CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases

Li, Jing; Song, Zhao; Wang, Jingxuan; Chen, Jingyu; Wen, Wen; Zhang, Qingyuan

doi:10.1007/s13277-015-4205-5

Cited by 26 publications

(39 citation statements)

References 63 publications

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“…[15][16][17][18] Rare cases with Napsin A expression have also been described. The cells are typically CD30 nonreactive (negative); although, focal areas of positivity for CD30, CD79a, and AE1/3 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Sakr

Cruise

Chahal

et al. 2016

Diagnostic Cytopathology

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Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a rare distinct type of non-Hodgkin's lymphoma that arises in association with alterations of the ALK gene. This distinct disease entity is typically associated with an aggressive clinical course and appears in light microscopic preparations as a monomorphic population of large, immunoblast-like cells. In this report, we describe a case of ALK+ LBCL diagnosed by transgastric endoscopic ultrasound-guided fine needle aspiration (EUS FNA) of splenic hilar lymph nodes. Modified Giemsa stained direct smears from the FNA sample demonstrated large lesional cells with foamy cytoplasm and macronucleoli admixed with small lymphocytes in tigroid backgrounds, mimicking the cytologic appearance of seminoma. Ancillary immunohistochemical studies subsequently confirmed the diagnosis of ALK+ LBCL with the lesional cells being immunoreactive for CD138, VS38c, MUM1, ALK1, and lambda light chain. The cohesiveness of the cells, the cellular morphology, and the tigroid backgrounds were all pitfalls for accurate diagnosis of this rare specific type of lymphoid malignancy by cytology. To our knowledge this is the first case report detailing the diagnosis of ALK+ LBCL by EUS FNA and the first report describing a glycogen-rich tigroid background in direct FNA smears. Establishing a refined diagnosis in cases of this rare form of LBCL is necessary, as therapies targeting ALK may be of value in clinical management. Diagn. Cytopathol. 2017;45:148-155. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Sakr

Cruise

Chahal

et al. 2016

Diagnostic Cytopathology

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“…CD30 was found to be variably positive in 81% of PTLD/DLBCL [7] and in about 14% of immunocompetent patients with DLBCL [8]. CD30 expression is reported to be associated with a favorable outcome in PTLD/DLBCL, regardless of EBV status [7].…”

Section: Discussionmentioning

confidence: 98%

Diffuse Large B-Cell Lymphoma Trans-differentiating into CD30 Positive Anaplastic Large Cell-like Lymphoma

Bains¹

2017

Ann Hematol Oncol

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Post-Transplant Lymphoproliferative Disorders (PTLD) is mostly of B-cell origin. "Composite" PTLD with diffuse large B-cell lymphoma (DLBCL) and T/ anaplastic large cell lymphoma component are extremely rare. We report a case of PTLD after heart transplant with two distinct components. The patient was initially diagnosed with monomorphic PTLD/DLBCL, EBV negative involving the intestinal wall, occurring nine years after heart transplantation. Sixteen years post-transplant, the lymphoma recurred involving the intestine and showed two distinct components: DLBCL and anaplastic large cell lymphoma with strong homogeneous expression of CD45 and CD30 while lacking B-and T-cell lineage markers mimicking Anaplastic Large Cell Lymphoma (ALCL), ALK negative with a null-cell phenotype and TIA-1 expression. At this time, diffuse lymphadenopathy was also present and a jugular lymph node biopsy prior to the intestinal resection, purely demonstrated only the anaplastic large lymphoma cells with a null-cell phenotype leading to the diagnosis of ALCL, ALK negative. However, molecular studies performed on the anaplastic large cell component identified strongly positive clonal IgH gene rearrangement, identical to the prior lymphoma. Extensive sampling from the intestinal resection specimen identified a transitioning phase between two morphologically and immunohistochemically separate components. This is a unique case of PTLD which demonstrates an immunophenotypic lineage plasticity of the neoplastic cells over an extended post-transplant period.

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“…This may be particularly important for cytopathologists given that immunohistochemical studies often have a faster turnaround time than [38][39][40][41] Rare cases with Napsin A expression have also been described. Therefore, immunohistochemical studies may be important to perform in these cases in addition to in situ hybridization testing.…”

Section: R Esu L Tsmentioning

confidence: 99%

Cytologic perspectives on neoteric B‐cell lymphoproliferative disorders

Sturgis

Sakr

Pantanowitz

2017

Diagnostic Cytopathology

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The 2008 World Health Organization (WHO) classification of hematopoietic and lymphoid tissues has been recently revised, and publication of the updated 2016 version is expected soon. Given that cytopathologists are often involved in the diagnosis of primary, recurrent, and transformed lymphoproliferative disorders, knowledge of updates to the WHO lymphoma classification, including terminology, pathogenesis, ancillary techniques, and targeted therapies is necessary. Herein, we reference the last decade of cytology specific literature for seven newer B-cell disorders and provide illustrative examples of each entity from our files.

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CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases

Cited by 26 publications

References 63 publications

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Anaplastic lymphoma kinase positive large B‐cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma

Diffuse Large B-Cell Lymphoma Trans-differentiating into CD30 Positive Anaplastic Large Cell-like Lymphoma

Cytologic perspectives on neoteric B‐cell lymphoproliferative disorders

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