CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis

Huang, Ai Fang; Chen, Luyang; Huang, Shih Ming; Kao, Chu Lien; Lai, Hung Cheng; Chan, James Yi Hsin

doi:10.1186/1476-4598-12-115

Cited by 31 publications

(41 citation statements)

References 47 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In lung cancer, the positive associations were significantly existed between CD164 expression and tumor size, tumor cell grading, and lymph node involvement 14. Besides, a high abundance of CD164 protein was significantly correlated with high‐grade of ovarian tumors 15. In our study, the results of immunohistochemistry from 115 patients showed that high expression of CD164 was associated with clinical‐pathological characters such as distant metastasis and vascular invasion.…”

Section: Discussionsupporting

confidence: 54%

“…As CD164 acted as a CXCR4‐associated sialomucin, the relationship between CD164 and CXCR4 has been researched in many different cancers 15, 23. In our study, we used the immunohistochemistry to observe the association between the expression of CD164 and CXCR4 in tumor tissues by uninterrupted slicing.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have revealed that CD164 was involved in tumor progression via the regulation of cell proliferation and apoptosis in several cancers 13, 14, 15, 23, 32. In addition, CD164 was implicated in regulating the migration and invasion of lung cancer and medulloblastoma cells 17, 18.…”

Section: Discussionmentioning

confidence: 98%

“…In human cancers, CD164 was reported played roles in many different cancers. For instance, CD164 has been reported for the maintenance and progression of human tumors, such as human glioma,13 lung cancer,14 ovarian cancer,15 and prostate cancer 16. Besides, some microRNAs such as miR‐124 and miR‐219 were found that could suppress the proliferation, migration, and invasion of tumor cells by targeting CD164 17, 18.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

CD164 promotes tumor progression and predicts the poor prognosis of bladder cancer

Zhang

Li³

et al. 2018

Cancer Medicine

View full text Add to dashboard Cite

CD164 was found to play a role in many malignant diseases. But the roles of CD164 in human bladder cancer have not yet been studied. The object of our study was to investigate the functions of CD164 in urothelial bladder carcinoma. The immunohistochemistry (IHC) was performed to evaluate the associations between the expression level of CD164 and clinical‐pathological features of patients, and IHC was used to analyze the relationship between CD164 and CXCR4 in tumor tissues. Real‐time qPCR and Western blot were used to measure the expression of relevant genes. The roles of CD164 in tumor cells and tissues were investigated by in vitro and in vivo experiments. The results of immunohistochemistry found that CD164 was associated with clinical and pathological features of patients. High level of CD164 was related to the distant metastasis and vascular invasion of bladder cancer patients. In vitro, by silencing of CD164, the proliferation, migration, and invasion of tumor cells were inhibited significantly by regulating related proteins such as Ki67, proliferating cell nuclear antigen, matrix metalloproteinases‐2, and matrix metalloproteinases‐9. In vivo, knocking‐down of CD164 could reduce the growth and metastasis of tumors in mice. In addition, a co‐expression was found between CD164 and CXCR4 in tumor tissues. In conclusion, our study demonstrated that CD164 was associated with the poor clinical outcomes of BC patients. Silencing of CD164 could inhibit the progression of tumors in vivo and in vitro, which may become an effective target in the treatment of bladder cancer.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

CD164 promotes tumor progression and predicts the poor prognosis of bladder cancer

Zhang

Li³

et al. 2018

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…In prostate cancer, CD164 was found to promote metastasis through the chemokine receptor type 4 (CXCR4) / stromal cell-derived factor-1 (SDF-1) interaction (Havens et al, 2006). A recent study showed that CD164 promoted tumourigenicity through the CXCR4/SDF-1 α axis in an in vivo ovarian cancer model (Huang et al, 2013).…”

mentioning

confidence: 99%

Characterisation of glioblastoma subtypes: implications for therapy resistance

Cato¹

View full text Add to dashboard Cite

Glioblastoma is the most common malignant brain tumour in adults. Categorised by The World Health Organization as a grade IV glioma, it is the most aggressive, invasive form of glioma with a median survival time of 14.6 months. The incidence in the United States is approximately is two to three per 100,000. Glioblastoma is about 40% more common in males than in females and the average age at diagnosis is 64 years. Despite aggressive medical intervention including surgical resection followed by radiotherapy and chemotherapy, treatment increases survival by a median of only 2.5 months. Tumour recurrence occurs in the brain, frequently adjacent to the site of the original tumour. New therapies are needed to combat metastatic disease and tumour regeneration after therapy.

show abstract