/j.intimp.2023.110526

International Immunopharmacology

2023

DOI: 10.1016/j.intimp.2023.110526

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CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice

Cheng Xu,

Xiaowei Liu,

Lei Yu

et al.

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2024

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Cited by 2 publications

References 40 publications

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FBXO22 is a potential therapeutic target for recurrent chondrosarcoma

Xin,

Chen,

Zhu

et al. 2024

Journal of Bone Oncology

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FBXO22 is a potential therapeutic target for recurrent chondrosarcoma

Xin,

Chen,

Zhu

et al. 2024

Journal of Bone Oncology

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Age-Disturbed Vascular Extracellular Matrix Links to Abdominal Aortic Aneurysms

Yu,

Wu,

et al. 2024

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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Abdominal aortic aneurysm (AAA) is a common but life-threatening vascular condition in men at an advanced age. However, the underlying mechanisms of age-increased incidence and mortality of AAA remain elusive. Here, we performed RNA sequencing (RNA-seq) of mouse aortas from males (young: 3-month, n = 4 vs old: 23-month, n = 4) and integrated with the data sets of human aortas (young: 20–39, n = 47 vs old: 60–79 years, n = 92) from GTEx project and the data set (GSE183464) for AAA to search for age-shifted aortic aneurysm genes, their relevant biological processes, and signaling pathways. Angiotensin II-induced AAA in mice was used to verify the critical findings. We found 1 001 genes transcriptionally changed with ages in both mouse and human. Most age-increased genes were enriched intracellularly and the relevant biological processes included mitochondrial function and translational controls, whereas the age-decreased genes were largely localized in extracellular regions and cell periphery and the involved biological processes were associated with extracellular matrix (ECM). Fifty-one were known genes for AAA and found dominantly in extracellular region. The common age-shifted vascular genes and known aortic aneurysm genes had shared functional influences on ECM organization, apoptosis, and angiogenesis. Aorta with angiotensin II-induced AAA exhibited similar phenotypic changes in ECM to that in old mice. Together, we present a conserved transcriptional signature for aortic aging and provide evidence that mitochondrial dysfunction and the imbalanced ribosomal homeostasis act likely as driven-forces for aortic aging and age-disturbed ECM is the substrate for developing AAA.

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CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice

Cited by 2 publications

References 40 publications

FBXO22 is a potential therapeutic target for recurrent chondrosarcoma

FBXO22 is a potential therapeutic target for recurrent chondrosarcoma

Age-Disturbed Vascular Extracellular Matrix Links to Abdominal Aortic Aneurysms

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