CD19<sup>+</sup>CD5<sup>+</sup> B-cell expansion and risk of pre-eclampsia

El-Edel, Rawhia H; Bassuoni, Maha A El; Radwan, Wafaa M; Masoud, Alaa; El-Deeb, Sara Mahmoud

doi:10.4103/1110-2098.192433

Cited by 5 publications

(3 citation statements)

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“…However, there are studies emerging regarding their association with hypertensive disorders in pregnancy. The number of peripheral blood B1a cells in women with preeclampsia is significantly increased compared to normal pregnant women (60), however no difference in their number between severe and mild preeclampsia has been observed (130). In addition to the well-established Th1/Th2/Th17-Treg paradigm of the pathogenesis of preeclampsia [as reviewed in (131)], the role of B1 cells is likely linked to stimulation of CD4 + T cells and their differentiation into Th17 effector cells (132).…”

Section: The Role Of Innate B1 Cells In Preeclampsiamentioning

confidence: 99%

Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

et al. 2020

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Section: The Role Of Innate B1 Cells In Preeclampsiamentioning

confidence: 99%

Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

et al. 2020

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“…It is also demonstrated that human amniotic fluid stromal cells induce down-regulation of the proportion of B1 cells [150], resulting in the reduction of the B cell subset mainly involved in the production of autoantibodies in PE [151][152][153]. Many studies have shown that perinatal cell and their CM are able to block antibody-secreting cells CD19 + CD27 + CD38 + and the differentiation of B cells into CD138 + plasma cells, resulting in the reduction of secreted immunoglobulin [11,147,150].…”

Section: Impact Of Cytotrophoblast Cells and Placenta-derived Exosome...mentioning

confidence: 99%

Immunosuppression and Immunomodulation

2023

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Meet the editors Dr. Rajeev K. Tyagi obtained a Ph.D. from the Biomedical Parasitology Unit, Institute Pasteur, France, in 2011 with a study on malaria immunology/parasitology. He developed a long-lasting, stable, and straightforward laboratory animal model to study the biology and immunology of infectious diseases and more. Dr. Tyagi continued to work on parasite immunology and mouse-human chimeras development at the University of South Florida, USA, and explored the asexual blood and liver stage infection of P. falciparum. Dr. Tyagi discovered a novel dendritic-like cell population called "pathogen differentiated dendritic cells (PDDCs)" when incubated with P. gingivalis and tracking of monocyte-derived dendritic cells (MoDcs) in a reconstituted immunodeficient NOD.Prkdc scid Il2rg -/-(NSG) mice at Augusta University, USA. Dr. Tyagi explored IL-23R in the modulation of the functioning of regulatory T cells and its role in the pathogenesis of colitis in an experimental humanized mouse at Vanderbilt University Medical Centre (VUMC), USA. Currently, Dr. Tyagi leads a research group at

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“…A few indications suggest a role for B-1a cells in the production of these autoantibodies. In fact, the frequency of CD19 + CD5 + B-1a cells was reported to significantly decrease in the peripheral blood of healthy pregnant women during the third trimester [ 81 , 82 ], while it remained high in patients with PE [ 82 , 83 ]. Of note, the frequency of the total CD19 + B cells remains relatively constant in normal and in PE pregnancies [ 82 ].…”

Section: Focus On B Cellsmentioning

confidence: 99%

The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

Magatti

Masserdotti

Cargnoni

et al. 2021

IJMS

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The pathophysiology of preeclampsia (PE) is poorly understood; however, there is a large body of evidence that suggests a role of immune cells in the development of PE. Amongst these, B cells are a dominant element in the pathogenesis of PE, and they have been shown to play an important role in various immune-mediated diseases, both as pro-inflammatory and regulatory cells. Perinatal cells are defined as cells from birth-associated tissues isolated from term placentas and fetal annexes and more specifically from the amniotic membrane, chorionic membrane, chorionic villi, umbilical cord (including Wharton’s jelly), the basal plate, and the amniotic fluid. They have drawn particular attention in recent years due to their ability to modulate several aspects of immunity, making them promising candidates for the prevention and treatment of various immune-mediated diseases. In this review we describe main findings regarding the multifaceted in vitro and in vivo immunomodulatory properties of perinatal cells, with a focus on B lymphocytes. Indeed, we discuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation. Therefore, the findings discussed herein unveil the possibility to modulate B cell activation and function by exploiting perinatal immunomodulatory properties, thus possibly representing a novel therapeutic strategy in PE.

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CD19⁺CD5⁺ B-cell expansion and risk of pre-eclampsia

Cited by 5 publications

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Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

Immunosuppression and Immunomodulation

The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

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CD19+CD5+ B-cell expansion and risk of pre-eclampsia

Cited by 5 publications

References 0 publications

Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

Immunosuppression and Immunomodulation

The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

Contact Info

Product

Resources

About

CD19⁺CD5⁺ B-cell expansion and risk of pre-eclampsia