CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling

Qiao, Yong‐Kang; Tam, John Kit Chung; Tan, Sheryl S.L.; Tai, Yee Kit; Chin, Chin Yein; Stewart, Alastair G.; Ashman, Leonie K.; Sekiguchi, Kiyotoshi; Langenbach, Shenna; Stelmack, Gerald L.; Halayko, Andrew J.; Tran, Thai

doi:10.1016/j.jaci.2016.03.029

Cited by 16 publications

(20 citation statements)

References 37 publications

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“…The protein was subsequently reassigned as Cluster of Differentiation 151 (CD151) (Ashman, 2002). Whilst early reports identified CD151 as a surface protein, CD151 is also expressed intracellularly (Hwang et al, 2019), including cytoplasmic vesicles, endothelial cell junctions and perinuclear regions (Liu et al, 2007;Qiao et al, 2017).…”

Section: Cd151mentioning

confidence: 99%

“…Immunohistochemical staining showed that CD151 was found to be strongly positive in the lungs, specifically in airway smooth muscle (Qiao et al, 2017), epithelial layers, endothelial cells and blood vessels (Sincock et al, 1997). Given its abundance in lung tissue, the role of CD151 in normal and pathological processes in airways is especially relevant.…”

Section: Cd151mentioning

confidence: 99%

“…Expression of CD51 is clinically relevant to asthma as immunohistochemical analysis of human bronchial biopsy specimens for CD151 expression in airway smooth muscle bundles were highest in mild or moderate asthma subjects compared with non-asthmatic subjects (Qiao et al, 2017). In the same study, CD151 was implicated to play a role in airways hyperresponsiveness -loss-and gain-of-function studies showed that CD151 enhances G protein-coupled receptor (GPCR)induced calcium and protein kinase C signaling, which are key signaling pathways implicated in airway smooth muscle cell contraction.…”

Section: Hyperresponsiveness Mediator In Asthmamentioning

confidence: 99%

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CD151 in Respiratory Diseases

Wong

Tran

2020

Front. Cell Dev. Biol.

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The tetraspanin, Cluster of Differentiation 151 (CD151), is ubiquitously expressed in adult tissue, especially in the lungs where it has been implicated in lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF). CD151 interacts with lamininbinding integrins and growth factor receptors, and is reported in cancer-promoting processes such as tumor initiation, metastasis, and angiogenesis. In asthma, CD151 was shown to promote airways hyperresponsiveness through calcium signaling whereas in influenza, CD151 was shown to be a novel host factor for nuclear viral export signaling. Furthermore, CD151 was shown to be associated with increased disease severity and poorer survival outcome in asthma and lung cancer, respectively. In this review, we provide an update on the current understanding of CD151 with regards to its contribution to lung pathophysiology. We also summarize factors that have been shown to regulate CD151 expression and identify key areas that need to be taken into consideration for its utility as a screening or prognostic tool in disease management and/or as a therapeutic target for the treatment of lung diseases.

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Section: Cd151mentioning

confidence: 99%

Section: Cd151mentioning

confidence: 99%

Section: Hyperresponsiveness Mediator In Asthmamentioning

confidence: 99%

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CD151 in Respiratory Diseases

Wong

Tran

2020

Front. Cell Dev. Biol.

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“…This is largely because their short cytoplasmic tails are generally < 20 amino acids in length and lack canonical signaling motifs . However, several tetraspanins were recently shown to interact with intracellular signaling proteins such as phosphatidylinositol 3‐kinases (PI3K) and PKC . Tetraspanins can associate with a variety of transmembrane and cytosolic proteins to form tetraspanin‐enriched microdomains (TEMs), and influence cellular signaling pathways including cell proliferation, survival, adhesion, and motility .…”

mentioning

confidence: 99%

“…However, several tetraspanins were recently shown to interact with intracellular signaling proteins such as Abbreviations 2D, two-dimensional; CDK4, cyclin dependent kinase 4; Co-IP, Coimmunoprecipitation; DMSO, dimethyl sulphoxide; EGF, Epidermal growth factor; HCC, hepatocellular carcinoma; IP, immunoprecipitation; NATsDB, Natural Antisense Transcripts Database; p-Akt, phosphorylated Akt; PI3K, phosphatidylinositol 3-kinases; p-GSK3b, phosphorylated GSK3b; PKB, protein kinase B; qRT-PCR, quantitative real-time PCR; Rb, retinoblastoma; TEMs, tetraspanin-enriched microdomains; TSPAN31¸tetraspanin 31; 3 0 UTR 3 0 untranslated regions. phosphatidylinositol 3-kinases (PI3K) and PKC [9][10][11]. Tetraspanins can associate with a variety of transmembrane and cytosolic proteins to form tetraspaninenriched microdomains (TEMs), and influence cellular signaling pathways including cell proliferation, survival, adhesion, and motility [12,13].…”

mentioning

confidence: 99%

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells

Wang

Zhou

et al. 2017

FEBS Letters

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Tetraspanins are commonly believed to act as 'molecular facilitators', not directly involved in signal transduction. Tetraspanin 31 (TSPAN31), recently discovered to be linked to cancer, has not yet been studied in hepatocellular carcinoma (HCC). Here, we show that TSPAN31 is the natural antisense transcript of cyclin dependent kinase 4 (CDK4), and regulates the expression of CDK4 mRNA and protein. Target analysis indicates that miR-135b can directly regulate TSPAN31 expression. miR-135b-induced TSPAN31 silencing increases CDK4 protein levels. Interestingly, p53 negatively regulates TSPAN31 expression. siRNA-induced TSPAN31 knockdown reduces the expression of Akt signaling pathway components phosphorylated Akt, p-GSK3β and β-catenin, and restrains β-catenin migration to cell nucleus. TSPAN31 knockdown also significantly inhibits HCC cell invasion and migration. These findings thus point to TSPAN31 as a novel regulator in transduction of intracellular survival and apoptotic signals.

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Tetraspanins in the regulation of mast cell function

Orinska

Hagemann

Hálová

et al. 2020

Med Microbiol Immunol

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Mast cells (MCs) are long-living immune cells highly specialized in the storage and release of different biologically active compounds and are involved in the regulation of innate and adaptive immunity. MC degranulation and replacement of MC granules are accompanied by active membrane remodelling. Tetraspanins represent an evolutionary conserved family of transmembrane proteins. By interacting with lipids and other membrane and intracellular proteins, they are involved in organisation of membrane protein complexes and act as “molecular facilitators” connecting extracellular and cytoplasmic signaling elements. MCs express different tetraspanins and MC degranulation is accompanied by changes in membrane organisation. Therefore, tetraspanins are very likely involved in the regulation of MC exocytosis and membrane reorganisation after degranulation. Antiviral response and production of exosomes are further aspects of MC function characterized by dynamic changes of membrane organization. In this review, we pay a particular attention to tetraspanin gene expression in different human and murine MC populations, discuss tetraspanin involvement in regulation of key MC signaling complexes, and analyze the potential contribution of tetraspanins to MC antiviral response and exosome production. In-depth knowledge of tetraspanin-mediated molecular mechanisms involved in different aspects of the regulation of MC response will be beneficial for patients with allergies, characterized by overwhelming MC reactions.

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CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling

Cited by 16 publications

References 37 publications

CD151 in Respiratory Diseases

CD151 in Respiratory Diseases

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells

Tetraspanins in the regulation of mast cell function

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