CD1dhiCD5+ B Cells Expanded by GM-CSF In Vivo Suppress Experimental Autoimmune Myasthenia Gravis

Sheng, Jinhua; Quan, Songhua; Soliven, Betty

doi:10.4049/jimmunol.1303397

Cited by 44 publications

(38 citation statements)

References 75 publications

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“…IL-10 derived from CD1dhighCD5+ B cells was also proven to regulate experimental autoimmune myasthenia gravis. Adoptive transfer of IL-10 competent CD1highCD5+ B cells led to higher frequency of Treg and B10 cells, and low levels of proinflammatory cytokines and autoantibody production [19]. In addition to the above discussed in vitro and animal model studies, many researchers have shown that Breg cells including their ability to produce IL10 were altered in many immune/autoimmune-mediated diseases such as RA, psoriasis, and systemic sclerosis.…”

Section: Cd19+cd38highil-10highmentioning

confidence: 97%

FoxP3 Expression in Macrophages, Cancer, and B Cells—Is It Real?

Vadasz

Toubi

2016

Clinic Rev Allerg Immunol

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During the last decade, B regulatory cells are appreciated to have a central role in preventing autoimmunity and maintaining self-tolerance. They are characterized by expressing different phenotypic markers and the production of either IL-10 or TGF-β or both. The recent recognition of Fas ligand expressing B regulatory cells as "killer" cells established their role in maintaining viral persistence by preventing effective antiviral immune responses. The forkhead lineage-transcription factor (FoxP3) was considered for many years to be a highly specific intracellular regulatory marker of CD4+CD25+ T regulatory cells. The possibility of FoxP3 being expressed in B regulatory cells was suggested in many studies. Though controversial, FoxP3 expression was also reported in macrophages and cancer cells. Aiming to avoid artifact staining, many researchers required the usage of FoxP3 messenger RNA (mRNA) and PCR in order to prove a true expression of FoxP3 in these different cells. In addition, most studies' report on that FoxP3 expression in all abovementioned cells is related to their status of activation since naïve (non-activated cells) were found poorly FoxP3 expressing. In this review, we present the existing data on FoxP3 expression in non-T-regulatory cells, but we suggest that further studies are needed to better establish this concept.

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Section: Cd19+cd38highil-10highmentioning

confidence: 97%

FoxP3 Expression in Macrophages, Cancer, and B Cells—Is It Real?

Vadasz

Toubi

2016

Clinic Rev Allerg Immunol

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“…The implications of these data are not clear; it is possible that GM-CSF can modulate immune responses by regulating autoantibody production. In a recent study it was found that GM-CSF can expand IL-10 producing subset of CD1d high CD5 + B-cells (also called B10 cells) (146). A fusion protein comprising of GM-CSF and IL-15 has previously been shown to induce B10 cells in vitro (147).…”

Section: Introductionmentioning

confidence: 99%

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity

et al. 2015

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GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells. Multiple studies have demonstrated that GM-CSF is also an immune-modulatory cytokine, capable of affecting not only the phenotype of myeloid lineage cells, but also T-cell activation through various myeloid intermediaries. This property has been implicated in the sustenance of several autoimmune diseases like arthritis and multiple sclerosis. In contrast, several studies using animal models have shown that GM-CSF is also capable of suppressing many autoimmune diseases like Crohn's disease, Type-1 diabetes, Myasthenia gravis and experimental autoimmune thyroiditis. Knockout mouse studies have suggested that the role of GM-CSF in maintaining granulocyte and macrophage populations in the physiological steady state is largely redundant. Instead, its immune-modulatory role plays a significant role in the development or resolution of autoimmune diseases. This is mediated either through the differentiation of precursor cells into specialized non-steady state granulocytes, macrophages and dendritic cells, or through the modulation of the phenotype of mature myeloid cells. Thus, outside of myelopoiesis, GM-CSF has a profound role in regulating the immune response and maintaining immunological tolerance.

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“…In an EAE model, the adoptive transfer of B10 cells normalized the disease, but the transfer of IL-10 −/− B10 or other B-cell subsets did not. 80 Unsurprisingly, the adoptive transfer of B10 cells inhibited the disease even after disease onset. 80 Unsurprisingly, the adoptive transfer of B10 cells inhibited the disease even after disease onset.…”

Section: Cd19 + Cd1d Hi Cd5 + (B10) Bregsmentioning

confidence: 99%

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Alhabbab

Nova‐Lamperti

Aravena

et al. 2019

Immunological Reviews

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The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of “inhibitory” antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody‐independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.

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CD1dhiCD5+ B Cells Expanded by GM-CSF In Vivo Suppress Experimental Autoimmune Myasthenia Gravis

Cited by 44 publications

References 75 publications

FoxP3 Expression in Macrophages, Cancer, and B Cells—Is It Real?

FoxP3 Expression in Macrophages, Cancer, and B Cells—Is It Real?

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

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