CD2+ hairy cell leukemia

CD5‐negative chronic lymphocytic leukemia: Does this entity really exist?

“…Second, at the outset, it is worth emphasizing that we have no concerns about the existence of immunophenotypic aberrancies in hematological diseases of the most diverse lineages. To take just a few examples, we have previously shown that some cases of Sézary syndrome, a T-cell disease, may express antigens of the natural-killer lineage (CD56, CD57, and granzyme B) (Matos et al, 2018) and that very rare cases of hairy cell leukemia, a B-cell disease, may express the CD2 antigen (Matos, 2023). Hence, we presume the existence of what have been imprecisely called "atypical" phenotypes of CLL, such as bright expression of CD20 or CD79b or even the unusual presence of T-cell antigens, such as CD8 (Matos, 2019).…”