Cd162

Barclay, A. Neil; Brown, Marion H.; Law, S.K. Alex; McKnight, Andrew J.; Tomlinson, Michael G.; Merwe, P. Anton van der

doi:10.1016/b978-012078185-0/50563-1

Cited by 1 publication

(1 citation statement)

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“…As well as ligand density and TCR affinity, the topology of protein-protein interaction at a membrane interface requires some thought. Both the TCR and its MHC ligands are 'short' molecules (about 7 nm) when compared with other more abundant cell surface molecules on T cells, such as the phosphatase CD45 (28-50 nm), the highly glycosylated surface protein CD43 (45 nm) and the integrin LFA-1 and its ligands, the intercellular adhesion molecules (ICAMs) [30][31][32]. This has raised the question of how the TCR and its MHC ligands ever bind to one another in the midst of this forest of giants.…”

Section: Immune Recognition and Responsementioning

confidence: 99%

Information transfer at the immunological synapse

2000

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Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact with their counter-receptors on the antigen-presenting cell to facilitate and complement the T-cell receptor-antigen recognition event. Recent studies have revealed that these various proteins show an unexpected degree of spatial organization in the zone of cell-cell contact. This region of membrane approximation is now referred to as the "immunological synapse" because of its functional analogy to the site of intercellular information transfer between neurons. Here, we review the evidence for signaling-dependent control of the dynamic changes in protein distribution that gives rise to the synapse and try to relate the emerging spatio-temporal information on synapse formation to T-cell biology.

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Section: Immune Recognition and Responsementioning

confidence: 99%